Navigation Links
Mitochondrial Protein Maintains Appetite During Fasting

Researchers at Yale School of Medicine have found that a thyroid hormone in the brain is linked to the “uncoupling” protein UCP2, which can maintain appetite during periods// of fasting so that the body is ready to eat when food is reintroduced.

Published in the January issue of Cell Metabolism, the study was conducted by observing the behavior of mice that fasted for 24 hours. The researchers, led by Sabrina Diano, associate professor in the Departments of Obstetrics, Gynecology & Reproductive Sciences and Neurobiology, found that during fasting there was an increase in UCP2 as well as an increase in the type 2-deiodinase enzyme that stimulates thyroid hormone production in the hypothalamus.

When the mitochondrial protein UCP2 was activated due to fasting, the number of mitochondria increased in the neurons, which increased excitability in the brain cells that are critical in initiating eating. The researchers also showed that “knock-out” mice that lacked UCP2 or type 2 deiodinase ate less after fasting.

“We found that a cellular mechanism that is similar to that involved in generating body heat is also present in the brain,” said Diano. “UCP2 appears to be an important player in regulating neuronal function associated with feeding. We would like to conduct further studies to learn whether this mechanism may indeed have thermogenic consequences in the brain and if so, whether selective cooling or heating of the hypothalamus could affect metabolism.”

Diano said the mitochondria in the brain appear to be important players in regulating neuronal function associated with feeding behavior and energy expenditure. Mitochondrial dysfunction in peripheral tissues such as liver and muscle has been shown to play a critical role in insulin resistance in diabetes. This study indicates that brain mitochondrial dysfunction may also play a critical role in the etiology of obesity and diabetes.

Source: Yale UniversityBR>SR M
'"/>




Related medicine news :

1. Researchers Have Linked Rett Syndrome to Mitochondrial Gene
2. MitoChip v2.0 – the new Mitochondrial DNA sequencing too
3. High -tech Mitochondrial DNA Sequencing Tool Updated
4. Lean Protein Could Be Key to Obesity Drugs
5. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
6. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
7. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
8. Protein in urine foresees heart disease
9. Levels Of Blood Proteins May Help Heart Disease Care
10. Protein signals need for heart surgery
11. Protein and fat improve memory
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their ... Eyeglasses . , Millions of individuals in the United States and Canada wear eyeglasses. ... way to both correct vision and make a fashion statement. Even celebrities use glasses ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/25/2016)... Austin, TX (PRWEB) , ... June 25, 2016 , ... ... Fellow of the American College of Mohs Surgery and to Dr. Russell Peckham for ... popular and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic ...
(Date:6/25/2016)... ... ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors in ... School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green Hospital ... at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train in ...
(Date:6/24/2016)... ... , ... A recent article published June 14 on E Online ... on to state that individuals are now more comfortable seeking to undergo not only ... calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 26, 2016 One of Australia,s ... formation of a new biotechnology company, Noxopharm Limited [ABN 50 608 ... IPO and to list on the ASX. Noxopharm is ... to enter a Phase 1 clinical study later this year. ... one of the biggest problems facing cancer patients - the ability ...
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... Antitrust Improvements Act of 1976, as amended ("HSR"), with ... ("Celator"; Nasdaq: CPXX ) expired effective June ... As previously announced on May 31, 2016, Jazz ... under which Jazz Pharmaceuticals has commenced a tender offer ...
(Date:6/26/2016)... June 27, 2016  VMS Rehab Systems, Inc. ( ... take whatever measures required to build a strong and ... is currently listed on the OTC Markets-pink current trading ... and CEO, "We are seeing an anomaly in market ... not only by the Company, but shareholders and market ...
Breaking Medicine Technology: