Navigation Links
Malarial gene ascertained,,

Researchers from UK have identified Australian researchers have identified a gene which allows the malaria parasite, Plasmodium falciparum, to develop imperviousness to antimalarial drugs.Plasmodium,is a single-celled organism which is transmitted to humans via the saliva of a biting mosquito, has historically evaded control efforts by building resistance to virtually all of the drugs used to treat malaria.// It is hoped that the new discovery will lead to a new drug that will specifically combat resistance.

Dr Alan Donald, Head of the research team said the finding has been a long time coming. About twelve years ago we discovered this gene and suggested that it might be involved in drug resistance, but another report from another laboratory said that it was not involved. The mutations are in the gene pfmdr1, which encodes for the protein P-glycoprotein homologue 1 (Pgh1). This protein qualifies the parasitic cell to thrive in higher concentrations of antimalarial drugs by stopping the drugs from accruing within the cell.

The mutation helps confer resistance to the drugs mefloquine, quinine, halofantrine, chloroquine, and artemisinin. If a drug can be developed to inhibit the Pgh1 protein, the old drugs would be more effective. However, Dr Donald says other genes also contribute to imperviousness.

"It's clear that there are other genes involved as well. We're in the process of trying to identify the other genes so that we have all the knowledge and can start thinking about developing drugs on a rational basis."

In the shorter term, the discovery will mean existing drugs can be used more carefully. By conducting a genetic survey of the parasite in a particular region, the sensitivity of that population to different drugs can be determined and the drug most likely to be effective can be prescribed.


'"/>




Page: 1

Related medicine news :

1. Chloroquine and Primaquine combination Malarial drug for resistant parasites.
2. Older Malarial Drugs Vs New Ones
3. Death Toll from Malarial Epidemic Raises To 75
4. Malarial Epidemic In Tripura Takes Its Death Toll To 65
5. Bahama’s Malarial Outbreak Need Contro
6. Infants Malarial Risk Lowered by Preventive Measures
7. Clothes Treated with Insecticide Reduces the Risk of Malarial Infection
8. Malarial Deaths on Rise in Assam
9. Malarial Parasite Hides In Placenta
10. New Compound for Anti-Malarial Prophylaxis
11. Controlling Malarial Transmission Not Easy!
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland ... iHire in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness ... & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of ...
(Date:6/24/2016)... ... ... June 19, 2016 is World Sickle Cell Observance Day. In an effort to ... treatments, Serenity Recovery Center of Marne, Michigan, has issued a pain management ... (SCD) is a disorder of the red blood cells, which can cause episodes of ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. ... accelerated orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, ... and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB ... Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards ... in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With ...
(Date:6/24/2016)... ... ... National recruitment firm Slone Partners is pleased to announce the placement ... Vice President of North American Capital Sales at HTG Molecular . ... in the commercialization of the HTG EdgeSeq system and associated reagents in North America. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Va. , June 24, 2016 The ... set of recommendations that would allow biopharmaceutical ... (HCEI) with entities that make formulary and coverage decisions, ... the "value" of new medicines. The recommendations ... does not appear on the drug label, a prohibition ...
(Date:6/24/2016)... June 24, 2016 According to ... Type (Standard Pen Needles, Safety Pen Needles), Needle Length ... Growth Hormone), Mode of Purchase (Retail, Non-Retail) - Trends ... report studies the market for the forecast period of ... USD 2.81 Billion by 2021 from USD 1.65 Billion ...
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
Breaking Medicine Technology: