Navigation Links
Mechanical forces drive early heart development

A biomedical engineer sees the heart as a pump, plain and simple, a machine shaped by genetics and complex biomechanical forces.Larry A. Taber, professor of biomedical engineering at Washington University in St. Louis, has been probing the forces, stresses and deformations of the heart since the mid-1980s. A major focus of his work is to show that biomechanical forces may be as important as genetics in shaping the heart.//

Recently, he has developed a theory on tissue growth and morphogenesis (shape change) and applied it to understanding the developing heart in chicken embryos, which is remarkably similar to its counter-part in human. Taber is studying looping one of the most critical stages of embryo heart development, where the heart at just two days of age in chickens (three weeks in humans) bends outward and rotates to the right.

This must happen perfectly to avoid misconnections of arteries in the herat walls and holes in the heart, among other serious developmental problems. His research could help scientists better understant the roles physics and mechanics play in the developing heart and in heart defects. The heart either loops or it doesn’t, and if it loops it either goes left or right,’ and those often are the only distinctions made.

It takes 21 days to hatch a chicken; at day 1 tubes form on two sides of the embryo and come together to form one tube. At this juncture (two-and-a-half weeks in the human embryo) the heart is just starting to beat. During the second day, blood flow starts and by the third day the tube is beginning to look like a heart, with septums later forming in two different regions to create left and right ventricles on one side, and right and left atria on the other, says Taber.

It appears that regional stiffness plays a role in bending. Taber collaborator, Dimitri Vornov, a visiting scientist at Washington University, has discovered that a membrane that covers the tube may play a major role in causing the rotation to the right.Taber says engineers are just now looking at growth in mature heart. His theory will be valuable in looking at these situations. Growth occurring in the mature heart is extremely important and plays a role in adaptation to high blood pressure (thicker heart walls) and heart attack.


'"/>




Related medicine news :

1. Mechanical Heart
2. Nanotechnology at its best: Nanomotors And Mechanical Nanoswitches
3. Computer-Driven System Reduces Patient Mechanical Ventilation Time Significantly
4. Shortage of services forces delayed hospital treatment for patient.
5. Pakistan Enforces Strict Bird Flu Measures, Poultry Import Banned
6. Bankruptcy forces Hospital staff to Call For County Takeover
7. Multiple deaths forces cancer trial to be called off
8. Sleepy drivers increase road death toll
9. Dyslexia may slow a drivers reaction time as much as moderate drinking!!
10. Study suggests symptom driven therapy for adults with asthma
11. Peppermint or cinnamon smell can make drivers more alert
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... , ... February 05, 2016 , ... Love is in ... in a variety of colors, assortments and packaging. This staple for Valentine’s Day is ... Kullen location. , For Valentine’s Day, not only are long-stem roses available, but ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... franchisees of Popeyes Louisiana Kitchen restaurants, launched the 14th annual “Appetite for a ... and adults with muscular dystrophy, ALS and related diseases that severely limit strength ...
(Date:2/5/2016)... ... 05, 2016 , ... The Lymphoma Research Foundation (LRF) – ... serving the lymphoma community through a comprehensive series of education programs, outreach initiatives ... Tasting Event at the La Gorce Country Club in Miami Beach on March ...
(Date:2/5/2016)... ... February 05, 2016 , ... Give To Cure today announced ... and donate to Give To Cure’s campaign that is crowdfunding clinical trials to help ... and share payments through a smart device. In 2015 alone, Venmo processed $7.5 billion ...
(Date:2/5/2016)... ... 05, 2016 , ... Stuart Bentkover, MD, FACS is thrilled to ... the most effective tattoo removal today, Dr. Bentkover is the only doctor in Central ... the PicoSure has been approved by the Food and Drug Administration (FDA) as a ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... a medical devices company, is one of five recipients to ... Terry McAuliffe,s office. ivWatch will be receiving the STEM ... to be held at the Science Museum of ... that have made significant contributions to science. ... ivWatch ...
(Date:2/5/2016)... Feb. 5, 2016 ... of the "Global Musculoskeletal Partnering 2010-2016: ... profile to their offering. --> ... of the "Global Musculoskeletal Partnering 2010-2016: ... profile to their offering. --> ...
(Date:2/5/2016)... BEIJING , Feb. 5, 2016 ... ("Dehaier Medical" or the "Company"), which develops, markets ... products in China and ... restructuring plan which aims to concentrate the Company,s ... wearable sleep respiratory business and to focus more ...
Breaking Medicine Technology: