omen’s Hospital and senior author of the study. “For the next three weeks, thirty minutes before each sleep episode, participants ingested either a placebo, 0.3milligrams (mg), or 5.0mg of pharmaceutical grade melatonin.”The researchers found that sleep efficiency during the six hour, 40 minute episodes was significantly higher in the groups that took melatonin during times when the body was not producing melatonin.

At those times, participants taking 5.0mg of melatonin had a sleep efficiency of 83 percent and those taking 0.3mg melatonin had a sleep efficiency of 84 percent. Sleep efficiency in both of these groups was significantly greater than that in participants taking placebo, who had a sleep efficiency of 77 percent. There was no significant difference in sleep efficiency among all participants during times when melatonin was being produced in the body.James K. Wyatt, Ph.D., lead author of the study, Diplomate, American Board of Sleep Medicine and now acting Co-Director of the Sleep Disorders Service and Research Center at Rush University Medical Center in Chicago stated, “A landmark feature of this comprehensive research was the study of 24 successive sleep episodes in the same participants, including over 1,000 sleep recordings, across a full range if circadian phases – the body’s internal 24-hour timing system. We were able to definitively show in these healthy young adults that the use of melatonin as a sleep-aid was only beneficial for sleeping when the body wasn’t already releasing its own supply of melatonin.”“These data leave little doubt about the effectiveness of melatonin in alleviating sleep disturbances when attempting to sleep at the wrong time of day, at least under laboratory conditions,” continued co-author Derk-Jan Dijk, now Director of the Surrey Sleep Research Centre, Surrey, England.Czeisler concluded: “Melatonin enabled these participants to obtain an extra half hour of sleep when they attempted to do so during the day, at a ti
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