Navigation Links
Master Regulatory Gene of Epithelial Stem Cells Identified

The skins ability to replace the tissue it sloughs off is controlled by a variety of genes. A new study from Harvard Medical School published in the May 4 issue of Cell, however, identifies a "master regulator" of this regeneration process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be the p63 gene, a close relative to the well-known tumor-suppressing p53 gene. Without p63, mutant mice run out of the regenerative epithelial stem cells. The findings also have implications for cancers of the skin, breast and prostate, which are among the most common human malignancies.

The role of p63 in epithelial stem cells has been controversial. Some studies found that p63 maintains a steady pool of the regenerative cells, while other studies argued that p63 has more to do with causing the cells to differentiate into particular types of tissue. The study, which was lead by Frank McKeon, PhD, professor of cell biology at Harvard Medical School (HMS), shows that p63s role in not in tissue differentiation but rather to impart "stemness" to the regenerative cells in these tissues.

"With the p63-lacking mice you get normal commitment and differentiation," says McKeon. "The defect is simply running out of stem cells. When you run out of stem cells, you run out of those tissues as we have seen with the mice lacking the p63 gene."

Having established that p63 was only important to the maintenance of stem cells, McKeon and his research team then used the epithelial stem cell cloning methods developed by Howard Green, MD, the George Higginson professor of cell biology at HMS, to show that p63s key function was to provide the enhanced potential of stem cells to divide.

"The fact that p63 is essential for these epithelial stem cells, while other master regulators have been identified for blood stem cells and spermatocyte s tem cells, suggests a fundamental requirement for tissue specificity of these regulators that we dont understand," says McKeon. "Dissecting the genetic programs controlled by these regulators will tell us much about how stem cells function and how they go awry in cancer."


'"/>




Related medicine news :

1. Protein acts as "Master Switch" that cuts off cells Cancer-Growth machinery
2. Master Switches Found for Adult Blood Stem Cells
3. Master Regulatory Gene of Epithelial Stem Cells Identified
4. Tumor Suppressor p53s Contradictory Regulatory System
5. Human Complexity Can Be Attributed To Regulatory Sequence
6. The Lancet Calls For Review Of Regulatory Process Of Drug Trials
7. Medtronic’s Insulin Pump Receives Regulatory Approva
8. Regulatory T-cells – Protector or Cause of Diseases
9. GMC Wrestles For Regulatory Powers
10. Regulatory Mechanism for Tumor Suppressor Protein Identified
11. Structure of Iron Regulatory Protein-RNA Complex Solved
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/18/2017)... (PRWEB) , ... August 18, ... ... d/b/a Quick International, LLC (“Quick”), a highly specialized asset-light logistics provider of ... entered into a definitive agreement to purchase Unitrans International Corporation, a division ...
(Date:8/18/2017)... NY (PRWEB) , ... August 18, 2017 , ... ... of “Vision & Hearing” campaign, advocating for active, healthy lifestyles and highlighting the ... available for individuals with hearing impairments and shares the latest innovations in hearing ...
(Date:8/18/2017)... McLean, VA (PRWEB) , ... August 18, 2017 ... ... offers asset protection services and financial consultations to communities throughout the greater DC ... Semper K9 with the goal of rescuing local animals and training them to ...
(Date:8/18/2017)... ... August 18, 2017 , ... MLM Insurance Group, a Miami ... southern Florida, is working to support the Take Stock In Children Foundation during ... families. , The Take Stock In Children Foundation (TSC) offers guidance and assistance ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Golseth Agency, a Texas based insurance management ... spearheading a regional charity campaign organized to provide support to Christina Upchurch and her ... year, Christina and her children returned from out of town to find her husband ...
Breaking Medicine News(10 mins):
(Date:7/27/2017)... Services, Inc. (NYSE: WST ) today announced ... financial guidance for the full-year 2017. ... Reported net sales of $397.6 million, a record high, ... constant currency (organic) grew by 3.9%. ... in the prior-year quarter. Second-quarter 2017 adjusted diluted EPS ...
(Date:7/26/2017)... SINGAPORE , July 27, 2017  Radium Medical Aesthetics, a ... LASEMD, designed to delay aging by effectively addressing several skin conditions ... the skin to become rougher and more fragile. The skin becomes ... the unavoidable exposure to the harmful UV rays from the sun ... hyperpigmentation. ...
(Date:7/26/2017)... , July 26, 2017 The Galien ... Prix Galien USA Award Nominees. Counted ... Prix Galien Award recognizes outstanding biomedical and technology product achievement ... To qualify, each candidate must be U.S. Food ... five years and demonstrate tremendous potential to impact human health. ...
Breaking Medicine Technology: