Navigation Links
Many Drug Tests on Animals are Badly Flawed, a Study Warns

A BMJ Study in six areas by team of senior scientists warns that many tests of drugs on animals// are flawed and hard to predict how well a prototype medicine will work on humans.

The British Medical Journal (BMJ) research, which looked at the studies in six areas have found that animal studies agreed with human trials in just three areas out of six.

It is believed that the high-profile London drug trial that left six men ill early this year was carried out after animal studies showed the drug TGN1412 was effective, but resulted in six men suffering from serious organ failure after taking part in a trial of the TGN1412 drug made by TeGenero.

A team of researchers from the London School of Hygiene and Tropical Medicine reviewed evidence from a wide range of human and animal trials looking at six areas of treatment. This study was led by Professor Ian Roberts and suggested that the animal studies should be used only if required.

Corticosteroids, which were used to treat head injuries and respiratory illnesses in babies, Antifibrinolytics to treat bleeding, Thrombolysis and Tirilazad for stroke and Bisphosphonates for osteoporosis. But found that there was no consistent agreement between the animal and human studies.

These drugs did not show any benefits for treating diseases, for example Corticosteroids did not show any benefit for treating head injury in clinical trials but had done so in animal models. Different results were seen for tirilazad, for which data from animal studies suggested a benefit but the human trials showed no benefit, but only possible harm. But in some cases, for example in case of osteoporosis (brittle bones) and neonatal respiratory distress, where babies struggle to breathe, the clinical trials in animals came up with the same result as the human trials.

To conclude, the researchers have called in for more systematic reviews like this one, where the results of a number of an imal trials are pooled to get a better idea on the effects of drugs.


Related medicine news :

1. The Effectiveness Of Screening Tests Questioned
2. Blood Tests Can Help Detect Osteoporosis Early In Life
3. Easier Tests To Detect Tuberculosis
4. Fragile X-Associated Tremor /Ataxia Syndrome Need Guidelines For Diagnostic Tests
5. Genetic Tests Could Become As Affordable As Blood Tests
6. Obese Adults Undergo Less Medical Tests And More Vulnerable To Diseases
7. Delay in Breast Cancer Gene Tests
8. Health Officials Inquire Into OraQuick HIV Tests
9. Move to make HIV Tests mandatory For Soldiers In Northeast
10. Punjab Government To Clamp Down On Sex Determination Tests
11. Free HIV Tests Brings Crowd to the Testing Centers
Post Your Comments:

(Date:11/26/2015)... ... 2015 , ... Somu Sivaramakrishnan announced today that he joined ... offers travelers, value and care based Travel Services, including exclusive pricing on a ... cabin upgrades and special amenities such as, shore excursions, discounted fares, travel gifts ...
(Date:11/26/2015)... (PRWEB) , ... November 26, 2015 , ... Jobs in ... by healthcare professionals and offered by healthcare staffing agency Aureus Medical Group . ... the month of October 2015 among those searching for healthcare jobs through the company’s ...
(Date:11/26/2015)... ... November 26, 2015 , ... ... process, participated in the 61st annual Employee Benefits Conference. The Employee Benefits Conference ... Sunday, November 8th through Wednesday, November 11th, 2015. The conference was held at ...
(Date:11/26/2015)... Karnataka (PRWEB) , ... November ... ... innovative online platform for mental health and wellness consultation, has collaborated with ... to holistically address their reader’s queries on topics on mental and emotional ...
(Date:11/25/2015)... ... November 25, 2015 , ... Additional ... those found on mammography, according to a study published online in the journal ... seen on mammography may necessitate a change in treatment. , Breast MRI is ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Carolina , 26 november 2015 /PRNewswire/ ... (AAIPharma/CML) kondigt de geplande investering aan van ... van de laboratoria en het mondiale hoofdkantoor ... De uitbreiding zal resulteren in extra kantoorruimte ... voldaan aan de groeiende behoeften van de ...
(Date:11/26/2015)... SAN FRANCISCO , November 26, 2015 ... 1.82 billion by 2022, according to a new report by ... as Chronic Kidney Disease (CKD) which demands kidney transplantation is ... convenient and cost effective substitute for organ transplantation. --> ... 1.82 billion by 2022, according to a new report by ...
(Date:11/26/2015)... , November 26, 2015 ... Juntendo universitetssjukhus ser potential att använda ... magnetresonansbilder (MR-bilder) för patienter med multipel ... ett forskningsavtal med SyntheticMR AB för att ... forskningsprojekt på sjukhuset. Med SyMRI kan man ...
Breaking Medicine Technology: