Navigation Links
Male Contraception: Discovery Stirring Interest Among Scientists, Drug Developers

In a study recently published online by Developmental Biology, members of Dr. John Herr’s laboratory at the University of Virginia Health System report the discovery// of a new protein within a sperm’s tail that could prove a key target for male contraceptive drugs.

“There’s considerable interest in developing new male contraceptives,” said Herr, who heads UVa’s Center for Research in Contraceptive and Reproductive Health. “To support this effort, our team has been searching for proteins that might serve as target sites for small-molecule drugs.”

The newly discovered protein is called sperm flagellar energy carrier (SFEC). It is the fourth in a family of proteins that perform transfer processes to help cells make and use energy. Inside the cell, these proteins operate much like a shuttle bus, binding and exchanging energy-carrying molecules known as ATP and ADP.

The discovery of SFEC has sparked interest among both basic scientists and contraceptive drug developers because of where it is located in the sperm and the kind of energy-making process that occurs there.

“One approach to male contraception is to disable sperm from swimming, and we think SFEC may be able to play a role in that process,” Herr noted.

Dr. Young-Hwan Kim, the UVa researcher who discovered SFEC and led the study, found the new protein in the distal part of the sperm tail, or flagella. This was an unexpected finding because the three previously identified ATP/ADP carrier proteins reside in cell organelles called mitochondria. In sperm, the mitochondria reside in a region called the midpiece.

UVa researchers also found that SFEC has extensions at both ends of its amino acid sequence. Other ATP/ADP carriers do not have these extensions, which may explain why SFEC is able to perform its shuttling function in the distal sperm tail.

“The distal sperm tail does not have mitochondria, which means that SFEC operates in
'"/>




Page: 1 2

Related medicine news :

1. Discovery of bone gene
2. New Discovery May Help Treat Infertility
3. New Discovery to Increase Survival of Breast cancer Patients
4. Discovery of World’s smallest laser
5. Discovery of a built-in fat sensor
6. OHSU Researchers Announce New Discovery
7. Discovery Of New Molecule Could Solve Cancer Spread Mystery
8. Discovery Of Human Skeletons Could Unfold Facts About By-Gone Ages
9. New Discovery Shows That Brain Could repair Itself After Stroke
10. New Sleep Gene Discovery Wakes Up Scientists
11. Discovery of Elevated Amyloid Peptide levels could lead to Alzheimer’s Preventio
Post Your Comments:
(Date:12/25/2014)... California (PRWEB) December 25, 2014 Helen ... home in Woodland Hills, California after an 8 year ... away on Christmas Eve evening in her home in ... aggressive metastatic breast cancer. , As ... over forty years, she pioneered and championed many of ...
(Date:12/25/2014)... By Dennis Thompson ... -- Very sick children with complex chronic illnesses can receive ... a "medical home," with easy access to a team of ... were less likely to become seriously ill and need either ... received treatment at an enhanced medical home clinic at the ...
(Date:12/25/2014)... Among early stage breast cancer patients who undergo chemotherapy ... will eventually develop leukemia as a result of their ... from a review of more than 20,000 breast cancer ... that the risk for developing treatment-related leukemia, though low, ... "The frequency of bone marrow cancers such as leukemia ...
(Date:12/25/2014)... 2014 Thousands of transvaginal mesh lawsuits ... a number of multidistrict litigations currently underway in U.S. ... LLP reports. According to an Order issued on December ... Joint Status Conference in all of the proceedings on ... directed to submit a proposed agenda to the Court ...
(Date:12/25/2014)... December 25, 2014 Residents at ... Community, recently showed their generous spirit by providing ... Catawba County Parenting Network- Grandparents Raising Grandchildren program. ... gathered around the largest Christmas tree on the ... purchased by residents of the Abernethy Village Association ...
Breaking Medicine News(10 mins):Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 2Health News:Coordinated Care Through 'Medical Home' Best for Chronically Ill Kids: Study 3Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 2Health News:Breast Cancer Chemo Tied to Small But Significant Leukemia Risk 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 3Health News:Federal Court Overseeing Thousands of Transvaginal Mesh Lawsuits Set to Convene Joint Status Conference for All Litigations, Bernstein Liebhard LLP Reports 4Health News:Retirement Community Residents Make Impact During Holiday Season 2
... health insurance to around 1.2 million families below the ... Wednesday. ,"We are aware of the health challenges ... have decided to provide health insurance to BPL families, ... the project this year," Kumaraswamy said in Ingalagi village ...
... Alberta scientists seem to have unraveled a chemical correspondent ... finding promises to be a harbinger of novel ways ... of the human body. The project costing $7.5 million ... a maiden attempt at drafting the human 'metabolome', scientists ...
... with weakened immune systems should not eat raw// or undercooked ... Canada. ,“Eat veggies full of vitamins and minerals, ... keep us strong, energetic and healthy” - a usual advice ... especially sprouts, eaten in homes and at restaurants have been ...
... up from their plate full of food, and are seen to ... ,Earlier, the government had stipulated that anybody with ... obesity surgery done, free of cost. This has led to many ... by the government. ,People suffering obesity as well as ...
... review in the current issue of the Cochrane Library journal ... (ED) - Cialis, Levitra and Viagra appear to be safe ... in a family of medications called phosphodiesterase type 5 (PDE-5) ... of ED. Experts have estimated that the diabetic men ...
... band surgery appears to be an effective procedure to combat ... NYU Medical Center. It is the first study to evaluate ... and it revealed that patients on average lost about 50% ... study is published in the January issue of the Journal ...
Cached Medicine News:Health News:Karnataka's Free Health Insurance to the Poor 2Health News:Raw (or) Undercooked Sprouts May Carry Harmful Bacteria 2Health News:ED Drugs - Safe and Effective for Diabetic Men 2Health News:Stomach Banding Surgery Effective for Adolescents 2Health News:Stomach Banding Surgery Effective for Adolescents 3
(Date:12/24/2014)... -- Echo Therapeutics, Inc. (NASDAQ: ECTE ... permeation, continuous glucose monitoring and associated technologies, today ... been appointed Chief Executive Officer effective December 22, ... of experience in the medical device, pharmaceutical and ... Vice President, Business Development, Otsuka Pharmaceuticals as well as ...
(Date:12/24/2014)... Dec. 23, 2014 ResMed (NYSE: RMD ... action against Chinese medical device manufacturer BMC Medical Co., Ltd. ... that BMC,s masks listed below infringe ResMed,s patents, and entered ... masks in the United States : ... mask , Willow nasal pillows mask , iVolve ...
(Date:12/24/2014)... Mass. , Dec. 23, 2014   ... ), a biopharmaceutical company developing therapeutic products for ... Medicines Agency (EMA) of the Marketing Authorization Application ... EMA recently granted the company,s request for accelerated ... EMA,s regulatory review time.   The ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
... 29, 2012   CSL Behring today announced that the ... review its Biologics License Application (BLA) for a human 4-factor ... K-antagonist therapy (i.e., warfarin) in patients with acute major bleeding. ... would be the first agent of its kind available in ...
... ROBLES, Calif., May 29, 2012 Specialty Silicone ... to the medical device community, inaugurated its state-of-the-art ... Designed for greater efficiency, the facility joins all ... roof, complementing existing facilities in Tustin, Calif. and ...
Cached Medicine Technology:CSL Behring Announces FDA Filing of Biologics License Application for 4-Factor PCC for Urgent Reversal of Vitamin K Antagonist Anticoagulant Therapy 2CSL Behring Announces FDA Filing of Biologics License Application for 4-Factor PCC for Urgent Reversal of Vitamin K Antagonist Anticoagulant Therapy 3Specialty Silicone Fabricators Inaugurates New State-of-the-Art Facility in Paso Robles 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: