Navigation Links
Measuring disseminated cancer cells in bone marrow - valuable tool for detecting early breast cancer metastasis

Stephan Braun and colleagues have reported in the New England Journal of Medicine, that the detection of disseminated tumor cells in bone marrow samples is a more reliable determinant of metastasis and patient survival. //

The disease progression is measured by taking biopsy samples from breast cancer patients and the level of lymph node metastases is measured to determine the disease prognosis. But research results as shown that 30% of patients with lymph node negative status still develop metastatic disease. A new approach to overcome this has been found in which the detection of micrometases in bone marrow is detected which can be a better clinical tool for early detection of disease metastasis.

Breast tumor cells frequently bypass the lymph nodes and disseminate directly through the blood to distant organs. This Hematogenous dissemination of cancer cells has been shown to be an early event in tumor progression. Analysis of data from 9 studies involving 4,703 patients with stage I, II or III breast cancer, the authors evaluated the association between detection of bone marrow micrometastases and patient outcome over a 10 year period.

The study compared the effects of different factors, such as tumor size, grade, bone marrow metastasis, lymph node metastasis and hormone receptor expression , and revealed that the presence of micrometases in bone marrow were the best predictors of outcome within the first 5 years after diagnosis. Bone marrow micrometastases were detected in over 30% of patients and these patients were found to develop larger tumors with a higher histological grade that more frequently metastasized to other organs.

Patients with bone marrow micrometastases were more likely to die of the disease, even among patients that received adjuvant therapy. In patients with very small tumors without lymph node metastases, and who therefore did not receive adjuvant therapy, the presence of bone marrow micrometastase s was also associated with shorter survival times. This procedure of detecting bone marrow micrometastases could be a complementary approach to lymph node biopsies in determining which patients should receive adjuvant therapy.

Source: Nature Review Cancer.
'"/>




Related medicine news :

1. Measuring Death Risk in COPD Patients
2. Measuring Exercise Capacity To Predict Heart Disease
3. A Novel Method For Measuring Interstitial Fluid Pressure In Cancer Tissues
4. Measuring Urinary Protein Helps In Detecting Recurrent Bladder Cancer
5. New Method For Measuring Dyskinesia In Parkinsons Being Developed
6. Measuring the Quantity of Information Passed on From the Eye to the Brain
7. Measuring Calcium Intake Help to Identify Osteoporosis in Prostate Cancer Patient
8. Vitamin B12 can help in detecting cancers
9. Want skin cancer? Please have a cigarette
10. New hope for cancer victims – will vaccine cure the deadly bug
11. Clintons new problem - Is the outgoing American president suffering from skin cancer?
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... ... May 24, 2016 , ... ... web-based software module. The cutting-edge feature provides end users with an embedded, ... self-service business intelligence solution and its analytics engine. , This powerful ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... alkaline water, a revolutionary new beverage for pregnant women to prevent morning sickness ... vitamins and alkaline minerals with the look and taste of water. , “Imagine ...
(Date:5/23/2016)... ... May 23, 2016 , ... Edward D. Buckingham, M.D . is ... Physicians. The annual roster is put out by the National Consumer Advisory Board to ... outstanding care are considered for this award. , The National Consumer Advisory Board (NCAB) ...
(Date:5/23/2016)... , ... May 23, 2016 , ... According to an ... in an exuberant mood since the birth of her son, Rockwell Lloyd Liu, and ... ever had.” The “Elementary” and “Kill Bill” star explains that, as a career oriented ...
(Date:5/23/2016)... ... May 23, 2016 , ... ... objectification, according to Georgia State University researchers. , In a recent ... fifth, sixth and seventh grades shared their experiences with strained relationships, recurring ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... Dutch surgeons have launched a ground-breaking medical app to ... patients on a global scale. Medical professionals from Europe ... and the US have already signed up for the app, ... totally secure environment. Education  "Imagine a doctor ... a surgeon at Harvard to treat a bomb victim via live ...
(Date:5/24/2016)... 2016 Een app die artsen ... collectief patiënten kunnen behandelen, hun kennis kunnen delen en ... de nieuwe en revolutionaire MDLinking App, ontwikkeld door een ... dr. Hans Flu en oncologisch chirurg dr. Gijs ... is, wordt op dinsdag 24 mei officieel gepresenteerd op ...
(Date:5/23/2016)... 23, 2016 According to ... Market by Product (Wheelchair, Scooters, Medical Beds, Bathroom ... Critical Care, Wound), Accessories (Lifting, Transfer) & by ... published by MarketsandMarkets, the patient handling equipment market ... 2021 at a CAGR of 10.5% during the ...
Breaking Medicine Technology: