Novel needle-free injections that don't cause the pain and bruising common with existing needle-free devices have been developed// by a team in California.
In a bid to confront the under-use of current needle-free methods driven by the pain and discomfort experienced by patients, a team of researchers based at University of California has developed an alternative, painless, needle-free drug delivery system in collaboration with drug delivery company StratGent Life Sciences.
The new injectors promise to potentially deliver macromolecules such as vaccines and protein therapeutics painlessly without the use of a needle, thus increasing patient comfort and compliance, as well as removing the risk of needle-stick injuries to healthcare workers.
Guided by the hypothesis that the cause of the pain and bruising from standard needle-free liquid jet injectors was the result of deep penetration of the jets of the drug into the skin, the team developed a novel injector system that minimises the depth of penetration by using pulsed micro-jets at very high speeds and very small volumes.
"The device consists of a chamber that holds the drug solution," Dr Samir Mitragotri, lead author of the research paper on the new technique that was published in the Proceedings of the National Academy of Sciences, told In-PharmaTechnologist.com.
"The chamber is connected to a nozzle that has a final diameter of about 50-100 micrometers. The chamber is fitted with a piston, which is backed up by a piezoelectric crystal, and when a voltage pulse is applied to the crystal it moves forward and pushes the piston. This, in turn, pushes the drug in the form of a small jet which penetrates into the skin."
The pulsed micro-jets are expelled at over 100 metres per second at volumes of just 2-15 nanolitres per pulse. The number of pulses can be varied according to the required drug dose, and can be delivered in quick succession to mimiPage: 1 2 3 Related medicine news :1
. More Women Are Opting For Painless Labor2
. Heart Disease Risk Can Now Be Predicted By A Painless, Non-Invasive Test3
. Painless Control Of Blood Sugar Levels When Detected Early4
. Unsafe Injections and Unclean Hand hygiene major cause of hospital infections in India5
. Leptin Injections Maintain Loss In Body Weight6
. Breast Enlargement Injections Can Lead To Breast Loss7
. Orchid gets FDA Approval for Cefotaxime Injections8
. IMA Oppose Introduction of Polio Injections9
. Insulin Tablets-No More Injections10
. Epidural Steroid Injections Do Not Provide Long Term Relief