Navigation Links
Major Gene Link Seen to Childhood Asthma

A newly-discovered gene boosts the risk of childhood asthma by as much as 70 percent, according to an investigation into asthma-prone infants in five countries .

The culprit gene, called ORMDL3, is located on Chromosome 17, the paper, published online on Wednesday by the British science journal Nature, says.

Twenty-four experts from Britain, France, Germany, the United States and Austria joined the DNA trawl, comparing samples from 994 children with asthma against those from 1,243 local children who did not have the disease.

Asthmatic youngsters were between 60 and 70 percent likelier to have telltale mutations, called single-nucleotide polymorphisms, in their ORMDL3 gene than healthy counterparts.

"We are confident that we have discovered something new and exciting about childhood asthma," said Miriam Moffatt, from the National Heart and Lung Institute at London's Imperial College.

"These novel findings do not explain completely how asthma is caused, but they do provide a further part of the gene-environment jigsaw that makes up the disease."

In evolutionary terms, ORMDL3 appears to be a very old part of the human genome. Similar genes are found in primitive organisms such as yeast.

It may be a relic of some ancient human immune system, although its precise function -- and the role it appears to play in asthma -- remain unclear, said co-author William Cookson.

Asthma is an inflammation of the bronchial airways that causes the airways to constrict, causing shortness of breath and wheeziness.

The causes are complex, rooted in genetic susceptibility and in an allergic response to so-called environmental factors, such as air pollution, tobacco smoke, stress, strong emotions or exercise.

The disease has surged in prevalence in recent decades, especially in urban areas with poor air quality, and is now the commonest chronic disorder in childhood today. It is controllable, using drugs, but not presently curable.

"(ORMDL3) does not seem to be part of the allergic process," said Cookson. "As its expression is increased in asthmatics, it may be possible to develop therapies against it, but this will take time."


'"/>




Related medicine news :

1. First Artificial Heart patient has Major setback
2. Vision Loss Due To Diabetic Retinopathy a Major Cause Of Concern
3. Depression Found To Be A Major Cause for Death in Elderly
4. Genetics Has A Major Role To Play In Body Shape.
5. Pigs Population A Major Threat To Encephalitis Ravaged UP
6. Delhi Government To Interlink All Major Hospitals Through e-Governance
7. Nine Major Culprits For Tooth Loss Identified By Researchers
8. Obesity Among Children May Become a Major Problem
9. Canadian Lung Cancer Study Lauded As Major Advance in Cancer Fight
10. Smokers Sue Tobacco Major Philip Morris
11. India Can Become Major HIV Drugs Producer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... ... 25, 2016 , ... Dr. Calvin Johnson has dedicated his ... implemented orthobiologic procedures as a method for treating his patients. The procedure is ... to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to help ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... MIAMI, Fla. (PRWEB) , ... June 24, 2016 , ... ... Florida Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this ... of Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this ...
(Date:6/24/2016)... Plano, TX (PRWEB) , ... June 24, 2016 , ... ... taking part in Genome magazine’s Code Talker Award, an essay contest in which patients ... for an award to be presented at the 2016 National Society of Genetic Counselors ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016   Bay Area Lyme Foundation ... Dean Center for Tick Borne Illness , Harvard ... MIT Hacking Medicine, University of California, Berkeley, and ... the five finalists of Lyme Innovation , ... than 100 scientists, clinicians, researchers, entrepreneurs, and investors ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... Research and Markets has announced the addition of the ... to their offering. ... World Market for Companion Diagnostics covers the world market for ... report includes the following: , World IVD ... (N. America, EU, ROW), 2015-2020 , World IVD Companion ...
Breaking Medicine Technology: