Navigation Links
Missing Molecule Has Important Role in a Developmental Brain Abnormality

A molecule that is part of a complex signaling network in the developing brain plays //a critical role in periventricular heterotopia (PVH), a congenital brain malformation, Yale School of Medicine researchers report in Neuron.

PVH often leads to a variety of neurological disorders such as epilepsy, mental retardation, and learning or memory deficits. It has many environmental and genetic causes, but is most commonly due to mutations in the gene Filamin-A. Pasko Rakic, professor and chair of neurobiology, director of the Kavli Institute for Neuroscience, and senior author of the study, said that up until now the molecular mechanisms that regulate Filamin-A in the brain are not well understood. This study shows that the molecule MEKK4 regulates Filamin-A and its loss contributes to PVH. “We show that MEKK4 deficiency leads to both a breakdown in the lining of the fetal ventricles and abnormally high levels of Filamin-A within the proliferative areas,” Rakic said. Using advanced molecular methods, the researchers showed that the loss of MEKK4 can result in an excess of Filamin-A, and inhibit neuronal migration. The grey matter of human cerebral cortex contains over two billion neurons, but none of them are produced in the cortex itself. Cortical neurons are born near the lining of the fluid-filled ventricles deep within the fetal brain and after their last division migrate to their increasingly distant final destination in the outer cortex. To do this, migrating neurons must climb along transient scaffold of radial glial fibers that span the developing cortex. “Upon reaching their final destination, neurons stop migrating and establish specific connections with other neurons,” Rakic said. “This is a dynamic and complex process that, in humans, occurs during gestation over many months and is regulated by numerous molecules, especially by those that control nuclear and cell body movement.” The Filamin-A protein binds and organizes the intrace llular contractile protein called actin, which is essential for neuronal migration. It was reported in this study that MEKK4 is important for maintaining the correct level of Filamin-A and the integrity of the ventricular surface lining, both of which contribute to the pathogenesis of PVH. Co-authors include Matt Sarkisian, Christopher Bartley, Hongbo Chi, Fumihiko Nakamura, Kazue Hashimoto-Torii, Masaaki Toril, and Richard Flavell, chair and professor of immunobiology.

Source-BioBioTechSRM
'"/>




Related medicine news :

1. Gene linked to Missing Eye condition in newborns
2. Missing Protein In Cancer Development
3. Missing teeth associated with blocked arteries
4. Diabetic Girl Reported Missing
5. To Ape or Not To Ape? Bridging Missing Links in Medical Research
6. Missing Medical Store Owners Body Found
7. Needles Given To Drug Addicts Go Missing In Scotland
8. Missing Chromosomes Revealed Brain Tumor Therapy Effect – Research Find
9. Tourists Face Health Risks by Missing Vaccinations
10. Missing Your Daily Vegetables Takes out Years of Your Life
11. Artificial Teeth Developed to Replace Missing Teeth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2017)... Palo Alto, CA (PRWEB) , ... ... ... Translations, a provider of translation and localization services for life science companies, ... testing and inspection organization, TÜV SÜD America. ISO 17100 is the globally ...
(Date:1/23/2017)... ... 2017 , ... DMG Productions is proud to announce the ... to broadcast Saturday, January 28, 2017 at 5:00pmEST. , This segment will educate ... the limitations of fatigue monitoring technologies within the mining industry. Today SmartCap is ...
(Date:1/23/2017)... ... 23, 2017 , ... Wooden and plastic balance boards have been around since at least the ... Board is the first and only balance board to use a patent-pending design featuring ... at the same time as well as skill-level adjustable for all ages and abilities. ...
(Date:1/23/2017)... ... January 23, 2017 , ... Sharon Kleyne, America’s leading water researcher, advocate ... about the benefits of making new water infrastructure a number one priority. “As we ... we expect water infrastructure to become a top priority of our new political change ...
(Date:1/23/2017)... ... January 23, 2017 , ... Zachary Cattell, President of the ... healthcare industry expert at the 2017 Sector Summit hosted by Ivy Tech Community ... host Gerry Dick, will feature an employer and an association representative from five ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... 2017 A new Transparency Market Research report ... valued at US$0.53 bn in 2013 and is predicted to touch ... between 2014 and 2022. The title of the report is "Non-invasive ... Growth, Trends and Forecast 2014 - 2022." ... Non-invasive prenatal testing (NIPT), also referred to ...
(Date:1/23/2017)... Januar 2017  ResMed (NYSE: RMD ), ... Medical ( Winter Haven, Florida ) gaben ... die Beilegung aller globalen Rechtsstreitigkeiten zwischen den Parteien geeinigt ... ihrer bestehenden Produkte im Tausch gegen Lizenzgebühren an ResMed ... leisten, um das in Florida ...
(Date:1/23/2017)... -- Just two weeks remain until legal experts and senior industry leaders ... Central London to discuss the flow of pharmaceutical products post ... Parallel Trade 2017 . In the run up to the ... available to read in the event download centre . ... Some of those confirmed include: ...
Breaking Medicine Technology: