Navigation Links
Measuring disseminated cancer cells in bone marrow - valuable tool for detecting early breast cancer metastasis

Stephan Braun and colleagues have reported in the New England Journal of Medicine, that the detection of disseminated tumor cells in bone marrow samples is a more reliable determinant of metastasis and patient survival. //

The disease progression is measured by taking biopsy samples from breast cancer patients and the level of lymph node metastases is measured to determine the disease prognosis. But research results as shown that 30% of patients with lymph node negative status still develop metastatic disease. A new approach to overcome this has been found in which the detection of micrometases in bone marrow is detected which can be a better clinical tool for early detection of disease metastasis.

Breast tumor cells frequently bypass the lymph nodes and disseminate directly through the blood to distant organs. This Hematogenous dissemination of cancer cells has been shown to be an early event in tumor progression. Analysis of data from 9 studies involving 4,703 patients with stage I, II or III breast cancer, the authors evaluated the association between detection of bone marrow micrometastases and patient outcome over a 10 year period.

The study compared the effects of different factors, such as tumor size, grade, bone marrow metastasis, lymph node metastasis and hormone receptor expression , and revealed that the presence of micrometases in bone marrow were the best predictors of outcome within the first 5 years after diagnosis. Bone marrow micrometastases were detected in over 30% of patients and these patients were found to develop larger tumors with a higher histological grade that more frequently metastasized to other organs.

Patients with bone marrow micrometastases were more likely to die of the disease, even among patients that received adjuvant therapy. In patients with very small tumors without lymph node metastases, and who therefore did not receive adjuvant therapy, the presence of bone marrow micrometastase s was also associated with shorter survival times. This procedure of detecting bone marrow micrometastases could be a complementary approach to lymph node biopsies in determining which patients should receive adjuvant therapy.

Source: Nature Review Cancer.
'"/>




Related medicine news :

1. Measuring Death Risk in COPD Patients
2. Measuring Exercise Capacity To Predict Heart Disease
3. A Novel Method For Measuring Interstitial Fluid Pressure In Cancer Tissues
4. Measuring Urinary Protein Helps In Detecting Recurrent Bladder Cancer
5. New Method For Measuring Dyskinesia In Parkinsons Being Developed
6. Measuring the Quantity of Information Passed on From the Eye to the Brain
7. Measuring Calcium Intake Help to Identify Osteoporosis in Prostate Cancer Patient
8. Vitamin B12 can help in detecting cancers
9. Want skin cancer? Please have a cigarette
10. New hope for cancer victims – will vaccine cure the deadly bug
11. Clintons new problem - Is the outgoing American president suffering from skin cancer?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... ... , ... Amir Qureshi, MD is the first physician in Arkansas to implant ... The Nuvectra™ Algovita SCS System has been FDA approved as a treatment option for ... to introduce the most powerful SCS system and the only stretchable lead on the ...
(Date:5/26/2017)... , ... May 26, 2017 , ... ... first ever copper, antimicrobial, mesh back 24/7 task chair specifically designed for clinical ... “We are thrilled to partner with Cupron® to provide customers with a ...
(Date:5/26/2017)... Illinois (PRWEB) , ... May 26, 2017 , ... Silver ... The community, which is located on more than four acres of land at 5620 ... independence. , The 103,000 square-foot building includes 125 studio and one-bedroom apartments. Each ...
(Date:5/26/2017)... ... ... to the Cross”: the personal journey of Bob Massey and his faith in the Lord. ... and Margaret Massey. Bob Massey is small in stature but big in character. ... love for others is apparent in all of his life decisions. , “I’m in ...
(Date:5/26/2017)... ... 26, 2017 , ... Water damage to the flooring of several classrooms at ... education officials with a number of critical issues to address before students could return ... accomplished with little or no disruption to class schedules. Second, the project had to ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... 2017 Zimmer Biomet Holdings, Inc. (NYSE and ... announced it has earned a spot on Forbes, ... Company was ranked among 500 U.S. employers as well ... Equipment and Services. The annual Forbes ... independent survey of over 30,000 employees across 25 industries. ...
(Date:5/8/2017)... -- MACRA replaces the outdated sustainable growth rate ... Black Book Research crowdsource-surveyed 8,845 physician practices from February ... for MIPS Compliance Technology is Booming ... or more clinicians seek to buy Merit-Based Incentive Payment ... of the changes, the hunt is on for the ...
(Date:5/6/2017)... May 5, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), ... 100,000 square feet to its Welch Allyn campus. ... commitment to bring more than 100 new jobs to ... Allyn has maintained a significant presence for more than ... new positions, a large portion of which will be ...
Breaking Medicine Technology: