Navigation Links
MRI with nanoparticles highly sensitive in detecting prostate cancer metastases

High-resolution MRI with magnetic nanoparticles is highly sensitive in detecting clinically occult lymph-node metastases in prostate cancer, according to a new report. In fact, routine use of this modality preoperatively could obviate many unneeded surgeries.//
The nanoparticles, which are given intravenously 24 hours before scanning, work by binding to lymphatic cells. The particles only bind to normal cells, so it is the areas that do not "light up" on MRI that are suspicious for malignancy.

MRI with magnetic nanoparticles "is very likely going to change the way cancers can be staged," say senior doctors. "In the study 25% of patients could have avoided surgery if scanning with nanoparticles had been done preoperatively." Currently, there is no way of knowing before surgery which patients will have microscopic tumor spread to the lymph nodes.

The findings, which are published in the June 19th issue of The New England Journal of Medicine, are based on a study of 80 men with prostate cancer who underwent lymph-node resection or biopsy. Prior to surgery, MRI was performed in all patients before and after infusion of nanoparticles. Of the 334 nodes removed, 63 had histologically proven metastases. With standard imaging criteria for malignancy, 45 of these nodes would have been falsely considered disease free.

MRI with nanoparticles correctly identified all of the patients with nodal disease. In addition, on node-by-node analysis, the sensitivity of this modality, at 90.5%, was significantly higher than that of conventional MRI, at 35.4% (p < 0.001). The nanoparticles appear to be very safe and none of the patients experienced any side effects so far.

The team has also tested the agent's ability to detect metastases from lung and breast cancer and it appears to work equally well. "That's the beauty of targeting normal cells rather than focusing on the malignant cells which always mutate ."

The nanoparticl es, which are being developed by Massachusetts-based Advanced Magnetics Inc. under the name Combidex, are in the final stages of approval by the US Food and Drug Administration.

Related medicine news :

1. Threat posed by highly resistant strains of TB
2. Female Circumcision highly Prevalent in Mali
3. Sensitive to bright light? You may have sensitive teeth also
4. Some more sensitive to pain
5. Adult stem cells are sensitive to responses from the environment
6. HIV Positive Individuals Say Media Is Insensitive
7. Vitamin B12 can help in detecting cancers
8. New device for detecting artery blockages
9. Associated scan for detecting ovarian cancer spread
10. Tumour marker for detecting early Recurrence of Thyroid cancer may be soon available
11. Measuring disseminated cancer cells in bone marrow - valuable tool for detecting early breast cancer metastasis
Post Your Comments:

(Date:6/27/2016)... ... June 27, 2016 , ... The ... OSHA Training Institute Education Center headquartered in Northern California, has issued an important ... heat at their worksites. Employers with workers exposed to high temperatures should ...
(Date:6/27/2016)... ... ... "FCPX editors can now reveal their media with growing colorful split screen ... - CEO of Pixel Film Studios. , ProSlice Color brings the split screens ... reveal the media of their split screens with growing colorful panels. , ProSlice Color ...
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... today its affiliation with Tennessee Counseling Association. This new relationship allows ... the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... industry today announced its strategic partnership with Connance, a healthcare industry leader ... two companies’ proven, proprietary technology combine to provide health systems, hospitals and ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... cutting edge technology to revolutionize the emergency ambulance transport experience for the millions ... aware of how Uber has disrupted the taxi industry through the use of ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... "Global MEMS Devices Medical Market Analysis 2016 - Forecast to ... The report contains up to date financial ... reliable analysis. Assessment of major trends with potential impact on ... dive analysis of market segmentation which comprises of sub markets, ...
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
(Date:6/23/2016)... 2016  Guerbet announced today that it has been ... Award . One of 12 suppliers to ... its support of Premier members through exceptional local customer ... commitment to lower costs. ... our outstanding customer service from Premier," says Massimo ...
Breaking Medicine Technology: