A new study has found that men with chronic gum disease periodontitis, may have an increased risk of tongue cancer, regardless of whether they smoke.

Periodontitis is an oral infection thought to be caused by bacteria, though recent evidence suggests the involvement of viruses as well.

The study was conducted by a team of researchers led by Mine Tezal at the State University of New York at Buffalo and the Roswell Park Cancer Institute, Buffalo.

As part of the study, researchers compared 51 white men with tongue cancer to 54 white men without the disease, who were treated at the cancer institute between 1999 and 2005.

Periodontitis was assessed in panoramic X-rays of the mouth by calculating the amount of bone loss in the tooth cavities (alveoli), an established measure of the diseases history and progression.

"The mean [average] alveolar bone loss was significantly higher in cancer cases compared with controls (4.21 vs. 2.74 millimetres)," the authors wrote.

"After adjusting for the effects of age, smoking status and the number of teeth, each millimeter of alveolar bone loss was significantly associated with a 5.23fold increase in the risk of tongue cancer. Other oral variables (the number of dental decays, fillings, crowns and root canal treatments) were not significantly associated with the risk for tongue cancer," the authors added.

"Considerable evidence indicates that chronic infections and persistent inflammation are associated with increased cancer risk. Although viral infections have been associated with carcinogenesis [the development of cancer], the evidence for a connection between bacterial infections and carcinogenesis is also convincing," the authors added.

Researchers concluded that periodontal viruses and bacteria could be toxic to surrounding cells and produce changes that lead directly to oral cancer, or could indirectly contribute to ca
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