( eficial. However the researchers f...)Missing Chromosomes Revealed Brain Tumor Therapy Effect – Research Find,Health

eficial.

However, the researchers found little difference in survival after three years between the two groups. While the group who received chemotherapy and radiation lived nearly a year longer without evidence of the cancer growing, nearly two-thirds of those patients experienced significant toxic side effects from the treatment.

Dr. Curran explains that there was some indirect evidence that showed that individuals with these types of tumors who had chromosomal deletions fared better. When the scientists compared the patients who had deletions and those who did not, they found stunning results.

‘While finding unexpectedly that adding chemotherapy didn’t help survival, equally important was the fact that we confirmed in a multicenter trial that the 1p and/or 19q deletion was highly predictive and prognostic of patient outcome, whether the patient received radiation and chemotherapy or radiation alone,’ Dr. Curran says. ‘Whether the patient had one or both deletions, the survival is much better.’

In the same journal issue, a European team showed nearly identical results in a similar trial. Both trials showed such deletions were predictive of survival, Dr. Curran says.

‘These two studies together have shifted the way we think of anaplastic or grade three gliomas,’ he says. ‘Up until now we’ve categorized them based on histologic appearance. We are now categorizing them according to chromosomal deletion status.’

‘That’s actually more predictive than what they look like under the microscope,’ Dr. Curran says. ‘Those who have no chromosomal deletions have outcomes not all that different than the grade four glioblastomas, a much more deadly brain tumor. Those with both deletions are a totally different group of patients.’

‘Testing for chromosomal deletions should be a mandatory part now of the management of these patients based on these two trials.’

‘There has been a shift in clinical trial d
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