Navigation Links
Methyl-DNA binding Proteins To Fight Cancer

Russians researchers are exploring the possibility for using Kaiso protein for early detection of cancer.

They are developing this new approach to treat intestinal cancer at the Bioengineering Centre, Russian Academy of Sciences, //under Anna Prokhorchuk's guidance jointly with American colleagues sponsored by the international CRDF foundation and the Federal Agency for Science and Innovation.

Any cancerous disease changes the genetic landscape - some genes are suppressed and others get activated, resulting in the growth of the tumor and the formation of metastases, and cancer spreads beyond the control of the immune system.

The universal mechanism that regulates genetic activity is DNA methylation, where a methyl group is joined to a section of a molecule. Special methyl-DNA binding proteins spring into action, bond with a section of the methylated DNA and suppress gene activity. One such protein that the researchers are interested in is Kaiso. They assume that this protein plays an important role in the intestine cancer development, and knowledge about it can be used for diagnostics and treatment.

First, the researchers measured the level of expression of the Kaiso protein gene in intestinal tumors in mice and in human patients. The level of expression turned out to be dozens of times higher than that in healthy organs and tissues. ‘Kaiso-zero' mice were then used which were found to be resistant to cancer. The same resistance to cancer was acquired by the mice whose DNA methylation had been suppressed by other methods.

The Kaiso protein can be potentially used for early detection of cancer, as its content in a majority of tumors is much higher than that in human healthy tissue.

Contemporary molecular methods allow the analysis of expression of dozens of genes in the cancerous tissues, and comparison of the resultant picture with the gene portrait of normal cells. Of course, the Kaiso gene is not the only one that can be used for such diagnostics. The cancer tumor is a highly heterogeneous dynamic system, which requires knowledge of almost the entire genetic profile containing 28,000 genes.

Researchers believe that there are another 10 and 30 key genes that can also serve as tumor characteristic markers. This will save resources and time, sparing the need of analyzing the entire genomic profile.

In cancer therapy, chimeric Kaiso protein could be created. The ordinary Kaiso protein (via DNA methylated binding) inhibits the work of cancer suppressor genes. However, using the same properties of the protein, it is possible to make it reinforce the work of these genes. This is what the researchers are struggling to achieve.

"There are hidden pitfalls here," explains Anna Prokhorchuk, project manager. "It is necessary to make chimeric Kaiso work only to activate cancer suppressor genes, not the other methylated DNA sequences. This is what we are working at in the Bioengineering Centre jointly with American colleagues."


'"/>




Related medicine news :

1. Understanding the RNA binding protein and its functions inside the cell
2. Levels Of Blood Proteins May Help Heart Disease Care
3. Cholesterol can be lowered using combination of Soy Proteins and Sterols
4. Neurological Disorders Overcome By Proteins
5. Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
6. NR2B Proteins Lead To Chronic Pain
7. Ape Humans? Alterations in Proteins Affects Genes.
8. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
9. Blood Clotting Disorders Linked To Three Proteins
10. Transport of Proteins Unravels the Mystery behind Neurodegenerative Diseases
11. Proteins – A New Way to Treat Childrens Muscle Diseas
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... (MRE), is pleased to be invited to the Siemens Healthineers annual customer education ... The event will take place from March 27 - 31, 2017 at ...
(Date:3/28/2017)... ... 2017 , ... The Thyroid Secret is a specialized 9-part ... program was recently launched on March 1, and Dr. Wentz discussed varied benefits ... Dr. Izabella Wentz is a licensed pharmacist and a foremost thyroid specialist. After ...
(Date:3/28/2017)... ... March 28, 2017 , ... City trips have ... World Travel Trends Report). As travelers visit both urban destinations, they are faced ... prolonged sun exposure. In response, the outdoor industry has blurred the lines between ...
(Date:3/28/2017)... , ... March 28, 2017 ... ... non-profit medical society dedicated to advancing the science and clinical practice of ... its RSSearch Patient Registry, a multi-institutional, observational registry established to standardize data ...
(Date:3/28/2017)... ... March 28, 2017 , ... Alert Sentry Group LLC., a leader in ... Response Systems), the iSAFE and the iSAFE Plus. These iSAFE products are the most ... kind, the iSAFE and iSAFE Plus offer direct GPS Location and two-way calling with ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... TAIPEI, Taiwan , March 28, 2017 /PRNewswire/ ... medical device company, is pleased to announce ... Series A investment of Panther Orthopedics, Inc., a ... pioneering innovative dynamic fixation solutions for orthopedic extremity ... market continues to expand rapidly, primarily due to ...
(Date:3/28/2017)... 28, 2017  "US Cancer Generics Market Outlook ... indicators and trend analysis related to the emergence ... pharmaceutical market in US. The report analyzes various ... on cancer generics drugs in recent years. The ... billions of dollars for various stake holders involved ...
(Date:3/28/2017)... Therapeutics, Inc. (Nasdaq: OREX ) today announced ... year ended December 31, 2016. "Last ... beginning with the re-acquisition of the rights to Contrave® ... at Orexigen demonstrated remarkable focus, executing on a myriad ... Company while rewarding us full control of our FDA ...
Breaking Medicine Technology: