Navigation Links
Missing Molecule Has Important Role in a Developmental Brain Abnormality

A molecule that is part of a complex signaling network in the developing brain plays //a critical role in periventricular heterotopia (PVH), a congenital brain malformation, Yale School of Medicine researchers report in Neuron.

PVH often leads to a variety of neurological disorders such as epilepsy, mental retardation, and learning or memory deficits. It has many environmental and genetic causes, but is most commonly due to mutations in the gene Filamin-A. Pasko Rakic, professor and chair of neurobiology, director of the Kavli Institute for Neuroscience, and senior author of the study, said that up until now the molecular mechanisms that regulate Filamin-A in the brain are not well understood. This study shows that the molecule MEKK4 regulates Filamin-A and its loss contributes to PVH. “We show that MEKK4 deficiency leads to both a breakdown in the lining of the fetal ventricles and abnormally high levels of Filamin-A within the proliferative areas,” Rakic said. Using advanced molecular methods, the researchers showed that the loss of MEKK4 can result in an excess of Filamin-A, and inhibit neuronal migration. The grey matter of human cerebral cortex contains over two billion neurons, but none of them are produced in the cortex itself. Cortical neurons are born near the lining of the fluid-filled ventricles deep within the fetal brain and after their last division migrate to their increasingly distant final destination in the outer cortex. To do this, migrating neurons must climb along transient scaffold of radial glial fibers that span the developing cortex. “Upon reaching their final destination, neurons stop migrating and establish specific connections with other neurons,” Rakic said. “This is a dynamic and complex process that, in humans, occurs during gestation over many months and is regulated by numerous molecules, especially by those that control nuclear and cell body movement.” The Filamin-A protein binds and organizes the intrace llular contractile protein called actin, which is essential for neuronal migration. It was reported in this study that MEKK4 is important for maintaining the correct level of Filamin-A and the integrity of the ventricular surface lining, both of which contribute to the pathogenesis of PVH. Co-authors include Matt Sarkisian, Christopher Bartley, Hongbo Chi, Fumihiko Nakamura, Kazue Hashimoto-Torii, Masaaki Toril, and Richard Flavell, chair and professor of immunobiology.

Source-BioBioTechSRM
'"/>




Related medicine news :

1. Gene linked to Missing Eye condition in newborns
2. Missing Protein In Cancer Development
3. Missing teeth associated with blocked arteries
4. Diabetic Girl Reported Missing
5. To Ape or Not To Ape? Bridging Missing Links in Medical Research
6. Missing Medical Store Owners Body Found
7. Needles Given To Drug Addicts Go Missing In Scotland
8. Missing Chromosomes Revealed Brain Tumor Therapy Effect – Research Find
9. Tourists Face Health Risks by Missing Vaccinations
10. Missing Your Daily Vegetables Takes out Years of Your Life
11. Artificial Teeth Developed to Replace Missing Teeth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
(Date:6/24/2016)... ... ... of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a Fair Minimum Wage’ ... 2020 and then adjusting it yearly to increase at the same rate as the median ... floor does not erode again, and make future increases more predictable. , The company is ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® ... Group (TGIG), has initiated cultivation and processing operations at its production facility, and ... Nevada. , Puradigm is the manufacturer of a complete system of proactive air ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Pa. , June 23, 2016 The ... in an outpatient dialysis facility.  Treatments are usually 3 ... 6 hours per visit, including travel time, equipment preparation ... a patient, but especially grueling for patients who are ... of a skilled nursing and rehabilitation centers for some ...
(Date:6/23/2016)... 23, 2016  Experian Health, the healthcare ... the patient payment and care experience, today ... products and services that will enhance the ... offerings. These award-winning solutions will enable healthcare ... compliant in an ever-changing environment and redefine ...
(Date:6/23/2016)... -- The National Pharmaceutical Council (NPC) today announced that ... organization as its newest member.  ... and chief scientific officer, Mallinckrodt Pharmaceuticals, will serve ... of Directors. ... in support of our efforts to conduct research ...
Breaking Medicine Technology: