Navigation Links
Missing Chromosomes Revealed Brain Tumor Therapy Effect – Research Find

Study results have uncovered that missing portions of 2 chromosomes located at 1p and 19q predicted the prognosis of Brain tumor therapy//.

The senior author Walter J. Curran Jr., M.D., professor and chair of radiation oncology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, have found a paradigm shift in managing rare, malignant but treatable brain tumors also known as gliomas.

Reporting last week in the Journal of Clinical Oncology, Dr. Curran and a team of American and Canadian researchers, in conjunction with the Philadelphia-based Radiation Therapy Oncology Group (RTOG), a federally-supported clinical trials organization, found that among 289 patients with either anaplastic oligodendroglioma or anaplastic oligoastrocytoma receiving either a combination of three chemotherapy drugs with radiation or radiation alone, those whose tumors had deletions in chromosome locations 1p and 19q tended to live nearly two and a half times longer than those patients without the missing chromosome portions. The ‘median survival time’ of patients with the deletions was greater than seven years, meaning that one-half lived at least that long. For those with tumors lacking such deletions, one-half lived at least 2.8 years.

‘Leukemias used to be the only cancers where chromosomal deletions were part of the treatment decision-making process,’ says Dr. Curran, who is also clinical director of the Kimmel Cancer Center at Jefferson. ‘Now, testing for such deletions in tumors should become mandatory for at least these types of gliomas.’

In the study, 147 patients received the chemotherapy and radiation, while 142 were given only radiation. These rare, malignant tumors can be effectively treated, though seldom ‘cured’ with surgery and radiation. One controversy, explains Dr. Curran, was whether or not adding chemotherapy early in the treatment will help individuals live longer. Most thought that chemotherapy would be ben eficial.

However, the researchers found little difference in survival after three years between the two groups. While the group who received chemotherapy and radiation lived nearly a year longer without evidence of the cancer growing, nearly two-thirds of those patients experienced significant toxic side effects from the treatment.

Dr. Curran explains that there was some indirect evidence that showed that individuals with these types of tumors who had chromosomal deletions fared better. When the scientists compared the patients who had deletions and those who did not, they found stunning results.

‘While finding unexpectedly that adding chemotherapy didn’t help survival, equally important was the fact that we confirmed in a multicenter trial that the 1p and/or 19q deletion was highly predictive and prognostic of patient outcome, whether the patient received radiation and chemotherapy or radiation alone,’ Dr. Curran says. ‘Whether the patient had one or both deletions, the survival is much better.’

In the same journal issue, a European team showed nearly identical results in a similar trial. Both trials showed such deletions were predictive of survival, Dr. Curran says.

‘These two studies together have shifted the way we think of anaplastic or grade three gliomas,’ he says. ‘Up until now we’ve categorized them based on histologic appearance. We are now categorizing them according to chromosomal deletion status.’

‘That’s actually more predictive than what they look like under the microscope,’ Dr. Curran says. ‘Those who have no chromosomal deletions have outcomes not all that different than the grade four glioblastomas, a much more deadly brain tumor. Those with both deletions are a totally different group of patients.’

‘Testing for chromosomal deletions should be a mandatory part now of the management of these patients based on these two trials.’

‘There has been a shift in clinical trial d esign in the last year,’ he says. ‘Now in patients with gliomas, we are going to apply this to future study design and probably treatment recommendations based on chromosomal deletions. I think more and more centers will begin to use such diagnostic genetics.’
Source: Eurekalert
'"/>




Related medicine news :

1. Gene linked to Missing Eye condition in newborns
2. Missing Protein In Cancer Development
3. Missing teeth associated with blocked arteries
4. Diabetic Girl Reported Missing
5. To Ape or Not To Ape? Bridging Missing Links in Medical Research
6. Missing Medical Store Owners Body Found
7. Needles Given To Drug Addicts Go Missing In Scotland
8. Tourists Face Health Risks by Missing Vaccinations
9. Missing Your Daily Vegetables Takes out Years of Your Life
10. Missing Molecule Has Important Role in a Developmental Brain Abnormality
11. Artificial Teeth Developed to Replace Missing Teeth
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... Atlanta, GA (PRWEB) , ... December 07, 2016 , ... ... en route to respond to an emergency medical call when he lost control of ... injuries. After being extricated from his vehicle, he was transported to Atlanta Medical Center, ...
(Date:12/7/2016)... ... , ... Castle Dermatology Institute is now offering liquid facelifts with Sculptra ... to the face. Dr. Peyman Ghasri and Dr. Pedram Ghasri, San Fernando Valley ... rejuvenate and renew the facial appearance. , Sculptra is a highly effective injectable ...
(Date:12/7/2016)... ... 07, 2016 , ... Levels of a protein in the blood associated with ... online in the journal Radiology. , Heart disease and brain disease exact a major ... rapidly aging population. Damage to both organs often occurs at a subclinical stage, or ...
(Date:12/7/2016)... ... ... it came time to blow out his candles on his 14th birthday, Estefano Reano had ... team at Joe DiMaggio Children’s Hospital surprised his family with a phone call that ... , “He was playing at home, when we got the phone call telling us ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... from offices located in South Lyon, Dewitt, Williamston, East Lansing, Ann Arbor, and ... who needs treatment for a brain tumor. , Jason Bauer and his family ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... growth in the United States will continue in 2017, ... their December 2016 Semiannual Economic Forecast. Expectations are for ... mid-2009, as indicated in the monthly ISM ® ... sector is optimistic about growth in 2017, with revenues ... non-manufacturing sector indicates that 14 of its industries will ...
(Date:12/8/2016)... , Dec. 8, 2016  Avelas Biosciences, ... improving cancer patient care from diagnosis through treatment, ... recently completed Phase 1b study in breast cancer ... San Antonio Breast Cancer Symposium. Jonathan Unkart ... at UC San Diego Health, delivered the presentation ...
(Date:12/8/2016)... NEW YORK , Dec. 8, 2016 ... today that it will charge enterprise customers only when ... model disrupts the health and wellness sector, which typically ... Logo - http://photos.prnewswire.com/prnh/20161207/446824LOGO ... platform  combines the power of technology with the empathy ...
Breaking Medicine Technology: