Navigation Links
MSU Research Strengthens Link Between Smoking, Pancreatic Cancer

Researchers at Michigan State University have added yet another piece to the puzzle that links cigarette smoking with cancer of the pancreas, one of the deadliest forms of cancer. //

In research published in the recent issue of the International Journal of Cancer, MSU’s James Trosko and colleagues zeroed in on the mechanism by which a healthy cell turns cancerous.

Specifically, they found that the chemicals produced by the burning of tobacco products – polycyclic aromatic hydrocarbons, or PAHs – interfere with communication between the body’s cells. More importantly, the work showed that some of these chemicals don’t necessarily initiate the cancer, but rather contribute to the promotion of it.

“These PAH chemicals are related to the multistage, multimechanism process of carcinogenesis, not by mutating the stem cell, but by triggering the stem cell that’s been previously mutated to proliferate,” said Trosko, a professor of pediatrics and human development. “This finding has major implications, including the possibility that dietary intervention might interrupt or even reverse the promotion of pancreatic cancers.”

Until now, most scientists thought that specific PAHs produced by burning tobacco mutated genes which, in turn, triggered the cancer mechanism.

“We take issue with this interpretation,” Trosko said. “We don’t believe that the PAH chemicals cause mutations which then lead to cancer.”

Pancreatic cancer is one of the more deadly forms of cancer, with an average survival rate of only about a year. It’s projected that more than 37,000 Americans will be diagnosed with pancreatic cancer in 2007.

Trosko noted that PAHs are formed when any substance containing certain proteins is burned, including foods.

“PAHs are all over,” he said. “When you grill a steak or a hamburger, for example, you get exactly the same class of chemicals.”

This research is the culminat ion of nearly 30 years of work in Trosko’s lab. It was in 1979 that Trosko, colleagues and students demonstrated that tumor-promoting chemicals interfered with a cell’s ability to communicate with other cells. Later, this group isolated adult human pancreatic stem cells from human pancreatic tissue.

Subsequent published findings indicated that these stem cells appeared to be targets for cancer.

“Since we had the system here in our lab, we decided to see if PAHs would act as a tumor promoter,” he said. “And sure enough they did.”

The good news is that people who quit smoking can dramatically improve their chances of avoiding cancers.

“If these chemicals act like cancer promoters and not initiators,” Trosko said, “then quitting smoking can assist in interrupting the process.”


Souce-Bio-Bio Technology
SRM
'"/>




Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... 24, 2016 , ... EB Medicine presented its first-ever “Issue ... conference in Ponte Vedra Beach, FL. The awards honor the outstanding work of ... and Pediatric Emergency Medicine Practice. , “With this award, we recognize the ...
(Date:6/24/2016)... Vegas, Nevada (PRWEB) , ... June 24, 2016 ... ... Las Vegas client, The Grove Investment Group (TGIG), has initiated cultivation and processing ... Grove, in Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of ...
(Date:6/24/2016)... ... ... recruitment firm Slone Partners is pleased to announce the placement of Suzanne ... of North American Capital Sales at HTG Molecular . , In ... commercialization of the HTG EdgeSeq system and associated reagents in North America. , Headquartered ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, MTI-GlobalStem, a provider ... and other difficult to transfect cells, announces its launch of the PluriQ™ G9™ ... Editing System is a complete system for culturing and transfecting human pluripotent ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... "The World Market for Companion Diagnostic Tests" report to ... World Market for Companion Diagnostics The World ... diagnostic and personalized medicine diagnostics. Market analysis in the report ... Diagnostics Test Market (In Vitro Diagnostic Kits) by Region (N. ...
Breaking Medicine Technology: