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Male Contraception: Discovery Stirring Interest Among Scientists, Drug Developers

a different environment than the other ATP/ADP carriers,” Kim explained. “While mitochondria generate energy through an oxidative process, recent research indicates that the sperm flagella mainly produces and consumes energy through a process called glycolysis.”

According to Kim, finding that SFEC is associated with glycolysis is particularly significant. “This is the first time that such an ATP carrier protein has been linked to glycolysis,” he said. “In experiments where glycolysis was blocked, the sperm barely quivered, showed no progressive motion and were infertile.”

By contrast, prior experiments found that when the oxidative processes in the sperm’s mitochondria are blocked, sperm continue to swim and fertilize eggs.

“Because they will aim at specific proteins like SFEC and target a unique sub-domain on the protein’s surface, future male contraceptive drugs will be known as intelligent spermicides,” Herr explained. “At UVa, we’ve coined a great name for this new drug class, spermistatic.”
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