Navigation Links
Malaria and HIV Jointly Affects Pregnant Women and Their Infants

A new research has found that HIV and malaria combine to adversely affect pregnant women and their infants.

University of Toronto researchers have exposed the origin by which pregnant women guard themselves against malaria and have also discovered how the HIV virus works to counter this defence. The research could lead to superior vaccines for pregnant women in malaria-ravished regions.

Malaria is a parasitic disease spread by mosquitoes that kills more than one million people every year. While the disease by and large hits children, malaria also brutally affects pregnant women, particularly during their first pregnancy, accounting for a projected 400,000 cases of severe anaemia and 200,000 infant deaths each year.

With the recent awareness that HIV further worsens pregnancy-associated malaria (PAM) there is a pressing need to comprehend these diseases during pregnancy and turn this knowledge into effective therapies.

Until now the mechanisms by which pregnant women defend themselves against malaria and how HIV impairs this defence have been unknown, but a paper published in PLoS Medicine (Public Library of Science) pins down how the virus targets the immune response in pregnant women.

"PAM can be a deadly condition that leaves mothers and their children particularly vulnerable. We set out to understand how women acquire protection against malaria during pregnancy and how HIV infection impairs that protection. By understanding how they lost protection in the face of HIV we learned how they acquired protection against malaria in the first place, says Professor Kevin Kain, an infectious disease specialist and lead author of the study.

PAM occurs when red blood cells infected with malaria parasites congregate in the placenta resulting in harm to both mother and the budding baby. First-time mothers are predominantly prone to PAM whereas women in subsequent pregnancies become protected a gainst PAM. But HIV virus leads to the hammering of protection and makes them as vulnerable as first-time mothers.

To discover how HIV affects PAM, Kain and his team collected samples from women in the first pregnancy as well as from women in their subsequent ones living in the Kenyan region where malaria is widespread. The researchers demonstrated that protection to PAM is arbitrated by a unique type of antibody that allows women to preferentially clear the parasites in their placentas.

The results showed that HIV-infected women lose these antibodies and again become susceptible to the negative effects of PAM.

The findings, according to Kain, may help in the development of superior PAM vaccines.

"This is only the first step in creating therapeutics to treat this devastating disease. We hope to help translate this knowledge into more effective vaccines designed to generate these types of protective antibodies, Kain said.


'"/>




Related medicine news :

1. Malaria strikes Munger tribals
2. Sponging Cattle betters spraying in eradicating Malaria
3. Gene researchers make Malaria-resistant mosquito
4. More Treatment Options For Malaria
5. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
6. Jharkhand reports 13,000 Malaria cases
7. Researchers Discover Protein That Causes Malaria
8. Malarial gene ascertained
9. Artesunate Is Better For Malaria Than Quinine
10. New Strategies For Effective Treatment Of Malaria
11. Chloroquine and Primaquine combination Malarial drug for resistant parasites.
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2017)... ... May 19, 2017 , ... ... announce the appointment of James (Jim) Vertino as Chief Information Officer (CIO). He ... transformational leader who drives innovation and business performance. He defines strategic roadmaps by ...
(Date:5/21/2017)... ... May 20, 2017 , ... Pot. Reefer. Grass. Mary Jane. No ... and share its attributes like never before. More than a map, new social marketplace ... to stores, strains, products – and for the first time – each other. A ...
(Date:5/21/2017)... ... 2017 , ... For more than 20 years United Cutlery has been distinguished ... swords, from functional to fantasy. United Cutlery has always been “Stronger. Sharper” than the ... tradition. , Offering a range of weapons and tools built for battle, the M48 ...
(Date:5/19/2017)... ... May 19, 2017 , ... In a continuous effort ... , a luxury online mattress company that specializes in natural and organic latex mattresses, ... grassroots autism organization) for every unique share their recent viral Facebook video ...
(Date:5/19/2017)... ... 2017 , ... When Kyle Busch graduates from Kansas City University of Medicine ... major research studies that could impact the health of young athletes everywhere. , As ... an orthopedic surgeon, alongside an international team trying to discover why girls involved in ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)... May 18, 2017  Two Bayer U.S. Pharmaceutical leaders ... during its recent 28 th Woman of ... event showcases HBA,s longstanding mission of furthering the advancement ... Cindy Powell-Steffen , senior director of ... division, and Libby Howe , a regional business ...
(Date:5/15/2017)...  Amy Baxter MD, chief executive officer and founder ... relief, was awarded a 2017 Top 40 Healthcare Transformer ... at the MM&M Top 40 Healthcare Transformers dinner and ... on May 10, 2017. The dinner followed a full-day ... the pill."  "Innovation goes beyond invention," noted ...
(Date:5/12/2017)... 2017  The China and Canada joint ... less water, energy and detergent, and features a powerful disinfection process. ... shoebox-sized washing machine that washes and sanitizes women,s panties or babies, ... ... and does not require an external water inlet. ...
Breaking Medicine Technology: