Navigation Links
MRI with nanoparticles highly sensitive in detecting prostate cancer metastases

High-resolution MRI with magnetic nanoparticles is highly sensitive in detecting clinically occult lymph-node metastases in prostate cancer, according to a new report. In fact, routine use of this modality preoperatively could obviate many unneeded surgeries.//
The nanoparticles, which are given intravenously 24 hours before scanning, work by binding to lymphatic cells. The particles only bind to normal cells, so it is the areas that do not "light up" on MRI that are suspicious for malignancy.

MRI with magnetic nanoparticles "is very likely going to change the way cancers can be staged," say senior doctors. "In the study 25% of patients could have avoided surgery if scanning with nanoparticles had been done preoperatively." Currently, there is no way of knowing before surgery which patients will have microscopic tumor spread to the lymph nodes.

The findings, which are published in the June 19th issue of The New England Journal of Medicine, are based on a study of 80 men with prostate cancer who underwent lymph-node resection or biopsy. Prior to surgery, MRI was performed in all patients before and after infusion of nanoparticles. Of the 334 nodes removed, 63 had histologically proven metastases. With standard imaging criteria for malignancy, 45 of these nodes would have been falsely considered disease free.

MRI with nanoparticles correctly identified all of the patients with nodal disease. In addition, on node-by-node analysis, the sensitivity of this modality, at 90.5%, was significantly higher than that of conventional MRI, at 35.4% (p < 0.001). The nanoparticles appear to be very safe and none of the patients experienced any side effects so far.

The team has also tested the agent's ability to detect metastases from lung and breast cancer and it appears to work equally well. "That's the beauty of targeting normal cells rather than focusing on the malignant cells which always mutate ."

The nanoparticl es, which are being developed by Massachusetts-based Advanced Magnetics Inc. under the name Combidex, are in the final stages of approval by the US Food and Drug Administration.
'"/>




Related medicine news :

1. Threat posed by highly resistant strains of TB
2. Female Circumcision highly Prevalent in Mali
3. Sensitive to bright light? You may have sensitive teeth also
4. Some more sensitive to pain
5. Adult stem cells are sensitive to responses from the environment
6. HIV Positive Individuals Say Media Is Insensitive
7. Vitamin B12 can help in detecting cancers
8. New device for detecting artery blockages
9. Associated scan for detecting ovarian cancer spread
10. Tumour marker for detecting early Recurrence of Thyroid cancer may be soon available
11. Measuring disseminated cancer cells in bone marrow - valuable tool for detecting early breast cancer metastasis
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... 2017 , ... The American Board of Family Medicine's (ABFM) Board of Directors ... Officer, succeeding Dr. James C. Puffer upon his retirement. Dr. Newton will serve in ... retirement at the end of 2018. Upon assuming the role of President and CEO ...
(Date:10/13/2017)... , ... October 13, 2017 ... ... of Pharmacy (SOP) alumni Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ... on guideline updates for the primary prevention of cardiovascular diseases during the ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Many families ... However, many long-term care insurance companies have a waiver for care if the client ... elimination period, when the family pays for care, is often waived, so the benefits ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in agile ... a contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise ... use of Agile methodologies in a consistent and high value manner across CMS ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... LAWRENCE, Mass. , Oct. 4, 2017 /PRNewswire/ ... developer of single-use, self-contained, illuminating medical devices, today ... National Health Surveillance Agency (or Agência Nacional ... ®. The first single-use, cordless surgical retractor with ... ONETRAC provides optimal access, illumination and exposure of ...
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
(Date:10/2/2017)... Halo Labs announces the European launch of their new low volume, ... 2017 in Cambridge, U.K on October 4th. ... samples with unprecedented speed and sensitivity while using far less sample ... ... system ...
Breaking Medicine Technology: