Navigation Links
Mast Cells Suppress Immune System

Researchers at the Dartmouth Medical School have discovered a vital link that reveals how the immune system works. Their study is published online on August 20 in the journal// Nature. The researchers found that mast cells, which are involved in allergic reactions, are involved in immune system suppression.

'Our finding is a complete surprise. We were studying transplant tolerance and what's required to protect a graft from rejection,' says Randolph Noelle, professor of microbiology and immunology at Dartmouth Medical School. 'When we went looking to see what genes were responsible in a successful graft, we found high levels of mast cell gene products, which made the connection between regulatory T cells and mast cell recruitment. The fact that mast cells may be instrumental in orchestrating regulatory T cell tolerance was new, unanticipated, and surprising.'

In their study, the researchers determined that mast cells are crucial for sustaining immune suppression in transplanted skin on mice, which means longer acceptance or tolerance of the transplant. Mice that were mast cell deficient rejected the skin graft. Furthermore, the researchers found that IL-9, a protein already known for playing a role in mast cell activation and recruitment, was discovered to be produced by regulatory T cells. As such, the other key discovery in this study was that Il-9 appears to be an essential ingredient in the success of transplanted skin.

'Because of this study, mast cells are now the new cellular target in understanding immune suppression,' says Noelle, who is co-director of the Immunotherapy Program of the Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center. 'We now have a whole new set of cellular, and eventually molecular, interactions to study.'

According to Noelle, the findings might also impact some cancer treatments as mast cells are known to promote growth in some tumors. Future research might look into suppres sing mast cells to boost the immune system, which could lead to tumor rejection.

'It is only because of the extremely high quality of the graduate students in Dartmouth's Molecular and Cell Biology Program and the hard work of post-docs and colleagues that this new paradigm of cellular interactions in immunology was discovered,' says Noelle.

Source: Eurekalert
'"/>




Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Gene Therapy Destroys Pancreatic Cancer Cells
4. Stem Cells Have Few Mutations
5. Heart may pull Cells from Body to Self-repair
6. Cells critical for asthma development found
7. Vitamin D Wipes out Cancer Cells
8. Bone Marrow Cells Help Heart Attack Patients
9. Islet Cells May Lead to Diabetes CureChildren
10. Stem Cells Found To Offer Promise For Hair Growth
11. Bone Marrow Cells Could Yield A New Lease of Life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/25/2016)... ... , ... The 12th session of the Silicon Valley BioTalks will take place ... CA. This Bay Area biotech event will focus on “Setting Up Early Stage Clinical ... company Hallux, biopharma Apexigen, Contract Research Organization (CRO) Experien Group, and Electronic Data Capture ...
(Date:5/25/2016)... ... May 25, 2016 , ... “We are very pleased to ... Advisors. “Brad brings significant experience advising healthcare provider clients throughout the country. As ... implementation of MACRA, we believe that continuing to add professionals with deep experience ...
(Date:5/25/2016)... ... 25, 2016 , ... The Georgia State University College of Law new building ... Design Commission. , The annual award recognizes projects, programs, individuals and organizations that have ... of its physical heritage and the balance between the old and the new. , ...
(Date:5/25/2016)... Marne, Michigan (PRWEB) , ... May 25, 2016 ... ... abuse located in Central Michigan, has produced another video highlighting one of the ... their Martial Arts class. Sensei Ed Taylor, a 5 th Degree Black Belt ...
(Date:5/25/2016)... ... 25, 2016 , ... According to an article published May 5th on The Daily ... their breath. In fact, it found that more than a third cited unappealing breath a ... by pungent foods or a failure to brush after meals, can typically be attributed to ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... Germany and GERMANTOWN, Maryland ... (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) today ... co-development agreement with Therawis Diagnostics GmbH to develop and commercialize ... develop and market PITX2 as a marker to predict effectiveness ... cancer patients. "We are pleased to partner with ...
(Date:5/25/2016)...  According to Kalorama Information, the world market ... Though these are challenging times in the market, ... for companies that remain optimistic and seek innovation.  ... prospects medical device companies spend a higher percentage ... than do companies in other industries.  Also, in ...
(Date:5/25/2016)... CORAL SPRINGS, Florida , May 25, 2016 /PRNewswire/ ... Marijuana Business Conference & Expo earlier this month, the ... undeniable. As revenues continue to climb into the billions, ... to the newly released 4th Edition State of Legal ... New Frontier, a cannabis-focused data-analysis firm, much of the ...
Breaking Medicine Technology: