Navigation Links
Maxygen Initiates Phase IIa Clinical Trial of MAXY-G34 in Breast Cancer Patients

Maxygen, Inc. today announced that it has initiated a phase IIa trial to evaluate the efficacy, safety and tolerability of MAXY-G34 in the treatment of chemotherapy-induced neutropenia . MAXY-G34 is a novel pegylated granulocyte colony stimulating factor (PEG-GCSF) shown in preclinical and Phase I studies to have novel and potentially superior properties compared to the current PEG- GCSF therapy.

"Patients and physicians have limited options for treatment of neutropenia," said Russell Howard, chief executive officer of Maxygen. "With MAXY-G34, we hope to expand those options and improve the outcome for many chemotherapy patients. During this first Phase II trial we will begin to learn more about how our drug might play a role in the large, undifferentiated GCSF market."

The Phase IIa trial, which will be conducted at multiple centers in Eastern Europe, is the first trial of MAXY-G34 in patients. Approximately 30 patients with Stage I-III breast cancer will undergo TAC (docetaxel, adriamycin and cyclophosphamide) chemotherapy followed by next-day administration of either MAXY-G34 or Neulasta (control population). The trial is designed as a multiple ascending dose study, with planned doses at 10, 30, 60, or 100 micrograms per kilogram of MAXY-G34 compared to 6mg of Neulasta. Both MAXY-G34 and Neulasta will be administered as a single subcutaneous injection once per chemotherapy cycle.

The primary objective of the Phase IIa trial is to identify one or more doses of MAXY-G34 that effectively treat chemotherapy-induced neutropenia. Patient tolerability, safety, and immunogenicity will be monitored and assessed. Data will also be collected on the pharmacokinetic properties of MAXY-G34 and the mobilization of CD34+ stem cells.

Phase I Results

A Phase I trial was previously conducted to assess the safety and tolerability of MAXY-G34 in 40 healthy volunteers. This study showed MAXY-G34 to be a potent
'"/>




Page: 1 2

Related medicine news :

1. Bird Flu: Orissa Initiates Protective Measures
2. Biota Initiates Drug Testing War against Common Cold
3. Russia Initiates Mass Vaccination Of Poultry To Restrict Bird Flu
4. Government Initiates A Program To Curb HIV
5. Alteon Initiates Phase 2 Trial of ALT-2074 in Diabetes and Haptoglobin 2-2
6. Peregrine Pharmaceuticals Initiates Patient Enrollment In New Cotara(R) Brain Cancer Trial
7. SARS-Free Taiwan to Mark End Phase of Global Fight
8. Spray on contraceptive clears Phase I trial
9. Phase 3 trials of two multi-kinase inhibitors against cancer
10. Antigenics Pharmaceuticals plans for Phase III trial of its Melanoma vaccine
11. Phase II trails of new HIV vaccine to be held in South Africa
Post Your Comments:
(Date:7/28/2014)... Camp Soaring Eagle today announced it ... Cornville, AZ. The nonprofit organization, founded in July ... to attend medically supervised camps at no cost ... a variety of programs to Arizona families and ... illnesses including: Illness Specific Camping Weekends, Illness Specific ...
(Date:7/28/2014)... WI (PRWEB) July 28, 2014 Quincy ... Prevagen® , is pleased to announce the release of ... by company president and co-founder Mark Underwood. , The ... health information, offering useful techniques for readers to improve ... as an unavoidable conclusion, The Brain Health Guide provides ...
(Date:7/28/2014)... Randy Dotinga HealthDay Reporter ... know it takes humans just milliseconds to look at someone,s ... a new study finds that certain facial features seem to ... The shape and size of the mouth, for example, appear ... are keys to attractiveness. The study findings suggest ...
(Date:7/28/2014)... Ticket Down is reliable source for ... TX at the Cotton Bowl. The 2014 Guinness International ... it is an eight team tourney. The tournament participants ... from La Liga, Serie A, English Premier League, and Superleague ... on the pitch include: Manchester United, Manchester City, Olympiacos, ...
(Date:7/28/2014)... Glutamine is the most abundant single ... be conditionally essential during times when the body undergoes ... & Immune System Support. , Having a heavy work ... supplementing with additional glutamine may be advantageous. Glutamine supplementation ... body, digestion and immune system function. Stress on the ...
Breaking Medicine News(10 mins):Health News:Camp Soaring Eagle Announces New Camp Site 2Health News:Camp Soaring Eagle Announces New Camp Site 3Health News:Quincy Bioscience Launches the Fourth Edition of The Brain Health Guide 2Health News:Facial Dimensions May Be Key to First Impressions 2Health News:Facial Dimensions May Be Key to First Impressions 3Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Cuts Ticket Prices for AS Roma vs. Real Madrid International Champions Cup Tickets 3Health News:Betancourt Nutrition Introduces Glutamine Plus with Sustamine® L-Alanyl-L-Glutamine 2Health News:Betancourt Nutrition Introduces Glutamine Plus with Sustamine® L-Alanyl-L-Glutamine 3
... ADHD who carry a specific type of dopamine ... (MPH) than those without the genotype, according to ... The findings come from the first-ever placebo-controlled ... school age children to evaluate variants of the ...
... took the banned substance were leaner and ran faster, ... hormone, a substance frequently implicated in sports doping scandals, ... shows. , Australian researchers gave 96 non-professional athletes aged ... saline placebo. Participants included 63 men and 33 women. ...
... NEW ORLEANS, LA (May 3, 2010) Researchers have ... bowel disease, while other science shows that intra-abdominal fat ... patients, and new technology shows promising results for improvements ... the studies being presented at Digestive Disease Week (DDW) ...
... 2010) The results of new research results published ... the American College of Surgeons show that a ... hospital surgical ward. Postoperative pneumonia is a ... most common infectious complication after urinary tract and wound ...
... and without symptoms, screening mammography may be inappropriate, researchers say ... under the age of 40 result in many return visits ... a new study finds. , Almost 30 percent of ... getting mammograms, although they,re not generally recommended until age 40. ...
... later outcomes, studies show , MONDAY, May 3 (HealthDay ... critical prenatal, maternal and environmental factors can be in shaping ... things, the studies found that kids who stayed glued to ... who smoked or took antidepressants during pregnancy had raised risks ...
Cached Medicine News:Health News:Research helps end guesswork in prescribing ADHD drug 2Health News:Human Growth Hormone Does Boost Athletic Performance 2Health News:Human Growth Hormone Does Boost Athletic Performance 3Health News:Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases 2Health News:Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases 3Health News:Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases 4Health News:Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases 5Health News:Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases 6Health News:Surgeons' pilot prevention program reduces incidence of postoperative pneumonia 2Health News:Effects of TV, Drug Exposures in Early Life May Be Long-Lasting 2Health News:Effects of TV, Drug Exposures in Early Life May Be Long-Lasting 3
(Date:7/29/2014)... , July 29, 2014   ... II study investigating the efficacy and safety of MSB0010718C in ... is a rare and aggressive skin cancer lacking effective treatments   ... seven cohort Phase I clinical trial for the treatment of ... EMD Serono, Inc., a subsidiary of Merck KGaA, Darmstadt, ...
(Date:7/28/2014)... -- Pharmacyclics, Inc. (the "Company") (Nasdaq: PCYC ) ... audio webcast to discuss financial results for the second quarter ... 31, 2014 at 4:30 p.m. ET. Conference ... 31, 2014 Time: 4:30 PM ET Listen via Internet: ... A webcast replay will be available on the Pharmacyclics ...
(Date:7/28/2014)... FRANCISCO , July 28, 2014  Dignity ... it has received the Get With The Guidelines®-Stroke ... improvement measures outlined by the American Heart Association/American ... Stroke is the number four cause of death ... the United States , according ...
Breaking Medicine Technology:EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 2EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 3EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 4EMD Serono Initiates Phase II Study of Anti-PD-L1 Antibody MSB0010718C in Metastatic Merkel Cell Carcinoma 5Pharmacyclics Announces Date of Conference call to discuss Financial Results for Second Quarter of 2014 2Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 2Dignity Health St. Mary's Medical Center Honored with Quality Achievement Award for Stroke Care 3
... 17 Mach 7 Technologies, a global provider of ... product distribution agreement with Data Distributing, an international leader ... the medical industry. Under the terms of the agreement, ... an Enterprise Image Management Platform, in the United States. ...
... , , ALISO VIEJO, Calif., Nov. ... executives from over 425 companies to discuss promising technology and ... the 4th Annual CA Medical Device & Investor Forum. ... from the biggest M&A transactions in Orange County history discussed ...
Cached Medicine Technology:Mach 7 Technologies and Data Distributing Sign Agreement for U.S. Distribution of Enterprise Image Management Solutions 2OCTANe's Medical Device & Investor Forum Highlights Key Trends, Investment Opportunities 2
... ORTHOSTAR table is the most ... It was designed for both ... traction with an integrated shoulder ... special purpose operating table for ...
... theatre is ready for all current and future ... design allows a quick, problem-free conversion to meet ... connected securely and sturdily to MARS through a ... should ever be a problem in spite of ...
... Exclusive, 210° Top Rotation provides ... purpose surgery. The Hercules 6700B eliminates ... during head-end procedures, while providing ample ... to sit during procedures. Removable back ...
... schaereraxis 200/300 product range includes ... been designed for the varied ... in the surgical practice, in ... A favorable price-performance ratio takes ...
Medicine Products: