Navigation Links
Maths Theory Shows Genetic Pattern of Tumour Growth

University of California, Irvine (UCI) researchers have shown how cancer cells can alter their own genetic makeup to accelerate tumour growth by using a mathematical theory.

This is the first study to show why such alterations in the genetic makeup of cancer cells occur. It provides insight into how tumours thrive, besides offering a potential foundation for future cancer treatments.

Mathematicians Natalia Komarova, Alexander Sadovsky, and Frederic Wan focused on the phenomenon of genetic instability, a common feature of cancer in which cells mutate at an abnormally fast rate, with a view to determining what can a tumour do to optimise its own growth.

The researchers say that such mutations can cause cancer cells to proliferate or to die.

It was found that tumours grow best when cancerous cells mutate to speed up malignant transformation, and then stay that way by turning off the mutation rate.

Mathematical theory can help us understand cancer. If we know what cancer is doing, we might be able to find ways to fight it, said Komarova, Associate Professor of Mathematics at UCI.

In order to determine the patter of genetic changes that leads to the most robust tumour growth, Komarova and her colleagues used a mathematical technique called optimal control theory in which they considered a tumour with set characteristics, then changed the cell mutation variable to see under which circumstances the tumour grew best.

The mutation rate serves as the control knob. Then, we can calculate mathematically how long it takes a tumour with given parameters to reach a certain size, Komarova said.

We found that at early stages of tumour growth, instability is advantageous, and later on it becomes an impediment. This explains why many tumours exhibit a high level of instability at first, and become stable later in their development, she added.

The study has be en published in the Royal Society journal Interface.


'"/>




Related medicine news :

1. Students With Sleep Disorder Symptoms Score Badly in Maths
2. Researchers Have Found Reason Why Boys are Better at Maths Than Girls
3. New Information On Virus Goes Against The Age-Old Theory
4. Controversial Theory Says DNA Can Be Pushed To "Dark States"
5. Study Refutes Theory on HIVs Effect on White Blood Cells
6. Theory of How HIV Attacks is Wrong: Study
7. Experimental treatment for Ebola Virus Shows promising results in mice
8. New Prostate Cancer Vaccine Shows Promise
9. Ebola Treatment Shows Promise
10. New Drug Shows Significant Improvement In HIV-related Heart Condition
11. Greek Study Shows Living In The Hills May Be Healthier
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/31/2016)... ... ... The successful implementation of “lean manufacturing” in various fields has inspired many ... challenges compared to manufacturing environments. , In order to provide a way to ... the Lean Lab Checklist . This checklist will help users gain an overview ...
(Date:5/31/2016)... ... May 31, 2016 , ... Like jewels in a ... already know – London is home to Ontario’s leading day spa and one of ... Fayez Tamba began with a unique concept to combine spa services with hair ...
(Date:5/31/2016)... ... ... The Global Wellness Summit (GWS), an annual conference for international ... travel, spa and beauty in Europe. The organization asked its partner experts in Europe ... researchers - to forecast where wellness is headed in Europe. Predictions range from European ...
(Date:5/31/2016)... CA (PRWEB) , ... May 31, 2016 , ... WaterField ... for digital-minded professionals, announces the waxed-canvas and leather Duo Dopp Kit , the ... waxed canvas or ballistic nylon, the Duo is smartly designed for Dad’s ...
(Date:5/31/2016)... ... , ... In his latest video, renowned AstroNumerologist Jesse Kalsi ... presidential candidate Donald Trump as an example, Kalsi describes the way AstroNumerology conveys ... adding numbers up,” says Kalsi. “It is about looking at each individual number, ...
Breaking Medicine News(10 mins):
(Date:5/31/2016)... India , May 31, 2016 ... boomer population coupled with surging prevalence of deaths from chronic ... By Application, By Region, By Country): Opportunities and Forecasts (2016-2021) ... By Application Orthopaedic, Cardiovascular, Plastic Surgery, Wound Care); By Region-North ... - US, UK, Germany , ...
(Date:5/31/2016)... ZIONA, Israel , May 31, ... medicine company utilizing its proprietary plant-based rhCollagen technology for ... authorization from the Chief Scientist of Israel,s ... of its NIS 12 million development project for 2016. The ... higher than last year,s authorized grant, which totaled NIS ...
(Date:5/31/2016)... , Isansys  Lifecare, a new generation digital healthcare company, ... patient monitoring platform, as it ships more systems to hospitals in ... Scotland and Norway , ... earlier this year, is now being used in ground-breaking clinical ... new technology significantly enhances the user experience and provides higher ...
Breaking Medicine Technology: