Navigation Links
Many Drug Tests on Animals are Badly Flawed, a Study Warns

A BMJ Study in six areas by team of senior scientists warns that many tests of drugs on animals// are flawed and hard to predict how well a prototype medicine will work on humans.

The British Medical Journal (BMJ) research, which looked at the studies in six areas have found that animal studies agreed with human trials in just three areas out of six.

It is believed that the high-profile London drug trial that left six men ill early this year was carried out after animal studies showed the drug TGN1412 was effective, but resulted in six men suffering from serious organ failure after taking part in a trial of the TGN1412 drug made by TeGenero.

A team of researchers from the London School of Hygiene and Tropical Medicine reviewed evidence from a wide range of human and animal trials looking at six areas of treatment. This study was led by Professor Ian Roberts and suggested that the animal studies should be used only if required.

Corticosteroids, which were used to treat head injuries and respiratory illnesses in babies, Antifibrinolytics to treat bleeding, Thrombolysis and Tirilazad for stroke and Bisphosphonates for osteoporosis. But found that there was no consistent agreement between the animal and human studies.

These drugs did not show any benefits for treating diseases, for example Corticosteroids did not show any benefit for treating head injury in clinical trials but had done so in animal models. Different results were seen for tirilazad, for which data from animal studies suggested a benefit but the human trials showed no benefit, but only possible harm. But in some cases, for example in case of osteoporosis (brittle bones) and neonatal respiratory distress, where babies struggle to breathe, the clinical trials in animals came up with the same result as the human trials.

To conclude, the researchers have called in for more systematic reviews like this one, where the results of a number of an imal trials are pooled to get a better idea on the effects of drugs.


'"/>




Related medicine news :

1. The Effectiveness Of Screening Tests Questioned
2. Blood Tests Can Help Detect Osteoporosis Early In Life
3. Easier Tests To Detect Tuberculosis
4. Fragile X-Associated Tremor /Ataxia Syndrome Need Guidelines For Diagnostic Tests
5. Genetic Tests Could Become As Affordable As Blood Tests
6. Obese Adults Undergo Less Medical Tests And More Vulnerable To Diseases
7. Delay in Breast Cancer Gene Tests
8. Health Officials Inquire Into OraQuick HIV Tests
9. Move to make HIV Tests mandatory For Soldiers In Northeast
10. Punjab Government To Clamp Down On Sex Determination Tests
11. Free HIV Tests Brings Crowd to the Testing Centers
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... Michigan (PRWEB) , ... June 24, 2016 , ... June ... about the dangers associated with chronic pain and the benefits of holistic treatments, ... individuals who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension ... that it will receive two significant new grants to support its work to ... its 25th anniversary by recognizing patients, medical professionals and scientists for their work ...
(Date:6/24/2016)... Francisco, CA (PRWEB) , ... June 24, 2016 ... ... CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive ... self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation ...
(Date:6/24/2016)... ... , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business ... to $12 an hour by 2020 and then adjusting it yearly to increase at the ... minimum wage, assure the wage floor does not erode again, and make future increases more ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... at the Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, ... journal articles published in Emergency Medicine Practice and Pediatric Emergency Medicine ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets has ... 52" report to their offering. ... creates a favourable commercial environment for MedImmune to enter. The ... that will serve to drive considerable growth for effective anti-influenza ... to cap sales considerably, but development is still in its ...
(Date:6/23/2016)... Calif. , June 23, 2016 ... CST on Thursday, July 7, 2016 , , , , ... ) , , , , EXPERT PANELISTS:  , , ... Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar ... The global pharmaceutical industry is witnessing an exceptional ...
(Date:6/23/2016)... announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in Bogota. Colombia ... ... ... ... Astellas is a pharmaceutical ...
Breaking Medicine Technology: