Navigation Links
Maths Theory Shows Genetic Pattern of Tumour Growth

University of California, Irvine (UCI) researchers have shown how cancer cells can alter their own genetic makeup to accelerate tumour growth by using a mathematical theory.

This is the first study to show why such alterations in the genetic makeup of cancer cells occur. It provides insight into how tumours thrive, besides offering a potential foundation for future cancer treatments.

Mathematicians Natalia Komarova, Alexander Sadovsky, and Frederic Wan focused on the phenomenon of genetic instability, a common feature of cancer in which cells mutate at an abnormally fast rate, with a view to determining what can a tumour do to optimise its own growth.

The researchers say that such mutations can cause cancer cells to proliferate or to die.

It was found that tumours grow best when cancerous cells mutate to speed up malignant transformation, and then stay that way by turning off the mutation rate.

Mathematical theory can help us understand cancer. If we know what cancer is doing, we might be able to find ways to fight it, said Komarova, Associate Professor of Mathematics at UCI.

In order to determine the patter of genetic changes that leads to the most robust tumour growth, Komarova and her colleagues used a mathematical technique called optimal control theory in which they considered a tumour with set characteristics, then changed the cell mutation variable to see under which circumstances the tumour grew best.

The mutation rate serves as the control knob. Then, we can calculate mathematically how long it takes a tumour with given parameters to reach a certain size, Komarova said.

We found that at early stages of tumour growth, instability is advantageous, and later on it becomes an impediment. This explains why many tumours exhibit a high level of instability at first, and become stable later in their development, she added.

The study has be en published in the Royal Society journal Interface.


'"/>




Related medicine news :

1. Students With Sleep Disorder Symptoms Score Badly in Maths
2. Researchers Have Found Reason Why Boys are Better at Maths Than Girls
3. New Information On Virus Goes Against The Age-Old Theory
4. Controversial Theory Says DNA Can Be Pushed To "Dark States"
5. Study Refutes Theory on HIVs Effect on White Blood Cells
6. Theory of How HIV Attacks is Wrong: Study
7. Experimental treatment for Ebola Virus Shows promising results in mice
8. New Prostate Cancer Vaccine Shows Promise
9. Ebola Treatment Shows Promise
10. New Drug Shows Significant Improvement In HIV-related Heart Condition
11. Greek Study Shows Living In The Hills May Be Healthier
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/21/2017)... ... February 21, 2017 , ... Hanna Boys Center ... will be the keynote speaker at its second Professional Networking Breakfast on March ... which develops comprehensive strategies to create and expand opportunities for boys and young ...
(Date:2/21/2017)... ... , ... As recently as 2015, rhinoplasty was one of the Top 5 ... Some patients want to make a change in the appearance of their nose while ... The team at usrhinoplasty.org is expanding its article database to better inform ...
(Date:2/21/2017)... ... 2017 , ... Ray Insurance Agencies, a Dallas area firm providing asset protection ... on a six month charity event aimed at raising local support and donations that ... of the deadliest diseases in America; more than 7.5 million people die from cancer ...
(Date:2/21/2017)... ... February 21, 2017 , ... American Veterinarian™, ... medicine, will be launching its first bi-monthly issue of 2017 in February. The ... practice management, and One Health. , In making the announcement, American Veterinarian™ ...
(Date:2/21/2017)... Michigan (PRWEB) , ... February 21, 2017 , ... ... to the United States during Black History Month (officially African American History ... to many fields of American society of a diverse race of people, but ...
Breaking Medicine News(10 mins):
(Date:2/21/2017)... , Feb. 21, 2017 Research and Markets ... Devices - Global Strategic Business Report" report to their offering. ... The report provides separate comprehensive ... , Europe , Asia-Pacific , ... and forecasts are provided for the period 2015 through 2022. Also, a ...
(Date:2/21/2017)... Research and Markets has announced the addition of the ... their offering. ... research Uterine cancer Drugs Price Analysis and Strategies - 2016, provides drug ... The research answers the following questions: What are ... are they positioned in the Global Uterine cancer market? ...
(Date:2/20/2017)... Feb. 20, 2017   MedPlast, Inc. , ... industry, announced today that it has signed a ... Device Manufacturing Services business.   The acquisition broadens MedPlast,s ... a leading services provider to the world,s largest ... further expand the company,s capabilities in assembly and ...
Breaking Medicine Technology: