Navigation Links
Metabolism cycle of Kala-Azar parasite revealed

Researchers have found that Leishmania parasite utilizes mannose for their metabolism// and growth different from human metabolism which requires glucose.

Associate Professor Malcolm McConville and his research team from Bio21 Institute at the University of Melbourne have found a break thorough to control the spread of the parasite Leishmania in the blood. Leishmania is found to utilize sugar mannose in the blood for their metabolism and growth and it was found that it does not use glucose for its metabolism which is used by us. So, it is possible to develop new drugs that will kill the parasites by selectively disrupting the mannose metabolism, without causing affect to the glucose metabolism in the humans.

Leishmaniasis, known as Kala-Azar in India, infects at least 12 million people worldwide, in India, Bangladesh, Nepal and parts of Africa. It usually affects the poor, and can be fatal if left untreated. It is very hard to kill these parasites, as these parasites are so similar to ours that the drugs we use kill our cells too. The parasite spreads by sand flies; the leishmania parasite infects certain white blood cells known as macrophages.

“Our discovery not only offers hope for leishmaniasis,” says Prof. McConville. “It may help us to develop drugs for many other microbial pathogens which use mannose – including those involved in malaria and tuberculosis. “In addition to providing solution to treating Kala-Azar, what would be of equal interest to a country like India is the potential this discovery provides to tackle the two other major scourges – malaria and tuberculosis,” he said.

Leishmaniasis was largely unknown in the west, recently it was found to be re-emerging there. American troops returning from Iraq have been told not to give blood for a year to prevent he possible spread of the parasite into the U.S. blood supply. Last year, the parasite was found in kangaroos in the northern Australia.

(Sou rce: The Hindu)

For More information on Incidence
of Kala-Azar in India:


Related medicine news :

1. Understanding The Link Between Movement And Metabolism
2. Adult and Children Have Varied Drug Metabolism
3. Abnormal Glucose Metabolism May Contribute to Chronic Nerve Disorder
4. Fat Metabolism Of Heart Muscles Affected By High Blood Pressure
5. A New Gene to Contribute in Insulin Metabolism
6. Glucose Sensor That Controls Glucose Metabolism Identified
7. Primitive Yeast Yields Secrets Of Human Cholesterol And Drug Metabolism
8. El Ni?o cycles linked to cholera outbreaks
9. Regular exercise linked to extended menstrual cycles
10. Massage therapy regulates sleep cycle of newborns
11. Sleep cycles may be related to metabolism
Post Your Comments:

(Date:11/25/2015)... , ... November 25, 2015 , ... ... is offering lower prices in an early celebration of the early holiday shopping ... price of $29.95 each (normally $33.95 ea). Black Friday promotional pricing is in ...
(Date:11/24/2015)... ON (PRWEB) , ... November 24, 2015 , ... New ... Williams without a referral for dental implants at her Mississauga, ON practice. ... and experienced in the placement of dental implants. , Missing teeth can lead ...
(Date:11/24/2015)... ... ... In an article published November 12th by Obesity News Today, ... are not eligible for bariatric surgery. The article explains that candidates for weight loss ... pounds overweight, or have a BMI of 35 and over with at least two ...
(Date:11/24/2015)... ... November 24, 2015 , ... Preparing for the LDT Regulation:, ... p.m. EST, , FDA has long asserted that design and manufacture ... performing the tests and do not meet the device regulations. , Come up short ...
(Date:11/24/2015)... Richey, FL (PRWEB) , ... November 24, 2015 , ... ... deems a growing epidemic as deaths from prescription opioids in the United States grew ... and cocaine. In 2013 alone, opioids were involved in 37 percent of all fatal ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 ... global pharmaceutical company, and Rugen Therapeutics, a start-up ... treatments for unmet CNS disorders and funded by ... that they have entered into an exclusive collaboration ... therapies for Autism Spectrum Disorders (ASD) and Obsessive ...
(Date:11/25/2015)... Nov. 25, 2015  Mindray Medical ... MR ), a leading developer, ... worldwide, today announced that it will ... of shareholders at the Company,s Hong Kong office ... Prince Edward West Road, Mongkok KL, Hong ...
(Date:11/25/2015)... November 25, 2015 ... addition of the  "Global Drug Device ... to their offering.  --> ... of the  "Global Drug Device Combination ... their offering.  --> Research ...
Breaking Medicine Technology: