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Malignant virus in polio vaccine combined to Cancer

ia at San Francisco. ``That attitude is wrong.''

Levy said he had carefully reviewed the papers published Friday and was impressed with the research. ``You just can't walk away from it,'' he said, noting that the association found was very strong. ``But there is still quite a difference between association and causation,'' he added, ``and proving causation is very difficult.''

Dr. Adi Gazdar of the University of Texas, who led the second study, said yesterday that the ``data is very, very solid.'' He said it had to be more than coincidence that the four types of tumors found in hamsters after injection with SV40 - brain, bone, mesothelioma and lymphomas - are now exactly the same tumor types in humans found with detectable levels of SV40.

``The chances are 10 million to 1 it is a coincidence,'' he said. Evidence of how the virus works in tumors is growing as research shows that proteins from SV40 have a powerful effect in turning off tumor suppressor genes in humans.

Gazdar and the other researchers said that the recent SV40 discoveries also could help lead to effective cancer treatment, by using SV40 as a target for therapies. ``A vaccine targeting SV40 in mesothelioma is now being developed,'' he said. ``But it's still only a potential therapy, and we don't know if it will work yet.''

He said that U.S. officials have all but ignored the SV40 detections and that government funding and support for research has been nonexistent. One reason given by Gazdar and other scientists is that the government is worried about its role in promoting polio vaccination campaigns in the 1950s.

Jackie Kennedy And maybe it's because the first SV40-related cancers that were discovered were such rare ones,'' Gazdar said. ``But you can't ignore lymphoma; it's too widespread and too important a cancer. Jackie Kennedy and a lot of other well- known people have died from it.''


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