Navigation Links
Major Gene Link Seen to Childhood Asthma

A newly-discovered gene boosts the risk of childhood asthma by as much as 70 percent, according to an investigation into asthma-prone infants in five countries .

The culprit gene, called ORMDL3, is located on Chromosome 17, the paper, published online on Wednesday by the British science journal Nature, says.

Twenty-four experts from Britain, France, Germany, the United States and Austria joined the DNA trawl, comparing samples from 994 children with asthma against those from 1,243 local children who did not have the disease.

Asthmatic youngsters were between 60 and 70 percent likelier to have telltale mutations, called single-nucleotide polymorphisms, in their ORMDL3 gene than healthy counterparts.

"We are confident that we have discovered something new and exciting about childhood asthma," said Miriam Moffatt, from the National Heart and Lung Institute at London's Imperial College.

"These novel findings do not explain completely how asthma is caused, but they do provide a further part of the gene-environment jigsaw that makes up the disease."

In evolutionary terms, ORMDL3 appears to be a very old part of the human genome. Similar genes are found in primitive organisms such as yeast.

It may be a relic of some ancient human immune system, although its precise function -- and the role it appears to play in asthma -- remain unclear, said co-author William Cookson.

Asthma is an inflammation of the bronchial airways that causes the airways to constrict, causing shortness of breath and wheeziness.

The causes are complex, rooted in genetic susceptibility and in an allergic response to so-called environmental factors, such as air pollution, tobacco smoke, stress, strong emotions or exercise.

The disease has surged in prevalence in recent decades, especially in urban areas with poor air quality, and is now the commonest chronic disorder in childhood today. It is controllable, using drugs, but not presently curable.

"(ORMDL3) does not seem to be part of the allergic process," said Cookson. "As its expression is increased in asthmatics, it may be possible to develop therapies against it, but this will take time."


Related medicine news :

1. First Artificial Heart patient has Major setback
2. Vision Loss Due To Diabetic Retinopathy a Major Cause Of Concern
3. Depression Found To Be A Major Cause for Death in Elderly
4. Genetics Has A Major Role To Play In Body Shape.
5. Pigs Population A Major Threat To Encephalitis Ravaged UP
6. Delhi Government To Interlink All Major Hospitals Through e-Governance
7. Nine Major Culprits For Tooth Loss Identified By Researchers
8. Obesity Among Children May Become a Major Problem
9. Canadian Lung Cancer Study Lauded As Major Advance in Cancer Fight
10. Smokers Sue Tobacco Major Philip Morris
11. India Can Become Major HIV Drugs Producer
Post Your Comments:

(Date:11/25/2015)... ... November 25, 2015 , ... On November 10, 2015, ... District Court of Connecticut on behalf of a home health care worker who provided ... or former home health care workers employed by Humana, Inc., Humana at Home, Inc., ...
(Date:11/25/2015)... ... 25, 2015 , ... Lakeview Health, a Jacksonville-based drug and ... sobriety and show through pictures what a positive difference it makes. The social ... the hashtag #FacesOfGratitude on their Facebook, Twitter, and Instagram accounts. Short stories ...
(Date:11/25/2015)... Boca Raton, Florida (PRWEB) , ... November 25, ... ... on-site diagnostic testing for physicians and athletic programs, launches new Wimbledon Athletics ... the importance of testing young athletes for unsuspected cardiac abnormalities. About 2,000 people ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... Smiles ... of TMJ Disorder, Bruxism, and moderate facial wrinkling. While many patients are aware of ... of the great success Botox® delivers to those suffering with discomfort, soreness, and pain ...
(Date:11/25/2015)... ... November 25, 2015 , ... Brillianteen, McGaw YMCA’s student-produced musical ... its 65th Anniversary Brillianteen Revue, scheduled for March 4-6, 2016. Auditions for this ... Brillianteen has been a treasured tradition for numerous families in the Evanston community. ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)...  Henry Schein, Inc., the world,s largest provider of ... and animal health practitioners, will unveil at the Greater ... ConnectDental® Pavilion , which brings together for the first ... to help any practice or laboratory enter the digital ... schedule of experts appearing at the Pavilion. --> ...
(Date:11/25/2015)... Nov. 25, 2015 Allergan plc (NYSE: ... and Rugen Therapeutics, a start-up  biotechnology company focused ... CNS disorders and funded by the F-Prime Biomedical ... entered into an exclusive collaboration to support the ... Spectrum Disorders (ASD) and Obsessive Compulsive disorders (OCD). ...
(Date:11/25/2015)... China , Nov. 25, 2015 ... the "Company") (NYSE: MR ), ... of medical devices worldwide, today announced ... annual general meeting of shareholders at ... 11/F, Grand Century, 193 Prince Edward West ...
Breaking Medicine Technology: