Navigation Links
Measuring disseminated cancer cells in bone marrow - valuable tool for detecting early breast cancer metastasis

Stephan Braun and colleagues have reported in the New England Journal of Medicine, that the detection of disseminated tumor cells in bone marrow samples is a more reliable determinant of metastasis and patient survival. //

The disease progression is measured by taking biopsy samples from breast cancer patients and the level of lymph node metastases is measured to determine the disease prognosis. But research results as shown that 30% of patients with lymph node negative status still develop metastatic disease. A new approach to overcome this has been found in which the detection of micrometases in bone marrow is detected which can be a better clinical tool for early detection of disease metastasis.

Breast tumor cells frequently bypass the lymph nodes and disseminate directly through the blood to distant organs. This Hematogenous dissemination of cancer cells has been shown to be an early event in tumor progression. Analysis of data from 9 studies involving 4,703 patients with stage I, II or III breast cancer, the authors evaluated the association between detection of bone marrow micrometastases and patient outcome over a 10 year period.

The study compared the effects of different factors, such as tumor size, grade, bone marrow metastasis, lymph node metastasis and hormone receptor expression , and revealed that the presence of micrometases in bone marrow were the best predictors of outcome within the first 5 years after diagnosis. Bone marrow micrometastases were detected in over 30% of patients and these patients were found to develop larger tumors with a higher histological grade that more frequently metastasized to other organs.

Patients with bone marrow micrometastases were more likely to die of the disease, even among patients that received adjuvant therapy. In patients with very small tumors without lymph node metastases, and who therefore did not receive adjuvant therapy, the presence of bone marrow micrometastase s was also associated with shorter survival times. This procedure of detecting bone marrow micrometastases could be a complementary approach to lymph node biopsies in determining which patients should receive adjuvant therapy.

Source: Nature Review Cancer.
'"/>




Related medicine news :

1. Measuring Death Risk in COPD Patients
2. Measuring Exercise Capacity To Predict Heart Disease
3. A Novel Method For Measuring Interstitial Fluid Pressure In Cancer Tissues
4. Measuring Urinary Protein Helps In Detecting Recurrent Bladder Cancer
5. New Method For Measuring Dyskinesia In Parkinsons Being Developed
6. Measuring the Quantity of Information Passed on From the Eye to the Brain
7. Measuring Calcium Intake Help to Identify Osteoporosis in Prostate Cancer Patient
8. Vitamin B12 can help in detecting cancers
9. Want skin cancer? Please have a cigarette
10. New hope for cancer victims – will vaccine cure the deadly bug
11. Clintons new problem - Is the outgoing American president suffering from skin cancer?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is ... a fitness app. The fitness app plans to fix the two major problems leading the ... one size fits all type program , They don’t eliminate all the reasons ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the ... several important health care topics including advance care planning, healthcare costs and patient ...
(Date:6/25/2016)... ... ... temporary closing of Bruton Memorial Library on June 21 due to a possible lice infestation, ... aspect of head lice: the parasite’s ability to live away from a human host, and ... necessary one in the event that lice have simply gotten out of control. , As ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... , ... June 25, 2016 , ... ... and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures as a ... area —Johnson is one of the first doctors to perform the treatment. Orthobiologics ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
(Date:6/23/2016)... , June 23, 2016 Research and ... News Issue 52" report to their offering. ... influenza treatment creates a favourable commercial environment for MedImmune to ... patient base that will serve to drive considerable growth for ... would serve to cap sales considerably, but development is still ...
(Date:6/23/2016)... and INDIANAPOLIS , June 23, ... a Lilly Diabetes Tomorrow,s Leaders Scholarship is any indication, ... winners, announced today online at www.diabetesscholars.org by ... 1 diabetes stand in the way of academic and ... the Foundation,s scholarship program since 2012, and continues to ...
Breaking Medicine Technology: