Navigation Links
'Mix and match' of proteins may have a significant role in immunity

Proteins appear to transform more often than biologists once thought. Cutting and rearrangement of the components of these molecules into new structures is carried out by// the human cells.

The immune system of the body may be enhanced by this mechanism. This method could also help researchers understand better how the immune system recognizes the infected cells that need to be attacked.

Depending on the specific type of protein required, an RNA template, produced by the DNA, is cut and rearranged. It has been assumed by biologists for a long period that rearrangement occurs only at the RNA level. However, in 2004, scientists found that this was not the case in proteins found in skin-cancer cells. These molecules, at protein level, seem to undergo rearrangement. This type of ‘Protein Surgery’ has been reported in plants and single-celled organisms.

Recently, it was reported by Edus Warren of the Fred Hutchinson Cancer Research Center in Seattle, Washington, and his colleagues that cutting and modification took place at protein level in some normal cells. They have reported in this week’s Science that proteins can undergo chopping and alteration to produce a variety of structures from the original protein.

Peptides, a group of short proteins found on cell surface, were studied by the team. T-cells use these peptides to identify a foreign body. Degradation of proteins by cell machinery called the proteasome, which digests the proteins and cuts it into pieces, leads to the formation of peptides.

"The proteasome can splice peptides together," says Warren. “Every once in a while, new peptide bonds will be created, not just destroyed. It isn't clear why this happens, or what the newly spliced peptides do. But as the molecules end up on the cell's surface, they are probably involved in the cell's "immunologic identity",” he says.

According to a recent study, peptides, made in this manner found on cells fr om a leukaemia patient who had received a bone-marrow transplant, activated an immune response from the Tcells in the transplanted marrow.

Scientists contemplate that peptide splicing may enhance the immune system’s recognition of virus infected cells. Since viruses replicate inside the cell, they could produce new peptides on the cell surface, whose subsequent rearrangement may improve the chances of the immune system to recognize the invader.

Whether all cells use their proteasomes to rearrange all types of proteins, or whether the mechanism is specific to peptides used by the immune system, is still unclear. Warren believes that the mechanism will be found elsewhere. "There is no reason why cells could not have learned how to use this mechanism to their advantage. But I don't think that people have ever looked," he says.

'"/>




Related medicine news :

1. Special proteins to fight TB identified
2. Special proteins to fight TB identified
3. Obese children may have abnormalities of lipoproteins
4. The bitter proteins
5. Tattoos may significantly increase risk of hepatitis C infection
6. Just one cigarette could cause significant damage
7. Plants have ability to significantly lower LDL cholesterol through sterol pills
8. Link Between Vietnam Service And Prostate Cancer Is Statistically Insignificant
9. Stem cell transplant recipients face significant risk of second cancer
10. Stress reduces your immunity- startling but true!!!!!
11. Omega-3 fatty acids impair immunity
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/29/2016)... ... April 29, 2016 , ... Our bodies are bombarded daily by environmental and ... with these stressors is to adopt a more healthful diet, but too many people ... a certified Holistic Nutritionist and the creator of the Newport Beach Cleanse and 14-Day ...
(Date:4/29/2016)... ... 29, 2016 , ... The White House announced efforts yesterday ... information about their loan terms and accounts, and more protections for borrowers. The ... and private loans, has reached $1.3 trillion, with 43 million Americans holding student ...
(Date:4/29/2016)... ... ... Spine Team Texas, a comprehensive spine physician group specializing in the treatment of ... invited to be a featured speaker at the Texas Society of the American College ... , Dr. R. Scott McPherson, a physical medicine and rehabilitation specialist, will speak ...
(Date:4/29/2016)... ... April 29, 2016 , ... The ... (CCA), is pleased to announce the launch of the GFCP Scoop ... and more. The purpose of the GFCP Scoop site is to ...
(Date:4/29/2016)... ... 29, 2016 , ... Reltok Nasal Products proudly announces that Boston Medical Products, ... nose and throat specialty, has added the KOTLER NASAL AIRWAY™ to its diverse product ... a newly patented safety device secured by nasal surgeons onto the floor of the ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... , April 29, 2016  In the ... projected to shift from systems dependent on CRTs monitors ... types of modality CRT Medical monitors and will ... are a host of foreseeable benefits to this ... will existing modalities have to be replaced in ...
(Date:4/29/2016)... , April 29, 2016 ... H1 2016" market research report that provides an ... comparative analysis at various stages, therapeutics assessment by ... administration (RoA) and molecule type, along with latest ... also reviews key players involved in the therapeutic ...
(Date:4/29/2016)... New Jersey , April 29, 2016 /PRNewswire/ ... Software Suite for Life Sciences, Product Development Capabilities ... Global Life Science Customer Base . ... solutions provider, today announced the acquisition of Skura ... a global leader in adaptive sales enablement technology ...
Breaking Medicine Technology: