Navigation Links
Metastasis of Neuroblastoma linked to Loss Of Caspase-8 gene

The caspase-8 gene prevents the metastasis of the neuroblastoma. This research was conducted at St. Jude Children's Research Hospital and the University of California// at San Diego (UCSD).

Cancer cells that have broken itself from the main primary tumor have lost the function of this gene. Hence it is clear that caspase-8 gene is responsible for inhibiting metastasis.

Neuroblastoma is addressed to all tumors present in the nervous system. It is commonly seen in children at the age of one year. It forms about 10% of the childhood carcinomas.

When caspase-8 gene codes for the particular protein it always results in the metastasis of the tumor. The tumor is never present in the primary stage. In case of bringing back the functioning of the gene results in the containment of the spread of the tumor in the body.

The research is very important as it gives us an alternative in the treatment modalities of metastasizing neuroblastoma.

Integrins are molecules present on the surface of the cells including neuroblastoma. The main function of the Integrins molecule is that they anchor the cells with the extra cellular matrix.

Extra cellular matrix is the material present outside the cell, which gives structure to the tissue. When caspase-8 goes and binds to these Integrin molecules it triggers apoptosis.

But in case of tumor that is metastasizing the unbound Integrin molecules are free and when caspase-8 bind to it results in Integrin-mediated death (IMD). By this technique all the free and moving cancerous cells are destroyed by the Integrin molecules before they can affect another distant organ.

The research team conducted experiments using tumor cells and introducing them in the laboratory embryo models. When caspase-8 gene was blocked them the tumor cells began to spread to the lung and bone marrow.

When the neuroblastoma cells were implanted in the adult embryo models tumor metasta sis to ovary, adrenal gland, kidney and liver were seen. These metastasizing cells were tested and they were found to have lost the expression of the caspase-8 gene. But this gene did not affect the growth of the tumor cells.

One important discovery that was made is that when the gene is present a number of cells present outside the tumor underwent apoptosis. This of great value for patients suffering from metastasizing neuroblastoma as it will help in the development of new treatment modalities.
'"/>




Related medicine news :

1. Understanding Lung Cancer Metastasis
2. Preventing Bone Metastasis In Patients With Breast Cancer
3. Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis
4. New Model for understanding Tumor Metastasis
5. Breast Tumor Metastasis Stimulated by Post Pregnancy Circumstances
6. Gene That Causes Metastasis of the Primary Tumor, Identified
7. Gene Responsible For Metastasis Found By Korean Scientists
8. Metastasis Of Ocular Melanoma To Liver Can Now Be Calculated
9. Cancer cell behavior during Metastasis – New finding
10. Radiofrequency Ablation Useful in Treating Ovarian Cancer Metastasis
11. "Trojan Horse" Agent Halts Bone Metastasis in Mice
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/22/2017)... ... February 22, 2017 , ... Michael J. ... media platform connecting healthcare technology professionals and other key stakeholders with an array ... publication starting on March 1, announced Michael J. Hennessy, Jr., president of MJH ...
(Date:2/22/2017)... ... ... Social media marketing is transitioning from a singular person activity to a collaborative ... this insight and more in its latest episode of its Brains Over Brawn podcast. ... social media strategist and partner of the digital firm Med|Ed Digital Jessica Columbo. Jessica ...
(Date:2/22/2017)... Wis (PRWEB) , ... February 22, 2017 , ... ... a category by itself - the Vector™ Series Multi-Cook Oven offers up to ... oven chamber, featuring exclusive Structured Air Technology™ for unmatched evenness in cooking. Alto-Shaam ...
(Date:2/21/2017)... IL (PRWEB) , ... February 21, 2017 , ... ... connectivity solutions, has introduced five new hospital-grade power extension cords that meet the ... Services (CMS) of the 2012 edition of the National Fire Protection Association (NFPA) ...
(Date:2/21/2017)... ... February 21, 2017 , ... Ray Insurance Agencies, a Dallas ... around Tarrant County, is embarking on a six month charity event aimed at raising ... cancer. , Cancer is one of the deadliest diseases in America; more than 7.5 ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... Texas , Feb. 21, 2017  Luminex Corporation (NASDAQ: ... board of directors has authorized the initiation of a quarterly ... history. This initial cash dividend will be payable on April ... of business on March 24, 2017. The ... regular quarterly cash dividend of $0.06 to holders of its ...
(Date:2/21/2017)... NEW YORK , Feb. 21, 2017 /PRNewswire/ ... Read the full report: http://www.reportlinker.com/p04711311-summary/view-report.html ... from COPD and other respiratory diseases. Patients having ... prescribed to use oxygen concentrators. Oxygen concentrators are ... be purchased over the counter. Medical oxygen concentrators ...
(Date:2/21/2017)... , February 21, 2017 ... Technology for Adoption by Plastic Industry  ... STEER, creator ... functionalise materials in the fields of plastics, pharmaceuticals, food and ... with Merck KGaA, Darmstadt, Germany , ...
Breaking Medicine Technology: