University of Virginia researchers have discovered that microRNAs, a form of genetic material, can function as tumor suppressors// in laboratory studies.
In the May 1 issue of Genes & Development, UVa researchers Drs. Yong Sun Lee and Anindya Dutta have shown that microRNAs can suppress the overexpression of a gene called HMGA2. This gene is related to creation of fatty tissue and certain tumors, as well as diet-induced obesity.
MicroRNA is a single-stranded RNA that is typically only 20-25 nucleotides long and is related to regulating the expression of other genes.
"Overexpression of the HMGA2 gene is an essential feature of many medically significant tumors, such as uterine fibroids," explains Dr. Dutta. "It is very exciting to realize that microRNAs have an important role in suppressing the overexpression of HMGA2. Thus, they may also have a role in causing, and perhaps curing, a disease that is responsible for the vast majority of hysterectomies in the Western world."
Studying chromosomal HMGA2 translocations that are associated with human tumors, the researchers found that, in normal cells, a microRNA called let-7 binds to the 3' end of the HMGA2 mRNA transcript and suppresses its expression in the cell cytosol. However, chromosomal breaks that shorten the 3' end of the HMGA2 transcript,and prevent let-7 binding, result in aberrantly high levels of HMGA2 expression and tumorigenesis (formation of tumors).
This paper establishes that HMGA2 is a target of let-7, and that the let-7 microRNA functions as a tumor suppressor to prevent cancer formation in healthy cells.
Source-Eurekalert/BPage: 1 Related medicine news :1
. Role Of MicroRNAs In Angiogenesis Researched2
. Use of Cellular Phones associated with Increased risk of Brain Tumors3
. Radiofrequency Energy Cooks Tumors Without Surgery4
. New Liver Tumor Treatment5
. Latest Tumor Classification More Informative6
. New Technique For Benign Breast Tumors7
. Another Treatment Option for Benign Tumors8
. Understanding The Origin Of Tumors 9
. Outpatient Treatment Possible For Patients with Uterine Fibroid Tumors10
. Stem Cells, Tumor Cells Share Similar Properties: Scope For Treatment and Prevention?11
. Lipoma Arborescens: A Rare Tumor Of The Knee