Navigation Links
Malfunction of Gene Causes Schizophrenia, Depression

An international team of researchers has confirmed that the malfunction of a gene causes schizophrenia and depression//, according to a study published Thursday's issue of the journal Neuron.

The researchers said their findings in mice offer a possible animal model for developing treatments for schizophrenia and depression, which have been proven to share common genetic mechanisms by the researchers.

In their experiments, the researchers sought to explore the consequences of mutating a gene called "Disrupted in schizophrenia 1" (DISC1), which was found to be associated with schizophrenia, bipolar disorder and major depression.

The researchers' theory was that different mutant variations of DISC1 might have different pathological effects.

To test this theory, they screened a large population of mouse mutants to isolate two with different mutations in DISC1.

They found that, indeed, one of the mutant mouse strains exhibited abnormal behavior and memory deficiencies resembling the symptoms of schizophrenia in humans. Additionally, these symptoms could be alleviated in the mice by anti-psychotic drugs.

Similarly, the other mutant mouse strain showed behaviors that reflected depressive symptoms. These symptoms could be alleviated by an antidepressant, the researchers said.

Both types of DISC1 mutant mice exhibited the same kind of reduced brain volume seen in people with schizophrenia and depression, and both types showed biochemical abnormalities in the function of the protein produced by the DISC1 gene.

The researchers concluded that the different effects of anti-psychotic and antidepressant drugs on the two mutant strains "might provide clues to effective medications for these patient groups.

"Indeed, these mice could represent a model system to explore novel treatment and preventative strategies for certain symptoms of major mental illness."

They wr
'"/>




Page: 1 2

Related medicine news :

1. Withdrawal Notice Issued For Older Pacemakers Due To Malfunctioning of the Device
2. Scientists Concerned Over Increasing Malfunction Of Heart Devices
3. Small Kidney Malfunctions Can Increase The Risk Of Deaths
4. Malfunction Of Key Growth Factor Increases Mortality Rate From Pulmonary Fibrosis In Blacks
5. American Wins Lawsuit Over Penile Implant Malfunction
6. Breast Cancer Surgery Causes Psychological problems
7. Causes of weakness in the aged
8. Gene Mutation Causes Ovarian Failure
9. Studying The Causes Of Autism
10. Heart Drug Also Effective In Preventing Specific Causes Of Death
11. More Causes of Bladder Cancer Identified
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Malfunction Gene Causes Schizophrenia Depression

(Date:6/3/2015)... (PRWEB) June 03, 2015 VeoMed ... to expand online and mobile access to premier ... and Maintenance of Certification (MOC) activities. ... VeoMed’s innovative courses to Decker’s extensive lists of ... in purchasing access to VeoMed’s premier online and ...
(Date:6/3/2015)... Texas (PRWEB) June 03, 2015 ... and Analytics solutions, today announced the launch of ... EXtensions (DSX) for SAP® BusinessObjects™ Design Studio. The ... additional visualization capabilities and advanced functionalities into their ... the DSX suite, Visual BI is adding key ...
(Date:6/3/2015)... (PRWEB) June 03, 2015 According to ... police officers intercepted fake oxycodone pills which actually ... were doctored to look legitimate, and even sported the ... are warning those consuming 30 mg oxycodone to be ... pills online or buy them illegally on the street. ...
(Date:6/3/2015)... 2015 These are challenging and unpredictable ... growing number of digital-first business are rewriting the rules ... a serious need for traditional businesses to take on ... and deliver their services. On top of this ... and technology start-ups, to bring new innovation and approaches ...
(Date:6/3/2015)... June 03, 2015 Fit Body Boot ... camp fitness program. The company helps thousands of individuals across ... encourage more people to hit the gym and get the ... tips for getting the most out any gym membership: , ... about committing to gym memberships is saying motivated and on ...
Breaking Medicine News(10 mins):Health News:VeoMed and Decker Intellectual Properties, the Owner of Scientific American Medicine, Announce a Partnership to Expand Access to Premier Online CME Courses 2Health News:Visual BI Launches Second Release for its Design Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio 2Health News:Visual BI Launches Second Release for its Design Studio EXtensions (DSX) for SAP® BusinessObjects™ Design Studio 3Health News:Fake Oxycodone Pills of Fentanyl Discovered in Tennessee by Police 2Health News:Fake Oxycodone Pills of Fentanyl Discovered in Tennessee by Police 3Health News:Chief Digital Officer of Travelex joins Bayer, Abellio and Just Eat at The Open Mobile Summit London 2Health News:Summer Body Slim-Down: 5 Ways to Avoid Quitting Gym Memberships this Summer 2Health News:Summer Body Slim-Down: 5 Ways to Avoid Quitting Gym Memberships this Summer 3
... CHICAGO Results of a randomized, controlled clinical trial presented ... North America (RSNA) reveal that one in five patients with ... legs and other parts of the body also have significant ... (PAD) occurs when plaque, a combination of fat, cholesterol and ...
... St. Louis, MO, December 1, 2009 Adolescent obesity is ... every three children, resulting in 4-5 million overweight youth in ... 2009 issue of the Journal of the American Dietetic ... dietary intake and physical activity, comparing overweight adolescents who lost ...
... ... treatments and send patients home pregnant with multiples. While they want to achieve a ... mindful of the burden multiple births can put on a country’s healthcare system. , ... (PRWeb UK) November 30, 2009 -- ...
... , CHICAGO, Dec. 1 Results of a randomized, controlled ... Radiological Society of North America (RSNA) reveal that one in ... blood to the legs and other parts of the body ... Peripheral arterial disease (PAD) occurs when plaque, a combination of ...
... CHICAGO, Dec. 1 High-frequency ultrasound with elastography can ... to a study presented today at the annual meeting ... "High-frequency ultrasound with elastography has the potential to improve ... Eliot L. Siegel, M.D., vice chairman of the Department ...
... , CHICAGO, Dec. 1 A study presented ... North America (RSNA) revealed that MRI is a highly accurate ... common condition that is the leading cause of death for ... to the increase in cesarean sections and other surgeries that ...
Cached Medicine News:Health News:Severe asymptomatic heart disease may accompany narrowing in leg arteries 2Health News:Investigators identify successful weight control strategies for adolescents 2Health News:East Coast Fertility Aims to Build Families One Baby at a Time by Applying Single Embryo Transfers to Donor Egg Program 2Health News:East Coast Fertility Aims to Build Families One Baby at a Time by Applying Single Embryo Transfers to Donor Egg Program 3Health News:Severe Asymptomatic Heart Disease May Accompany Narrowing in Leg Arteries 2Health News:Severe Asymptomatic Heart Disease May Accompany Narrowing in Leg Arteries 3Health News:Special Ultrasound Accurately Identifies Skin Cancer 2Health News:Special Ultrasound Accurately Identifies Skin Cancer 3Health News:MRI Helps Detect Life-Threatening Pregnancy Complication 2Health News:MRI Helps Detect Life-Threatening Pregnancy Complication 3
(Date:6/3/2015)... 3, 2015  Lightlake Therapeutics Inc. ("Lightlake") (OTCQB: ... on its expertise in opioid antagonists, announced today ... treating opioid overdose with intranasal naloxone, has commenced ... (NDA) to the United States Food and Drug ... naloxone, a drug intended to treat opioid overdose. ...
(Date:6/3/2015)... BARBARA, Calif. , June 3, 2015  The ... formal endorsement of a Midwife Kit as a standard ... Kit was developed by Direct Relief in consultation with ... of charge to midwives in developing countries. ... from complications related to their pregnancy or childbirth.  Skilled ...
(Date:6/3/2015)... , June 3, 2015 ... "Interventional Cardiology & Peripheral Vascular Devices Market (Embolic ... Catheters, EVAR Stent Grafts, IVC Filters, Stents, Balloons ... MarketsandMarkets, the Interventional Cardiology and Peripheral Vascular Devices ... by 2019 with a CAGR of 7.4% from ...
Breaking Medicine Technology:Lightlake Therapeutics Inc. Announces Adapt Pharma Limited Commences Rolling NDA Submission To The FDA For Intranasal Naloxone 2Lightlake Therapeutics Inc. Announces Adapt Pharma Limited Commences Rolling NDA Submission To The FDA For Intranasal Naloxone 3A Kit for Every Midwife: International Confederation of Midwives Endorses Direct Relief-Developed Midwife Kit as Global Standard 2A Kit for Every Midwife: International Confederation of Midwives Endorses Direct Relief-Developed Midwife Kit as Global Standard 3A Kit for Every Midwife: International Confederation of Midwives Endorses Direct Relief-Developed Midwife Kit as Global Standard 4The Interventional Cardiology and Peripheral Vascular Devices Market Worth $26.72 Billion by 2019 2The Interventional Cardiology and Peripheral Vascular Devices Market Worth $26.72 Billion by 2019 3The Interventional Cardiology and Peripheral Vascular Devices Market Worth $26.72 Billion by 2019 4
... Used for temporary internal ... to the bladder. Supplied sterile ... one-time use. CAUTION: Periodic evaluation ... Sof-Flex stents must not remain ...
... Used for temporary internal ... to the bladder. Supplied sterile ... one-time use. CAUTION: Periodic evaluation ... Sof-Flex stents must not remain ...
... instrument introduction. The dual knobs allow ... and removed. The maximum diameter of ... introduced should be measured to ensure ... sterile in peel-open packages. Intended for ...
... to provide urethral drainage ... repair. The C-shape allows ... close during postoperative swelling ... maintaining urethral patency. Supplied ...
Medicine Products: