( osis for African-American scleroderma p...)Malfunction Of Key Growth Factor Increases Mortality Rate From Pulmonary Fibrosis In Blacks,Health

osis for African-American scleroderma patients." Until now the only therapy for this very difficult group of diseases was palliative: oxygen to increase the chance of breathing success and/or trying to generally boost the immune system. Neither approach is real therapy, However, "now that we've identified the c-Met malfunction, it gives us a good direction to follow," Bogatkevich said. "It's a promising target that seems to take the same clear track as the disease's population." First step is "we need to find or develop a suitable animal model where PF can be imposed. Also we plan to do polymorphism studies because probably there are some Whites that have differences in the c-Met function due to damage or signaling difficulties and the results could give us some useful clues." She said it's also possible "now that we know what to study, that further work on scleroderma itself will be more productive. It's a little simpler disease, and since PF develops from these diseases in the first place, going upstream in the pathogenesis could yield even more useful results. These future studies on the c-Met receptor functionality definitely will advance out understanding of this range of diseases," Bogatkevich concluded. *Paper presentation: "Antifibrotic effect of hepatocyte growth factor is impaired in lung fibroblasts isolated from African-Americans," APS Physiology Airway Mechanics and Mechanotransduction in the Lung 767.9/board #C684. Research was by Galina Stephanie Bogatkevich, Anna Ludwicka-Bradley, D. Beth Singleton and Richard M. Silver, Department of Medicine, Medical University of South Carolina, Charleston. Contact: Mayer Resnick mresnick@the-aps.org 301-332-4402 301-634-7209 (office, outside EB dates), or Christine Guilfoy 978-290-2400 APS Newsroom April 1- 5 #112 Moscone Center North 415-905-1024 Source: Eurekalert
'"/>




Page: 1 2
Related medicine news :

1. Withdrawal Notice Issued For Older Pacemakers Due To Malfunctioning of the Device
2. Scientists Concerned Over Increasing Malfunction Of Heart Devices
3. Small Kidney Malfunctions Can Increase The Risk Of Deaths
4. American Wins Lawsuit Over Penile Implant Malfunction
5. Malfunction of Gene Causes Schizophrenia, Depression
6. Anti-Cancer Drug Restores Normal Cell Growth
7. Low-dose Growth Hormone (GH) with diet and exercise may help weight loss
8. Human Growth Hormone Found To be Dangerous For Human Use
9. Stem Cells Found To Offer Promise For Hair Growth
10. Fish Found To Improve Fetal Growth
11. Growth Patterns In Childhood Could Predict Breast Cancer Later In Life