Navigation Links
Malarial gene ascertained,,

Researchers from UK have identified Australian researchers have identified a gene which allows the malaria parasite, Plasmodium falciparum, to develop imperviousness to antimalarial drugs.Plasmodium,is a single-celled organism which is transmitted to humans via the saliva of a biting mosquito, has historically evaded control efforts by building resistance to virtually all of the drugs used to treat malaria.// It is hoped that the new discovery will lead to a new drug that will specifically combat resistance.

Dr Alan Donald, Head of the research team said the finding has been a long time coming. About twelve years ago we discovered this gene and suggested that it might be involved in drug resistance, but another report from another laboratory said that it was not involved. The mutations are in the gene pfmdr1, which encodes for the protein P-glycoprotein homologue 1 (Pgh1). This protein qualifies the parasitic cell to thrive in higher concentrations of antimalarial drugs by stopping the drugs from accruing within the cell.

The mutation helps confer resistance to the drugs mefloquine, quinine, halofantrine, chloroquine, and artemisinin. If a drug can be developed to inhibit the Pgh1 protein, the old drugs would be more effective. However, Dr Donald says other genes also contribute to imperviousness.

"It's clear that there are other genes involved as well. We're in the process of trying to identify the other genes so that we have all the knowledge and can start thinking about developing drugs on a rational basis."

In the shorter term, the discovery will mean existing drugs can be used more carefully. By conducting a genetic survey of the parasite in a particular region, the sensitivity of that population to different drugs can be determined and the drug most likely to be effective can be prescribed.


'"/>




Page: 1

Related medicine news :

1. Chloroquine and Primaquine combination Malarial drug for resistant parasites.
2. Older Malarial Drugs Vs New Ones
3. Death Toll from Malarial Epidemic Raises To 75
4. Malarial Epidemic In Tripura Takes Its Death Toll To 65
5. Bahama’s Malarial Outbreak Need Contro
6. Infants Malarial Risk Lowered by Preventive Measures
7. Clothes Treated with Insecticide Reduces the Risk of Malarial Infection
8. Malarial Deaths on Rise in Assam
9. Malarial Parasite Hides In Placenta
10. New Compound for Anti-Malarial Prophylaxis
11. Controlling Malarial Transmission Not Easy!
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/20/2019)... (PRWEB) , ... March 20, 2019 , ... In the ... day, the staff at Chapel of the Flowers had a very special project that ... the world participated in the annual Walk-For-Wishes for Southern Nevada. , Chapel of ...
(Date:3/20/2019)... ... 2019 , ... EBSCO Health , the leading provider ... the certification of two decision aids by the Washington State Health Care Authority, ... Yes or No? Currently, Washington is the only state requiring certification for shared ...
(Date:3/20/2019)... ... March 20, 2019 , ... ... growth of 41 percent from 2017 to 2018. In total, sales generated for ... “Our sales and marketing teams delivered significant accomplishments and milestones in 2018. In ...
(Date:3/20/2019)... ... ... Nike Softball Camp SUNY Cobleskill will be held at State ... staff. , Coach Slupinski takes the reigns of the SUNY Cobleskill softball program after ... 2 seasons. Slupinski had an impressive playing career for the University of Rochester in ...
(Date:3/20/2019)... ... 20, 2019 , ... The Center for Advancing Innovation (CAI), ... open innovation contest to advance high-impact inventions and solutions to defeat brain tumors. ... will launch 15+ startups to commercialize promising drugs, devices, diagnostics, and digital health ...
Breaking Medicine News(10 mins):
(Date:3/20/2019)... (PRWEB) , ... March 20, 2019 , ... ... presentations for its Health IT + Clinical Leadership + Pharmacy Conference, held May ... ,     Terry Bradshaw, Co-Host and Analyst for Fox NFL Sunday and NFL Legend; ...
(Date:3/20/2019)... , ... March 20, 2019 , ... According to ... have higher rates of eye diseases such as cataract, glaucoma and age-related macular ... changes in vision related to pregnancy and menopause. , Prevent Blindness has designated April ...
(Date:3/20/2019)... , ... March 20, 2019 , ... Nike Volleyball ... be directed by Rick Swan, the head volleyball coach at Colorado College. , This ... means that players from the Rocky Mountain area now have an opportunity to train ...
Breaking Medicine Technology: