Navigation Links
Menthol Receptor-A Thermosensitivity Determinant in Cold Temperature

According to a study in Nature by Yale School of Medicine, the University of California at San Francisco (UCSF), and the University of Wisconsin, the menthol receptor detects a wide range of cold temperatures and relays the information to the brain.

The finding solves the mystery of how important the ion channel TRPM8 is for alerting the body to cold temperatures.TRPM8 is the primary, if not sole, determinant of thermosensitivity in the cool range, the researchers noted. It also contributes to the detection of extreme cold, or temperatures below 15 C degrees.

Cold, heat, sound, light, taste, and smell are detected and converted into neural impulses through the activation of receptors, which then propagate the signal by opening an ion channel. Once the channel is open, an electrical impulse travels to other neurons.

In this paper, Sven-Eric Jordt, assistant professor of pharmacology at Yale, and colleagues, found that isolated, cultured nerve cells that express TRPM8 react to cooling stimuli, but cells cultured from mice lacking TRPM8 do not. Also, mice engineered without TRPM8 are much less sensitive to cold than mice with TRPM8.

TRPM8 does not seem to be the sole receptor responsible for detecting cold, Jordt said. The TRPM8 knockout mice sensed temperatures below 15 C degrees, which indicates the possible existence of another pathway for detecting extreme cold.


'"/>




Page: 1

Related medicine news :

1. Menthol cigarettes harder to quit than regular cigarettes
2. Detecting Cold, Feeling Pain: Study Reveals Why Menthol Fresh
3. Residential Locality, A New Determinant Factor For Weight Gain
4. Age and Socioeconomic Factors Are Strongest Determinants of Sunburn
5. DNA- A Dependable Determinant to Select Treatment Plan for Alcoholics
6. Brain Temperature Tunnel dicovered
7. Evolution influenced by Temperature change
8. Sensor Images Show Soaring Temperature and Pollution Levels in UK
9. Cooling Temperatures Help Crucian Carp
10. Substance P May Pre-empt VIP in Regulating Temperature
11. New Study Links Western Wildfires to Atlantic Ocean Surface Temperatures
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to host ... items from across the nation, this holiday-themed event will raise funds and awareness for ... The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 p.m.) ...
(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the ... to develop to enable prevention of a major side effect of chemotherapy in ... in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... been named one of Michigan’s 2017 Best and Brightest in Wellness® by Best ... in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to 2 ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/4/2017)... 4, 2017 OBP Medical , ... medical devices, today announced regulatory approval from ... (or Agência Nacional de Vigilância Sanitária (ANVISA)) to ... surgical retractor with integrated LED light source and ... and exposure of a tissue pocket or cavity ...
(Date:10/2/2017)... 2, 2017  Eli Lilly and Company (NYSE: ... the third quarter of 2017 on Tuesday, October 24, ... that day with the investment community and media to ... conference call will begin at 9 a.m. Eastern time. ... live webcast of the conference call through a link ...
Breaking Medicine Technology: