ch has also turned up SV40 in tumors of children and adults born after the contaminated vaccine was taken off the market in 1963, leading to the still-unsolved mystery of how the virus is being transmitted. Friday's reports indicate that SV40 may be involved in a much broader group of human cancers, playing a possible role in nearly half of the 50,000 new cases of non- Hodgkin lymphoma diagnosed annually.
The cancer, which can be highly aggressive, has been associated with HIV-positive patients, and it was thought that the suppression of the immune system in these patients may have had a connection with the dramatic increase in lymphomas since 1970.
The new studies examined lymphomas from HIV-positive and -negative patients. Results suggested that both groups had either about the same level of SV40 DNA fragments, or that the HIV- negative samples had a greater incidence.
The second group of researchers were at the Fred Hutchinson Cancer Research Center in Seattle and the University of Texas Southwestern Medical Center in Dallas. Remarkably, both groups of researchers using slightly different detection techniques came up with almost identical results: SV40 fragments were found in 42 percent of 154 lymphomas sampled in one study, while the other found 43 percent in 68 cases.
No virus was detected by either study in nonmalignant lymphoid samples and other cancers used as controls. A Chronicle investigation reported last year that there is a heated controversy surrounding detection of SV40 and that most U.S. government's studies over the past decade have debunked the theory that SV40 is causing human cancer or even present in tumors.
But The Chronicle found that more than 60 studies from 30 laboratories around the world have reported detections of the virus in human malignancies. Dr. Jay A. Levy, a renowned virologist ``I've been in meetings where people say there is nothing to it,'' said at the University of CalifornPage: 1 2 3 Related medicine news :1
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