Navigation Links
Master Regulatory Gene of Epithelial Stem Cells Identified

The skin’s ability to replace the tissue it sloughs off is controlled by a variety of genes. A new study from Harvard Medical School published// in the May 4 issue of Cell, however, identifies a "master regulator" of this regeneration process not only for skin, but for many epithelial tissues including breast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be the p63 gene, a close relative to the well-known tumor-suppressing p53 gene. Without p63, mutant mice run out of the regenerative epithelial stem cells. The findings also have implications for cancers of the skin, breast and prostate, which are among the most common human malignancies.

The role of p63 in epithelial stem cells has been controversial. Some studies found that p63 maintains a steady pool of the regenerative cells, while other studies argued that p63 has more to do with causing the cells to differentiate into particular types of tissue. The study, which was lead by Frank McKeon, PhD, professor of cell biology at Harvard Medical School (HMS), shows that p63’s role in not in tissue differentiation but rather to impart "stemness" to the regenerative cells in these tissues.

"With the p63-lacking mice you get normal commitment and differentiation," says McKeon. "The defect is simply running out of stem cells. When you run out of stem cells, you run out of those tissues as we have seen with the mice lacking the p63 gene."

Having established that p63 was only important to the maintenance of stem cells, McKeon and his research team then used the epithelial stem cell cloning methods developed by Howard Green, MD, the George Higginson professor of cell biology at HMS, to show that p63’s key function was to provide the enhanced potential of stem cells to divide.

"The fact that p63 is essential for these epithelial stem cells, while other master regulators have been identified for blood stem cells and spermatocyte stem cells, suggests a fundamental requirement for tissue specificity of these regulators that we don’t understand," says McKeon. "Dissecting the genetic programs controlled by these regulators will tell us much about how stem cells function and how they go awry in cancer."

Source-Eurekalert
ME/B
'"/>




Related medicine news :

1. Protein acts as "Master Switch" that cuts off cells Cancer-Growth machinery
2. Master Switches Found for Adult Blood Stem Cells
3. Tumor Suppressor p53s Contradictory Regulatory System
4. Human Complexity Can Be Attributed To Regulatory Sequence
5. The Lancet Calls For Review Of Regulatory Process Of Drug Trials
6. Medtronic’s Insulin Pump Receives Regulatory Approva
7. Regulatory T-cells – Protector or Cause of Diseases
8. GMC Wrestles For Regulatory Powers
9. Regulatory Mechanism for Tumor Suppressor Protein Identified
10. Structure of Iron Regulatory Protein-RNA Complex Solved
11. Ramadoss Vows to Set Up Food Regulatory Body in India
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/2/2016)... ... , ... Further establishing itself as a leader in natural pet products category, ... were selected from over 1,000 entrants as a winner and recipient of the prestigious ... for dogs are a favorite product among pet-parents worldwide, as each whimsical knobby shape ...
(Date:5/2/2016)... ... May 02, 2016 , ... Zitter Health Insights ... Patient Satisfaction Award that will recognize specialty pharmacies for their achievements in customer ... Insights’ Specialty Pharmacy Patient Satisfaction Survey compiled throughout 2016. Results will be published ...
(Date:5/2/2016)... ... May 02, 2016 , ... Dr. Rassouli, dentist in Orange ... decline. According to the research, which was published in the “Journal of the American ... and about 5.4 million Americans have Alzheimer’s disease. The study found that dental problems ...
(Date:5/2/2016)... ... May 02, 2016 , ... Visceral fat, also known ... the kidneys, liver and pancreas. If not properly addressed, visceral fat can lead ... Internal Medicine, Medical Oncology and Palliative Care, warns against the dangers of visceral ...
(Date:5/2/2016)... (PRWEB) , ... May 02, 2016 , ... The 2016 World Ultimate & Guts Championship ... Camp at Manhattan College, made the cut. The WUGC is being held in London, England ... won the gold in the men’s division, another gold in the women’s masters division, and ...
Breaking Medicine News(10 mins):
(Date:5/2/2016)... , May 2, 2016  Deerfield announced ... financing of Graybug Vision, Inc. Graybug Vision is ... therapies that may transform care for ocular diseases ... Graybug Vision,s technology was first developed at Johns ... a startup venture. Graybug Vision ...
(Date:5/2/2016)...  While nearly three-quarters of Americans (71%) are aware ... health, only about half report taking any steps to ... a new survey announced today by Hologic (Nasdaq: ... Osteoporosis Month, Hologic is raising awareness of this major ... Americans. Osteoporosis is a disease that causes ...
(Date:5/2/2016)... May 2, 2016  Celsion Corporation (NASDAQ: ... announced data from the first cohort of patients ... (the OVATION Study) combining GEN-1, the Company,s DNA-based ... treatment of newly-diagnosed patients with advanced ovarian cancer ... debulking surgery.  In the first three patients dosed, ...
Breaking Medicine Technology: