Navigation Links
Mixed HIV Coreceptor Use Associated With Lower CD4 Count

Patients who have been heavily treated with antiretroviral drugs have a high proportion of viral strains that can use two types of chemokine receptors to infect cells, according// to a study published in the February 15th edition of Clinical Infectious Diseases.

The researchers, led by Timothy J Wilkin of Weill-Cornell Medical College, New York, also found that people with HIV that can use both receptors (known as dual-tropic virus) had lower CD4 cell counts than people with virus that uses the CXCR4 receptor (the viral type associated with a higher risk of disease progression). The findings lend further weight to the need to test for coreceptor usage in patients who may be eligible to take the new chemokine receptor inhibitor, maraviroc, now in development.

HIV infects cells by first binding to the CD4 receptor and then one of two coreceptors, the chemokine receptors CCR5 and CXCR4. Usually, these receptors are the targets for substances that activate white blood cells in response to inflammation. HIV that can use CCR5 tends to predominate early in infection while the presence of virus that can use CXCR4, known as syncitium-inducing virus, has been linked with an increased risk of progression to AIDS and death.

Currently, new potential antiretroviral treatments are in clinical trials to block chemokine receptors in the hope of preventing HIV entry into cells. The study reported here was part of a trial of the CCR5 inhibitor vicriviroc in heavily treatment-experienced patients.

The investigators write, “With their novel mechanism of action, CCR5 inhibitors should have antiretroviral activity for HIV-1–infected patients with uncontrolled viremia and few other treatment options (e.g. patients with multidrug-resistant virus)”. However, they note, these compounds are most likely to be effective if the individual is infected with CCR5-using virus alone. So the team tested the viral strains from all participants screened
'"/>




Page: 1 2 3 4

Related medicine news :

1. Mixed Opinion Regarding Common Medical And Engineering Entrance Test
2. New Medicare Plan - Mixed Reaction among Pharmacists.
3. Mixed Orientation Marriages Calls for Deeper Understanding
4. Mixed response Evoked Among The Tribal Elders For The Call On Smoking Ban
5. Mixed Wards Cause Trauma in Female Patients in Britain
6. Stem Cell Banking Evokes Mixed Response
7. Generic Biologics – U.S Panel Hearing Draws Mixed Response
8. Mixed Sex Wards Still Continue For Psychiatric Patients
9. Moderate Use of Analgesics - Not Associated With Kidney Dysfunction
10. Bayer Voluntarily Withdraws BAYCOL - A Drug Associated With 50 Deaths
11. Associated therapy for multiple myeloma
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mixed HIV Coreceptor Use Associated With Lower Count

(Date:8/4/2015)... ... August 04, 2015 , ... Increasingly, patients are ... calling a physician. In an effort to share more and better information with ... Pennsylvania to publicly share patient satisfaction ratings and comments about its doctors and ...
(Date:8/4/2015)... Louis, Missouri (PRWEB) , ... August 04, 2015 ... ... Texting (IAT) solutions, today announced that Bruce McCalley joins its executive leadership team ... track record of sales success at technology companies and expanding global markets with ...
(Date:8/4/2015)... ... August 04, 2015 , ... Montclair State University and Atlantic Health System ... its kind in New Jersey, which starting this Fall will help prepare those entering ... partnered with Atlantic Health System, one of the largest health care organizations in New ...
(Date:8/4/2015)... York (PRWEB) , ... August 04, 2015 , ... It’s ... begin to describe the customer experience inside Naimie’s Beauty Center in LA. Now MENAJI ... learn how to look better. , Naimie’s Beauty Center has been a favorite of ...
(Date:8/4/2015)... , ... August 04, 2015 ... ... HealthCenter personal health record (PHR) product has achieved Office of the National ... EHR Certification from Drummond Group. HealthCenter delivers the highest quality personal health ...
Breaking Medicine News(10 mins):Health News:UPMC 1st in Pa. to Share Provider Ratings 2Health News:UPMC 1st in Pa. to Share Provider Ratings 3Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 2Health News:SanusEO Hires Healthcare Technology Executive Bruce McCalley As Senior Vice President of Sales & Marketing 3Health News:Atlantic Health System & Montclair State University Launch Graduate Program in Arts & Health 2Health News:Atlantic Health System & Montclair State University Launch Graduate Program in Arts & Health 3Health News:MENAJI Shines in Make-Up Mecca for Stars 2Health News:MedicaSoft's HealthCenter Earns ONC-HIT Certification from Drummond Group 2Health News:MedicaSoft's HealthCenter Earns ONC-HIT Certification from Drummond Group 3
... women in the Nurses' Health Study has shown that Type ... the most common form of glaucoma//, accounting for about 60 ... the July issue of the journal Ophthalmology. ,Researchers ... ,Hospital, Harvard School of Public Health and Harvard Medical School ...
... used to reduce the levels of LDL cholesterol in ... cause serious muscle// damage. ,Health Canada has ... Pravachol, Zocor, Crestor and Mevacor to include warnings and ... safety information sheets. ,Statin drug users usually ...
... including MRSA, has found its way to the markets of ... one of the few new antibiotics to come on to ... organisms have undergone mutations that enabled them to develop resistance ... MRSA, in hospitals. ,The new drug Tygacil is ...
... degeneration (AMD) is twice as common in elderly smokers as ... the elderly who ate fish at least twice weekly are ... eat fish less than once a week. ... who work at the Massachusetts Eye and Ear Infirmary, which ...
... significantly reduce the load of HIV in Africa.// ... Journal PLoS Medicine, was done on a research, published ... in heterosexual men by about 60%. Now an international ... the research, across Africa to predict the potential impact. ...
... detailing the rampant sexual abuse in NHS mental units is ... in UK eight months ago. //The report says that more ... in the last 24 months. ,The Times newspaper ... which three resulted in pregnancy. Health officials maintain that the ...
Cached Medicine News:Health News:Type 2 Diabetes Increases the Risk of Glaucoma in Women 2Health News:New Drugs To Combat Mutant Bugs 2Health News:Save your Vision with Fish Oil and Quitting Smoking 2Health News:Practise Of Male Circumcision In Africa May Reduce HIV Risks 2
(Date:8/4/2015)... 2015  The Pittsburgh Life Sciences Greenhouse (PLSG), the ... that one of its portfolio companies, Medrobotics Corporation, has ... Robotic System in the U.S.  ... Medrobotics," said John W. Manzetti , president and ... way since spinning out of The Robotics Institute at ...
(Date:8/4/2015)... , Aug. 4, 2015  Intec Pharma Ltd. (the ... company focused on developing drugs based on its proprietary ... its initial public offering in the United ... at a price to the public of $6.00 per ... the ordinary shares are being offered by the Company.  ...
(Date:8/4/2015)... 4, 2015 P&S Market ... overview, trends, DRO analysis, market segmentation, market size ... and top competitor profiles in: Global ... Development and Demand Forecast to 2020  ... Explore full reports with detailed TOC on Global ...
Breaking Medicine Technology:Pittsburgh Life Sciences Greenhouse Portfolio Client Medrobotics Receives FDA Market Clearance 2Pittsburgh Life Sciences Greenhouse Portfolio Client Medrobotics Receives FDA Market Clearance 3Intec Pharma Ltd. Announces Pricing of U.S. Initial Public Offering 2Intec Pharma Ltd. Announces Pricing of U.S. Initial Public Offering 3Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 2Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 3Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 4Global Drug of Abuse (DOA) Testing Market (Size of $2.9 Billion in 2014) to Witness 5% CAGR During 2015 - 2020 5
... Calif., Oct. 11 Threshold,Pharmaceuticals, Inc. (Nasdaq: THLD ... analysis, it would stop enrollment in a Phase 2 ... patients with,recurrent, sensitive small cell lung cancer. The ... there would be,an adequate response rate to justify complete ...
... KineMed Inc., a,pathway-based drug discovery and development company, ... an investigational agent,to regenerate nerve cells in the ... and mood. The agent, part of a partnered ... behavioral test in a,preclinical model. The findings were ...
Cached Medicine Technology:Threshold Pharmaceuticals to Stop Enrollment in Clinical Trial 2Threshold Pharmaceuticals to Stop Enrollment in Clinical Trial 3KineMed Presents Preclinical Data for Investigational Agent Demonstrating Neurogenesis and Confirming Improvements in Behavioral Model 2KineMed Presents Preclinical Data for Investigational Agent Demonstrating Neurogenesis and Confirming Improvements in Behavioral Model 3
Invacare 5 Oxygen Concentrator, 230 VAC - Intl....
... peptic ulcers are caused by H. pylori ... while the patient is still present with ... of waived or non-waived laboratories.,The Right Choice ... rapid H. pylori test available; helps to ...
... CHECK 02 PLUS CONCENTRATOR ANALYZER Now there ... the operating parameters necessary for performing concentrator ... ™, an efficient and cost-effective analyzer designed ... concentration (%), flow rate (L-min), and patient ...
... Exclusively for the Japanese market:, ... advanced, low-sound level, low-power-consumption, high-performance oxygen ... settings., ,Offered in an attractive, ... was specifically designed to meet the ...
Medicine Products: