( c a standard injection or delivered sl...)Micro-jets for Painless Needle-free Injections,Health

c a standard injection, or delivered slowly over a period of time in a similar fashion to a conventional transdermal delivery system.

The device could also be developed to incorporate multiple nozzles to facilitate higher doses.

Using insulin as a model drug for in vivo experiments with rats, the research team was able to demonstrate systemic delivery of macromolecules using their novel micro-jet injector.

Although it takes a little longer for the drug treatment to reach the bloodstream using this delivery system compared to conventional injections, the team established bioequivalence of the two methods with absolutely no adverse side effects using the new technique in contrast to the bleeding and bruising observed with traditional jet injectors.

Further research is needed to determine whether any kind of reformulation of current drugs would be required in order for them to be delivered via this new method, but the ultimate aim of the research group is to establish a technology platform that could be used for the delivery of a variety of vaccines and biotech drugs.

"The pulsed micro-jets…open up new possibilities in needle-free delivery of macromolecular drugs," say the researchers.

"Compared with hypodermic needles, they offer a needle-free and patient-compliant mode of drug administration. Compared with passive transdermal patches, they allow delivery of macromolecules, provide rapid onset, and controlled, programmable, and precise dosing."

According to the team, the devices could potentially have many applications, including systemic, programmable delivery of drugs (such as insulin for diabetes or fentanyl for pain management), delivery of small doses in superficial layers for use with vaccines, or precise local delivery into the skin which could be used for the treatment of acne or cold sores.

Further development is underway to bring the product to a stage where it is
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