Navigation Links
Mast Cells Suppress Immune System

Researchers at the Dartmouth Medical School have discovered a vital link that reveals how the immune system works. Their study is published online on August 20 in the journal// Nature. The researchers found that mast cells, which are involved in allergic reactions, are involved in immune system suppression.

'Our finding is a complete surprise. We were studying transplant tolerance and what's required to protect a graft from rejection,' says Randolph Noelle, professor of microbiology and immunology at Dartmouth Medical School. 'When we went looking to see what genes were responsible in a successful graft, we found high levels of mast cell gene products, which made the connection between regulatory T cells and mast cell recruitment. The fact that mast cells may be instrumental in orchestrating regulatory T cell tolerance was new, unanticipated, and surprising.'

In their study, the researchers determined that mast cells are crucial for sustaining immune suppression in transplanted skin on mice, which means longer acceptance or tolerance of the transplant. Mice that were mast cell deficient rejected the skin graft. Furthermore, the researchers found that IL-9, a protein already known for playing a role in mast cell activation and recruitment, was discovered to be produced by regulatory T cells. As such, the other key discovery in this study was that Il-9 appears to be an essential ingredient in the success of transplanted skin.

'Because of this study, mast cells are now the new cellular target in understanding immune suppression,' says Noelle, who is co-director of the Immunotherapy Program of the Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center. 'We now have a whole new set of cellular, and eventually molecular, interactions to study.'

According to Noelle, the findings might also impact some cancer treatments as mast cells are known to promote growth in some tumors. Future research might look into suppres sing mast cells to boost the immune system, which could lead to tumor rejection.

'It is only because of the extremely high quality of the graduate students in Dartmouth's Molecular and Cell Biology Program and the hard work of post-docs and colleagues that this new paradigm of cellular interactions in immunology was discovered,' says Noelle.

Source: Eurekalert
'"/>




Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Gene Therapy Destroys Pancreatic Cancer Cells
4. Stem Cells Have Few Mutations
5. Heart may pull Cells from Body to Self-repair
6. Cells critical for asthma development found
7. Vitamin D Wipes out Cancer Cells
8. Bone Marrow Cells Help Heart Attack Patients
9. Islet Cells May Lead to Diabetes CureChildren
10. Stem Cells Found To Offer Promise For Hair Growth
11. Bone Marrow Cells Could Yield A New Lease of Life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2017)... ... May 26, 2017 , ... Water damage to the flooring of several ... had left education officials with a number of critical issues to address before students ... to be accomplished with little or no disruption to class schedules. Second, the project ...
(Date:5/24/2017)... ... 24, 2017 , ... In modern research, success depends greatly ... for research and understanding the basic principles that were designed to drive that ... in stereo microscopy for brightfield and fluorescence typically used in laboratories working on ...
(Date:5/24/2017)... (PRWEB) , ... May 24, 2017 , ... Altec ... its participation in nVerge 2017 – a one-day technology conference in San Diego, CA. ... management solution, which allows users to fully utilize and enhance their Sage ERP solutions ...
(Date:5/24/2017)... ... May 24, 2017 , ... Drs. Nicholas Rallis and ... now spent 10 years as clinical instructors for the reputable Full Mouth Rehabilitation ... Through the program, private practitioners receive cutting-edge clinical training and learn how to ...
(Date:5/24/2017)... OH (PRWEB) , ... May 24, 2017 , ... Patients ... in Cortland, OH, can now meet with Dr. Joseph Bedich for a consultation, with ... while simultaneously improving their oral health and functionality. , Dr. Bedich offers ...
Breaking Medicine News(10 mins):
(Date:5/12/2017)...  The China and Canada joint tech ... water, energy and detergent, and features a powerful disinfection process. ... washing machine that washes and sanitizes women,s panties or babies, cloth ... ... does not require an external water inlet. ...
(Date:5/10/2017)... Mass., May 10, 2017 Hologic, Inc. (Nasdaq: ... results for the fiscal second quarter ended April 1, ... of $1.84 increased 666.7% compared to the prior year ... resulted in a significant gain, while non-GAAP diluted EPS ... 3.2%, or 3.8% in constant currency terms.  Excluding the ...
(Date:5/10/2017)... , May 10, 2017  The Corporate ... or employees of sleep therapy clinics to call ... sleep therapy clinic is involved in a substantial ... interested in hearing from an employee of a ... in a kickback scheme to provide medical practice groups ...
Breaking Medicine Technology: