Navigation Links
Methyl-DNA binding Proteins To Fight Cancer

Russians researchers are exploring the possibility for using Kaiso protein for early detection of cancer.

They are developing this new approach to treat intestinal cancer at the Bioengineering Centre, Russian Academy of Sciences, //under Anna Prokhorchuk's guidance jointly with American colleagues sponsored by the international CRDF foundation and the Federal Agency for Science and Innovation.

Any cancerous disease changes the genetic landscape - some genes are suppressed and others get activated, resulting in the growth of the tumor and the formation of metastases, and cancer spreads beyond the control of the immune system.

The universal mechanism that regulates genetic activity is DNA methylation, where a methyl group is joined to a section of a molecule. Special methyl-DNA binding proteins spring into action, bond with a section of the methylated DNA and suppress gene activity. One such protein that the researchers are interested in is Kaiso. They assume that this protein plays an important role in the intestine cancer development, and knowledge about it can be used for diagnostics and treatment.

First, the researchers measured the level of expression of the Kaiso protein gene in intestinal tumors in mice and in human patients. The level of expression turned out to be dozens of times higher than that in healthy organs and tissues. ‘Kaiso-zero' mice were then used which were found to be resistant to cancer. The same resistance to cancer was acquired by the mice whose DNA methylation had been suppressed by other methods.

The Kaiso protein can be potentially used for early detection of cancer, as its content in a majority of tumors is much higher than that in human healthy tissue.

Contemporary molecular methods allow the analysis of expression of dozens of genes in the cancerous tissues, and comparison of the resultant picture with the gene portrait of normal cells. Of course, the Kaiso gene is not the only one that can be used for such diagnostics. The cancer tumor is a highly heterogeneous dynamic system, which requires knowledge of almost the entire genetic profile containing 28,000 genes.

Researchers believe that there are another 10 and 30 key genes that can also serve as tumor characteristic markers. This will save resources and time, sparing the need of analyzing the entire genomic profile.

In cancer therapy, chimeric Kaiso protein could be created. The ordinary Kaiso protein (via DNA methylated binding) inhibits the work of cancer suppressor genes. However, using the same properties of the protein, it is possible to make it reinforce the work of these genes. This is what the researchers are struggling to achieve.

"There are hidden pitfalls here," explains Anna Prokhorchuk, project manager. "It is necessary to make chimeric Kaiso work only to activate cancer suppressor genes, not the other methylated DNA sequences. This is what we are working at in the Bioengineering Centre jointly with American colleagues."


'"/>




Related medicine news :

1. Understanding the RNA binding protein and its functions inside the cell
2. Levels Of Blood Proteins May Help Heart Disease Care
3. Cholesterol can be lowered using combination of Soy Proteins and Sterols
4. Neurological Disorders Overcome By Proteins
5. Cancer Causing Proteins Trigger Abnormal Biochemical Reactions In Cells
6. NR2B Proteins Lead To Chronic Pain
7. Ape Humans? Alterations in Proteins Affects Genes.
8. Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus
9. Blood Clotting Disorders Linked To Three Proteins
10. Transport of Proteins Unravels the Mystery behind Neurodegenerative Diseases
11. Proteins – A New Way to Treat Childrens Muscle Diseas
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Experts from ... at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center ... care topics including advance care planning, healthcare costs and patient and family engagement. ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, ... the latter, setting the bar too high can result in disappointment, perhaps even self-loathing. ... toward their goal. , Research from PsychTests.com reveals that behind the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... San Diego, CA (PRWEB) , ... June 24, 2016 , ... ... up with the American Cancer Society and the Road To Recovery® program to drive ... care to seniors and other adults to ensure the highest quality of life and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 Dehaier Medical Systems Ltd. ... which develops, markets and sells medical devices and wearable ... signed a strategic cooperation agreement with Hongyuan Supply Chain ... Chain") on June 20, 2016, to develop Dehaier,s new ... cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s sales ...
(Date:6/24/2016)...   Pulmatrix, Inc ., (NASDAQ: PULM ... announced today that it was added to the Russell ... comprehensive set of U.S. and global equity indexes on ... milestone for Pulmatrix," said Chief Executive Officer Robert ... progress in developing drugs for crucial unmet medical needs, ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Forecast to 2022" report to their offering. ... the patients with kidney failure, it replaces the function of ... patient,s blood and thus the treatment helps to keep the ... balance. Increasing number of ESRD patients & ...
Breaking Medicine Technology: