Navigation Links
Mifepristone Reliable For Treating Uterine Fibroids

According to a study conducted by University of Rochester, Low doses of the drug mifepristone (also known as RU-486) shrinks the uterine fibroid tumors //and greatly improves the quality of life in women. The study results were published in the December issue of the journal, Obstetrics and Gynecology.

Leiomyoma, the medical term for uterine fibroids, affects roughly half of all women aged 35 to 49. The non-cancerous tumors cause iron-deficiency anemia due to excessive menstrual bleeding, and deeply impact the quality of life for women who have this condition. Thousands of women annually opt for hysterectomies or have the tumors removed surgically because no other medical treatment has been proven effective, the study said.

'With no approved treatment for symptomatic fibroids, this study and its findings are very significant,' said corresponding author Kevin Fiscella, M.D., M.P.H., of the Department of Family Medicine Research Program at the University of Rochester Medical Center. 'Interestingly, this is the same drug that was recently shown to prevent breast cancer in a rat model. Federal funding for research related to mifepristone should be given a high priority.'

Doctors have known from prior data that mifepristone, an antiprogestin, might help uterine fibroids. But the benefits had not been confirmed until now. The University of Rochester study is the first randomized, double blind, placebo-controlled trial of mifepristone, to establish that it can be safely used at low doses to treat uterine fibroids. Forty-two premenopausal women from western New York volunteered to participate in the clinical trial from March 2004 to March 2005.

Of the total, 22 women received mifepristone at 5 mg daily, and 20 women received an identical looking placebo pill daily, for six months. Doctors sought to evaluate physical changes as well as quality of life improvements. To assess the latter, they used a survey with a 100-point scale that as ked questions such as: 'During the past month, how distressed were you by: heavy bleeding during your menstrual period, feeling tightness or pressure in your pelvic area, or feeling fatigued'

Researchers assessed bleeding with a daily log and hemoglobin tests, and administered ultrasound and other tests to assess uterine volume and tumor size. Safety monitoring was conducted throughout the trial. The National Institute of Child Health and Human Development funded the study.

Results were dramatic. By the end of the study, for example, virtually every woman in the mifepristone group was certain she had been receiving the drug because of so many improvements - despite the study's intentional design to keep everyone 'blind' to the data and outcomes.

Here are some statistics cited by the study authors: Although quality of life measurements were the same for both groups at the start of the study, the women on mifepristone reported a 135-percent improvement in quality of life after six months, compared to a 41-percent improvement in the placebo group. Symptoms decreased in both groups, but severity was significantly less in the mifepristone group.

Blood loss also improved among women taking mifepristone. For example, hemoglobin levels went up in the treatment group from 12.0 to 13.5 g/DL, compared to a decrease in hemoglobin levels in the placebo group. At the start of the study, 11 of 22 women (50 percent) in the mifepristone group were anemic, but after six months of treatment only 2 or 22 women (9 percent) were anemic. In the placebo group anemia rose, with 9 of 22 women (45 percent) anemic at the start of the study, and 12 of 22 women (60 percent) anemic after six months.

'These very promising findings warrant replication through a large multicenter study,' the authors wrote. Further studies should evaluate whether the drug can be safely taken for longer periods, and how long after stopping the drug would regrowth of f ibroids occur. Side effects to the drug were uncommon during the University of Rochester study, but the authors noted that adverse events should be carefully monitored during follow-up studies.

A few deaths have been reported among women taking mifepristone at much higher doses (200-600 mg.) for pregnancy termination. However, medical authorities have not established a causal relationship between mifepristone and the deaths.


Related medicine news :

1. Sepsis Death Reported With Mifepristone – FDA Issues Warnin
2. Shortness Of Breath A More Reliable Indicator Of High Risk Cardiac Disease
3. Are Conventional Tests for Heart attacks Reliable?
4. Reliable Help For Smokers From Nicotine Patches and Former Smokers
5. Parents – Teen’s Most Reliable Source for Sex Educatin
6. Male Contraceptives-Soon to be Reliable and Reversible
7. Are Alternative Therapies A Reliable Alternative?
8. Cystatin C Test- A Reliable Test to Detect Chronic Health Risks
9. Doctors Find Internet A Reliable Tool For Diagnosing Diseases
10. Are Computer-aided Mammogram Reports Reliable?
11. Computer Software Less Reliable Than Radiologists Eyes in Detecting Cancerous Tumors
Post Your Comments:

(Date:11/30/2015)... ... 2015 , ... MOSI recently added two state-of-the-art augmented reality (AR) experiences from ... to their collection of interactive exhibits within the Kids In Charge! building. In collaboration ... to get closer than ever to a range of animals as they drink, sleep ...
(Date:11/30/2015)... CA (PRWEB) , ... November 30, 2015 , ... The ... grafts, strip harvesting and follicular unit extraction. These techniques and procedures have been in ... patients suffering from hair loss. While Dr. Parsa Mohebi, M.D. has utilized many of ...
(Date:11/30/2015)... ... November 30, 2015 , ... On Saturday, October 24th, ... Society held an annual fundraising event, a 5K walk known as “Making Strides Against ... for substance abuse which is also located in Battle Creek, joined in for this ...
(Date:11/30/2015)... ... , ... The presidential race normally deals with political issues of national importance ... news story when Donald Trump makes disparaging remarks about Hillary Clinton’s hairstyle? It is ... wants to admit when it comes to how people are viewed by others. , ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... According to ... James Decker made a brave but slightly unusual choice to show her Instagram followers ... her pre-pregnancy form may have been pre-mature. Saying that she didn’t “want to mislead ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Nov. 30, 2015  Kevin Smith has been ... a global pioneer in wireless monitoring of vital ... MA , Mr. Smith will be responsible ... commercial strategy.  He will also directly oversee partnering ... clinical evidence for SensiumVitals, the first early warning ...
(Date:11/30/2015)... and SAN DIEGO , Nov. 30, ... (NASDAQ: ARNA ) today announced that the U.S. ... the New Drug Application (NDA) for an extended release ... will offer patients a chronic weight management treatment in ... is currently approved as an adjunct to a reduced-calorie ...
(Date:11/30/2015)... N.H. , Nov. 30, 2015 ... that it will feature its latest solutions for ... early identification of cancer at the Radiological Society ... Chicago from November 29 ... recent product advances including iReveal®, an automated breast ...
Breaking Medicine Technology: