Navigation Links
Mayo Clinic Study Finds Heart Transplant Patients Benefit from New Approach to Immunosuppression

A new immunosuppression regimen for heart transplant patients can improve kidney function and prevent transplant coronary artery disease//, according to two new Mayo Clinic studies. Mayo researchers will report their findings on April 26 at The International Society for Heart & Lung Transplantation Annual Meeting and Scientific Session in San Francisco.

Heart transplant patients are required to take daily immunosuppressive medication to prevent their body from rejecting the transplanted organ. Standard practice has been to treat patients primarily with calcineurin inhibitors. However, calcineurin inhibitors are a major cause of kidney dysfunction and do not prevent transplant coronary artery disease, a rapidly progressing coronary disease that develops in many heart transplant recipients and greatly limits long-term survival.

"Immunosuppression for heart transplant patients using calcineurin inhibitors has been essentially unchanged for 25 years, and the results have not been ideal," says Sudhir Kushwaha, M.D., the lead author and a cardiologist at Mayo Clinic. "Five to 10 years post-transplant, 10 percent of patients are on dialysis or need a kidney transplant. And 10 years post-transplant, 50 percent of patients are either waiting for another heart transplant because of coronary artery disease or have died as a result of it."

Dr. Kushwaha and a team of Mayo Clinic researchers collaborated to study alternative options for immunosuppression, using sirolimus, an anti-proliferative immunosuppression drug with potent anti-rejection properties.

One study involving 78 heart transplant patients over four years found that gradually transitioning stable patients from calcineurin inhibitors to sirolimus showed consistent improvement of kidney function. There was no increase in rejection of the transplanted heart and no difference in heart function.

A second study found gradual transition to sirolimus in 29 patients also greatly impaired the development of the proliferative changes found in transplant coronary artery disease.

"Based on our findings, patients should still receive calcineurin inhibitors as the primary immunosuppressant immediately after transplant, and the conversion to sirolimus must be gradual in order to prevent rejection," says Dr. Kushwaha. "Today, standard practice at Mayo Clinic is to consider converting all heart transplant patients from calcineurin inhibitors to sirolimus at six months post-transplant if there are no contraindications."

Source-Eurekalert/M
'"/>




Related medicine news :

1. Clinical trials need to be more frank
2. Physicians Lack Clinical Guidelines For Treating Elderly With Multiple Illnesses
3. The Growing Rise In Clinical Research Could Lead To A Compromise In Quality Of Research And Ethics
4. Clinical Comparisons Between ADHD Drugs Are Less
5. Specialized Clinics For Manipurs AIDS Patients
6. A Novel System For Clinical Banking Of Umbilical Cord Blood
7. Clinical Renal Trails Do Not Have Sufficient Women Participants
8. Clinical Trials of New Drug Febuxostat Show Promise in Gout Treatment
9. Clinical Trials Of New Anti-Cancer Drug To Be Initiated In New Zealand
10. Green Tea Consumption Found To Improve Clinical Outcome In Cancer Patients
11. Cancer Clinical Research in India
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/25/2016)... ... May 25, 2016 , ... ... compare outcomes of injured workers across 15 states. The outcomes examined in these ... access to medical care, and satisfaction with medical care. , “The goal of ...
(Date:5/25/2016)... ... , ... Cheryl Bowker of Bowker Insurance Group has been presented with one ... Award. McKenna ran one of Allstate’s most successful agencies for 48 years, but it ... him. The award named for him is not given every year, but only when ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... Casa Velas, ... restorative properties of precious stones to complement its new wellness suites . The ... floors and feature a plethora of special services and insuite amenities, from a custom ...
(Date:5/25/2016)... ... 2016 , ... Laser Skin & Wellness Center is excited to ... of female aging. The Juliet™ procedure helps to reverse the effects ... laxity, itchiness and pain have reported real relief from these and other problems by ...
(Date:5/25/2016)... ... ... First Choice Emergency Room , the largest network of independent freestanding emergency ... of its new DeSoto facility. , “We are pleased to announce Dr. Nguyen ... M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. , Dr. Nguyen ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... NORTH CHESTERFIELD, Va. , May 25, 2016 ... commercially-available next-generation sequencing test for wounds and infections. ... fungi, ALL parasites, and select viruses. The test ... infected area. David G. ... advanced molecular testing to facilitate wound healing: "We ...
(Date:5/25/2016)... 25, 2016 MedDay, a biotechnology company ... an oral presentation entitled "High doses of biotin in progressive ... be given by Professor Ayman Tourbah , Principal Investigator ... the European Academy of Neurology (EAN) in Copenhagen, ... 3" will take place on Sunday, 29 May 2016 from ...
(Date:5/25/2016)... , May 25, 2016 ... 2016"market research report that provides an overview on ... analysis at various stages, therapeutics assessment by drug ... (RoA) and molecule type, along with latest updates, ... reviews key players involved in the therapeutic development ...
Breaking Medicine Technology: