Navigation Links
MicroRNAs Can Be Tumor Suppressors

University of Virginia researchers have discovered that microRNAs, a form of genetic material, can function as tumor suppressors// in laboratory studies.

In the May 1 issue of Genes & Development, UVa researchers Drs. Yong Sun Lee and Anindya Dutta have shown that microRNAs can suppress the overexpression of a gene called HMGA2. This gene is related to creation of fatty tissue and certain tumors, as well as diet-induced obesity.

MicroRNA is a single-stranded RNA that is typically only 20-25 nucleotides long and is related to regulating the expression of other genes.

"Overexpression of the HMGA2 gene is an essential feature of many medically significant tumors, such as uterine fibroids," explains Dr. Dutta. "It is very exciting to realize that microRNAs have an important role in suppressing the overexpression of HMGA2. Thus, they may also have a role in causing, and perhaps curing, a disease that is responsible for the vast majority of hysterectomies in the Western world."

Studying chromosomal HMGA2 translocations that are associated with human tumors, the researchers found that, in normal cells, a microRNA called let-7 binds to the 3' end of the HMGA2 mRNA transcript and suppresses its expression in the cell cytosol. However, chromosomal breaks that shorten the 3' end of the HMGA2 transcript,and prevent let-7 binding, result in aberrantly high levels of HMGA2 expression and tumorigenesis (formation of tumors).

This paper establishes that HMGA2 is a target of let-7, and that the let-7 microRNA functions as a tumor suppressor to prevent cancer formation in healthy cells.

Source-Eurekalert/B
'"/>




Page: 1

Related medicine news :

1. Role Of MicroRNAs In Angiogenesis Researched
2. Use of Cellular Phones associated with Increased risk of Brain Tumors
3. Radiofrequency Energy Cooks Tumors Without Surgery
4. New Liver Tumor Treatment
5. Latest Tumor Classification More Informative
6. New Technique For Benign Breast Tumors
7. Another Treatment Option for Benign Tumors
8. Understanding The Origin Of Tumors
9. Outpatient Treatment Possible For Patients with Uterine Fibroid Tumors
10. Stem Cells, Tumor Cells Share Similar Properties: Scope For Treatment and Prevention?
11. Lipoma Arborescens: A Rare Tumor Of The Knee
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MicroRNAs Can Tumor Suppressors

(Date:7/30/2014)... The report "Peracetic Acid Market by ... Food, Water Treatment, Pulp & Paper, & Others), by ... Trends & Forecasts to 2018". Peracetic Acid Market is ... by 2019, signifying a robust growth rate of over ... market data tables and 33 figures spread through 221 ...
(Date:7/30/2014)... who were breastfed for three months or more ... chronic inflammation associated with cardiovascular and metabolic diseases, ... Washington University in St. Louis. , "This study ... for children,s health decades later," said Molly W. ... and a co-author of the study with Thomas ...
(Date:7/30/2014)... San Ramon, CA (PRWEB) July 30, 2014 ... in the ancient redwood forests of the Pomo Indians ... California. The Pomo called the river Shabaikai, meaning ‘crooked ... with its labor strife and the violence of prohibition ... Bohemian Club at Russian River. Here, the most powerful ...
(Date:7/30/2014)... 2014 The Dr. Hector P. Garcia ... announced the proposed naming of the new primary care ... Garcia Family Health Center. , The proposed 40,000 sq. ... including comprehensive chronic disease management programs, pharmacy services and ... pioneering medical home model center. , Dr. Hector P. ...
(Date:7/30/2014)... 30, 2014 Naomi Fried, PhD, ... Board of Directors of the American Telemedicine Association ... Association, which has a mission to promote professional, ... telecommunications and information technology. , “Both Naomi Fried ... possess extraordinary expertise and are well known experts ...
Breaking Medicine News(10 mins):Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 2Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 3Health News:Peracetic Acid Market Worth $664.24 Million by 2018 – New Report by MarketsandMarkets 4Health News:Birthweight and breastfeeding have implications for children's health decades later 2Health News:Bill E. Clarkson Releases Debut Fact-Based Novel, Shabaikai 2Health News:Dr. Hector P Garcia Memorial Foundation Supports New Health Care Facility 2Health News:American Telemedicine Association Welcomes Two New Members to the Board of Directors 2
... July 27 Childhood obesity causes lifelong illness, leads to ... premature death in adulthood due to medical conditions such as ... human toll, childhood obesity alone costs the nation,s health care ... To address the continued tide of obesity in children, Highmark ...
... , , MINNEAPOLIS and ST. ... recently designated Children,s Hospitals and Clinics of Minnesota,s two hospital ... has the sixth busiest pediatric emergency department in the nation ... 450 trauma cases each year. Children,s voluntarily participated in ...
... healthy behaviors will bring expenditures down, experts say , , ... States now carries the hefty price tag of $147 billion ... of all medical spending, experts report. , In fact, people ... health care -- about 41 percent more than an average-weight ...
... , , , , ... leading pharmacy automation provider, today announced the pharmacy industry,s first and ... fulfills the long-unmet need for a system that handles all the ... a fraction of the cost. , , The KL60 ...
... , , Study explores $187.1 million ... to 193 members of Congress on ... care bills , , , Members of ... up have received significantly more than their ...
... ... the field of medical implants will keynote the upcoming Materials and Processes for Medical ... ... the field of medical implants will keynote the upcoming Materials and Processes for Medical ...
Cached Medicine News:Health News:Highmark Provides Pediatricians With Resources to Combat Childhood Obesity 2Health News:Highmark Provides Pediatricians With Resources to Combat Childhood Obesity 3Health News:Children's Hospitals and Clinics of Minnesota Receive Level III Trauma Designation 2Health News:Children's Hospitals and Clinics of Minnesota Receive Level III Trauma Designation 3Health News:Almost 10 Percent of U.S. Medical Costs Tied to Obesity 2Health News:Almost 10 Percent of U.S. Medical Costs Tied to Obesity 3Health News:Kirby Lester's New KL60: The Pharmacy Industry's First and Only Compact, Fully-Automated Dispensing System 2Health News:Elected Officials Voting Against Health Reform Received 65% More in Campaign Donations From Health and Insurance Interests Than Those Voting for Reform 2Health News:Elected Officials Voting Against Health Reform Received 65% More in Campaign Donations From Health and Insurance Interests Than Those Voting for Reform 3Health News:Minnesotans to Keynote Materials for Medical Devices Conference 2
(Date:7/30/2014)... Wis. , July 30, 2014 ... developer, and marketer of over-the-counter (OTC) medicinal and ... the LipiGesic ® M name along with the ... be replaced with the trademarked name MigraPure ® ... color palette of PuraMed,s homeopathic, natural migraine pain ...
(Date:7/30/2014)... , July 30, 2014 Research and Markets ... Market - Forecasts to 2019" report to their offering. ... is estimated to grow at a lower CAGR in developed countries; ... such as China , India ... years. The growth of the hematology analyzers and reagents ...
(Date:7/30/2014)... RATON, Fla. , July 30, 2014  Today the ... for indoor and outdoor sun tanning or sun burns stating ... his statement Surgeon, General Boris Lushniak , says that ... skin types and that too much exposure to indoor and ... Center for Dermatology and Aesthetic Medicine, in Boca ...
Breaking Medicine Technology:PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 2PuraMed BioScience Rebrands its Natural Migraine Relief Medication, LipiGesic M 3Hematology Analyzers & Reagents Market - Forecasts to 2019 2Indoor and Outdoor Sun Tanning or Sun Burns Directly Linked to Deadly Melanoma Skin Cancer 2
... SAN DIEGO, Dec. 18 Ambrx Inc. today ... collaboration with Merck & Co. Inc. to,develop a ... Growth Factor 21 (FGF-21) for the treatment of ... obesity., The collaboration utilizes Ambrx,s proprietary protein ...
... Reported in Q1 2008, PALO ALTO, Calif., ... ) announced today that it has completed,its target ... with AZ-104 (Staccato(R) loxapine) in patients with migraine,headache. ... which is being,developed to treat acute agitation in ...
Cached Medicine Technology:Ambrx Enters FGF-21 Type 2 Diabetes Drug Discovery Collaboration with Merck and Co. Inc. 2Alexza Completes Target Enrollment in AZ-104 Phase 2a Clinical Trial in Migraine Patients 2Alexza Completes Target Enrollment in AZ-104 Phase 2a Clinical Trial in Migraine Patients 3Alexza Completes Target Enrollment in AZ-104 Phase 2a Clinical Trial in Migraine Patients 4
Disposable tracheostomy care tray....
... the Right Solution For Your Tracheostomy Care ... care tray features the latest components for ... infection control task. Designed by clinicians, these ... of each patient and caregiver. All of ...
... Has the Right Solution For Your Tracheostomy ... and care tray features the latest components ... important infection control task. Designed by clinicians, ... needs of each patient and caregiver. All ...
... Medline Has the Right Solution For ... tracheostomy clean and care tray features the ... of this important infection control task. Designed ... the individual needs of each patient and ...
Medicine Products: