Navigation Links
Malfunction of Gene Causes Schizophrenia, Depression

An international team of researchers has confirmed that the malfunction of a gene causes schizophrenia and depression , according to a study published Thursday's issue of the journal Neuron.

The researchers said their findings in mice offer a possible animal model for developing treatments for schizophrenia and depression, which have been proven to share common genetic mechanisms by the researchers.

In their experiments, the researchers sought to explore the consequences of mutating a gene called "Disrupted in schizophrenia 1" (DISC1), which was found to be associated with schizophrenia, bipolar disorder and major depression.

The researchers' theory was that different mutant variations of DISC1 might have different pathological effects.

To test this theory, they screened a large population of mouse mutants to isolate two with different mutations in DISC1.

They found that, indeed, one of the mutant mouse strains exhibited abnormal behavior and memory deficiencies resembling the symptoms of schizophrenia in humans. Additionally, these symptoms could be alleviated in the mice by anti-psychotic drugs.

Similarly, the other mutant mouse strain showed behaviors that reflected depressive symptoms. These symptoms could be alleviated by an antidepressant, the researchers said.

Both types of DISC1 mutant mice exhibited the same kind of reduced brain volume seen in people with schizophrenia and depression, and both types showed biochemical abnormalities in the function of the protein produced by the DISC1 gene.

The researchers concluded that the different effects of anti-psychotic and antidepressant drugs on the two mutant strains "might provide clues to effective medications for these patient groups.

"Indeed, these mice could represent a model system to explore novel treatment and preventative strategies for certain symptoms of major mental illness."
They wrote that "our findings lend further credence to the growing recognition that schizophrenia and bipolar disorder share, at least in part, the common genetic etiologies and thus underlying molecular mechanisms".


'"/>




Related medicine news :

1. Withdrawal Notice Issued For Older Pacemakers Due To Malfunctioning of the Device
2. Scientists Concerned Over Increasing Malfunction Of Heart Devices
3. Small Kidney Malfunctions Can Increase The Risk Of Deaths
4. Malfunction Of Key Growth Factor Increases Mortality Rate From Pulmonary Fibrosis In Blacks
5. American Wins Lawsuit Over Penile Implant Malfunction
6. Malfunction of Gene Causes Schizophrenia, Depression
7. Breast Cancer Surgery Causes Psychological problems
8. Causes of weakness in the aged
9. Gene Mutation Causes Ovarian Failure
10. Studying The Causes Of Autism
11. Heart Drug Also Effective In Preventing Specific Causes Of Death
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Pixel Film ... Pro X. , "Film editors can give their videos a whole new perspective by ... Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over 30 ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... 25, 2016 , ... Experts from the American Institutes for ... Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. , AIR ... care planning, healthcare costs and patient and family engagement. , AIR researchers will ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN FRANCISCO, Calif. , June 24, 2016 ... GBT ), a biopharmaceutical company developing novel therapeutics ... significant unmet needs, today announced the closing of ... shares of common stock, at the public offering ... shares in the offering were offered by GBT. ...
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
Breaking Medicine Technology: