Navigation Links
Malaria’s Invisibility Code Identifie

Research scholars belonging to the Howard Hughes Medical Institute (HHMI) have discovered how the malaria parasite, Plasmodium falciparum is able to turn on its cloaking genes, and pass the human immune system.// Even if the camouflage proteins of the parasite were to be detected by the immune system, the remaining parasites can still escape by switching disguises.

Malaria takes a toll of 2.7 million human lives annually, mostly in Africa. The survival of the parasite is based on its genetic machinery, according to the HHMI research. The gene's promoter which is a DNA sequence initiates the production of its protein, and also keeps under cover the other cloaking genes, according to researchers Brendan Crabb and Alan Cowman. The chief site of action is the promoter, according to them.

The PfEMP1 protein is used by the malaria parasites on the cells which they occupy. The immune system of human beings is evaded by the use of this surface protein. The protein is however incapable of protecting the parasite from immune cells which are on the patrol, making it necessary for the parasite to change its camouflage frequently.

Continuous exposure to malaria is required to gain immunity from it, and by and large children account for the largest number of casualties to the infection. The P. falciparum's 14 chromosomes are where the genes are generally found. The chromosome packaging regulates the var genes, according to the study. The DNA can be encased in chromosomes very securely by certain proteins. The genetic activity takes place at the very edge of the nucleus, wherein the chromosome ends surround the promoter which contain the silenced var genes. The art of cloning big DNA sequences had to be mastered by the scientists for this research.

The parasite’s var genes can be silenced by a promoter. The antigenic variation program has been infiltrated for the first time through this research, and this can also be utilized to find out how immunity from the disease is attained. The var gene machinery is being disassembled by the researchers with the object of identifying the proteins which activate and unpack the promoter region. The final object of the research is to identify new therapies which will counter the immune evasion strategies of the parasite.


'"/>




Related medicine news :

1. The heat is on: Warm up time for Malaria’s clim
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... now treating sleep apnea using cutting-edge Oventus O2Vent technology. As many ... sleep disorder characterized by frequent cessation in breathing. Oral appliances can offer significant ...
(Date:10/12/2017)... , ... October 12, 2017 , ... IsoComforter, Inc. ( ... announced today the introduction of an innovative new design of the shoulder pad. ... you get maximum comfort while controlling your pain while using cold therapy. By utilizing ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the ... to develop to enable prevention of a major side effect of chemotherapy in ... in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
(Date:10/2/2017)... 2017 Halo Labs announces the European launch of their ... HORIZON at MIBio 2017 in Cambridge, U.K ... matter in biopharmaceutical samples with unprecedented speed and sensitivity while using ... Backgrounded Membrane Imaging. ... subvisible particle analysis system ...
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
Breaking Medicine Technology: