Navigation Links
Malarial gene ascertained,,

Researchers from UK have identified Australian researchers have identified a gene which allows the malaria parasite, Plasmodium falciparum, to develop imperviousness to antimalarial drugs.Plasmodium,is a single-celled organism which is transmitted to humans via the saliva of a biting mosquito, has historically evaded control efforts by building resistance to virtually all of the drugs used to treat malaria.// It is hoped that the new discovery will lead to a new drug that will specifically combat resistance.

Dr Alan Donald, Head of the research team said the finding has been a long time coming. About twelve years ago we discovered this gene and suggested that it might be involved in drug resistance, but another report from another laboratory said that it was not involved. The mutations are in the gene pfmdr1, which encodes for the protein P-glycoprotein homologue 1 (Pgh1). This protein qualifies the parasitic cell to thrive in higher concentrations of antimalarial drugs by stopping the drugs from accruing within the cell.

The mutation helps confer resistance to the drugs mefloquine, quinine, halofantrine, chloroquine, and artemisinin. If a drug can be developed to inhibit the Pgh1 protein, the old drugs would be more effective. However, Dr Donald says other genes also contribute to imperviousness.

"It's clear that there are other genes involved as well. We're in the process of trying to identify the other genes so that we have all the knowledge and can start thinking about developing drugs on a rational basis."

In the shorter term, the discovery will mean existing drugs can be used more carefully. By conducting a genetic survey of the parasite in a particular region, the sensitivity of that population to different drugs can be determined and the drug most likely to be effective can be prescribed.


'"/>




Page: 1

Related medicine news :

1. Chloroquine and Primaquine combination Malarial drug for resistant parasites.
2. Older Malarial Drugs Vs New Ones
3. Death Toll from Malarial Epidemic Raises To 75
4. Malarial Epidemic In Tripura Takes Its Death Toll To 65
5. Bahama’s Malarial Outbreak Need Contro
6. Infants Malarial Risk Lowered by Preventive Measures
7. Clothes Treated with Insecticide Reduces the Risk of Malarial Infection
8. Malarial Deaths on Rise in Assam
9. Malarial Parasite Hides In Placenta
10. New Compound for Anti-Malarial Prophylaxis
11. Controlling Malarial Transmission Not Easy!
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Those who ... with these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, ... Marne, Michigan, has released tools for healthy coping following a traumatic event. , Trauma ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... People across ... in Genome magazine’s Code Talker Award, an essay contest in which patients and their ... award to be presented at the 2016 National Society of Genetic Counselors (NSGC) Annual ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, ... economy by obtaining investment capital for emerging technology companies. SCP has delivered ... already resulted in more than a million dollars of capital investment for five ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, ... Board will take whatever measures required to build a ... stock which is currently listed on the OTC Markets-pink ... Company Chairman and CEO, "We are seeing an anomaly ... to understand, not only by the Company, but shareholders ...
(Date:6/24/2016)... , June 24, 2016  Global Blood ... biopharmaceutical company developing novel therapeutics for the treatment ... today announced the closing of its previously announced ... stock, at the public offering price of $18.75 ... offering were offered by GBT. GBT estimates net ...
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
Breaking Medicine Technology: