In many parts of the world, the moral and legal aspects of abortion have become the subject of intense debate. Various methods of inducing //abortions have been used throughout history and Since 2000, medically induced abortions (MIAs) death toll have crossed five in North America, who died from toxic shock caused by a Clostridium sordellii infection. This has resulted in people questioning the safety of the combination of the drugs mifepristone and misoprostol that are usually used in MIAs.

A new review of C. sordellii infections and an accompanying editorial, both published in the Dec. 1 issue of Clinical Infectious Diseases and currently available online, place these MIA-C. sordellii deaths in perspective and help to clear up misapprehensions.

According to the review by Michael Aldape, PhD, of the Veteran's Affairs Medical Center in Boise, ID, nearly 2 million women in Europe have used mifepristone and no C. sordellii infections or deaths have been reported. Since 2000, more than 600,000 women in the United States have undergone mifepristone-induced abortion, with four reported deaths. Also, prior to the cases in the United States, one woman in Canada who had had a MIA subsequently acquired a fatal C. sordellii infection.

In addition, Dr. Aldape reviews 40 other deaths caused by C. sordellii infections. These infections most commonly followed childbirth, injection drug use, trauma, or surgery.

Dr. Aldape said, 'while there have been a handful of C. sordellii-related deaths stemming from mifepristone/misoprostol usage in the past few years, I believe the problem is more global…. There are many examples of non-gynecological infections due to C. sordellii in the literature, of which more than half were fatal.'

Beverly Winikoff, MD, MPH, of the Gynuity Health Projects organization and author of an accompanying editorial, argues against theories that there is a connection between C. sordellii infections and the dr
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