Navigation Links
MRI Contrast Agent Linked to Complication in Renal Patients

A "mysterious" condition called nephrogenic systemic fibrosis (NSF)— which occurs only in patients with advanced kidney disease—is strongly// related to use of gadolinium dyes for MRI scans, reports a study in the March Clinical Journal of the American Society of Nephrology.

An accompanying editorial identifies specific groups of patients in whom gadolinium exposure should be avoided, at least until more information is available. Meanwhile, another study in the March CJASN reports "remarkable" improvement in an NSF patient treated with a drug called sodium thiosulfate.

Dr. Shawn E. Cowper of Yale University and colleagues designed a study to determine the true risk of NSF among kidney disease patients exposed to gadolinium—an element used in MRI contrast agents such as gadodiamide. "NSF is a newly recognized and sometimes fatal condition in which the skin becomes stiff, sometimes immobilizing the patient. In addition, internal organ involvement may be been," explains Dr. Cowper. "To date, NSF has only occurred in people on dialysis or with impaired renal (kidney) function."

The researchers reviewed records of all patients receiving dialysis in the Bridgeport, Conn., area over an 18-month period. Out of 467 patients, three developed NSF—all three had undergone MRI scans using gadolinium within the previous two months. Another 84 dialysis patients received gadolinium but did not develop NSF.

The overall risk of NSF was estimated at 4.3 cases per 1,000 dialysis patients per year—or about 2.4 percent for each time a patient with advanced kidney disease was exposed to gadolinium. "This means that approximately 1 in 40 gadolinium-based MRI scans resulted in NSF in the renal population," Dr. Cowper adds. There was no risk when MRI scans were done without gadolinium. So far, there have been no reported cases of NSF in patients with intact kidney function.

Dr. Preethi Yerram and colleagues of University of Missouri report on another dialysis patient who developed NSF—and raise hope regarding a possibly effective treatment. The patient developed stiffness, pain, and other symptoms of NSF after undergoing numerous MRI scans with gadolinium. Because of her repeated exposure to gadolinium-based MRI scans, the researchers suspected a "dose-related" effect on NSF risk.

The treatments tried for NSF were of little help. However, the patient's condition improved dramatically after she received sodium thiosulfate, which was given to treat an entirely different problem (calcium deposits in blood vessels). "This is an exciting and very encouraging finding that should prompt further research into the use of STS as a potential treatment for NSF," says Dr Yerram.


Related medicine news :

1. New Multi-Modal Contrast Agents, A Boon For Medical Imaging
2. Lowering Contrast Material Injection in Aged Patients is Cost-effective and can Offset Risks
3. In Elderly Patients Lowering Contrast Material Injection Will Reduce Costs
4. Using Contrast Enhanced Sonography Improves Diagnosis of Liver and Spleen Injuries
5. CT Imaging With Novel Contrast Agent May Predict Heart Attack in Waiting
6. Effective And Economical Agent For Anthrax
7. Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
8. Revelation Of Cancer Agent Could Help In Developing Effective Cancer Drugs
9. Sunitinib a Promising Agent for Treatment of Renal Cell Cancer
10. New Multi-Modal Contrast Agents, A Boon For Medical Imaging
11. Bird Flu May Evolve Into More Transmissible Agent In Humans
Post Your Comments:

(Date:11/26/2015)... ... 2015 , ... Somu Sivaramakrishnan announced today that he joined ... offers travelers, value and care based Travel Services, including exclusive pricing on a ... cabin upgrades and special amenities such as, shore excursions, discounted fares, travel gifts ...
(Date:11/26/2015)... BOSTON, Mass. (PRWEB) , ... November 26, 2015 ... ... a thorough second medical opinion process, participated in the 61st annual Employee Benefits ... Benefit Plans and took place Sunday, November 8th through Wednesday, November 11th, 2015. ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... aggressive than those found on mammography, according to a study published online in ... cancers not seen on mammography may necessitate a change in treatment. , Breast ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... been recognized once again for its stellar workplace culture with the company’s Cincinnati ... , Medical Solutions’ Cincinnati office was named a finalist in Cincinnati Business ...
(Date:11/25/2015)... ... November 25, 2015 , ... On November 10, 2015, Bohrer ... Court of Connecticut on behalf of a home health care worker who provided companionship ... former home health care workers employed by Humana, Inc., Humana at Home, Inc., and ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015  The American ... and Gynecologists (ACOG), and the March of Dimes ... Protecting Our Infants Act of 2015 ... number of newborns born exposed to drugs, such ... the bill,s introduction, all three organizations have worked ...
(Date:11/25/2015)... , Nov. 25, 2015  ARKRAY USA ... continues to provide evidence demonstrating the accuracy of its ... Congress on Insulin Resistance, Diabetes and Cardiovascular Disease in ... both the Company,s GLUCOCARD ® 01 meter and ... accuracy requirements. The ability to accurately measure glucose levels ...
(Date:11/25/2015)... , Nov. 25, 2015  Trovagene, Inc. (NASDAQ: ... announced that Chief Executive Officer Antonius Schuh, Ph.D., is ... th Annual Piper Jaffray Healthcare Conference. ... New York Palace Hotel in New York ... p.m. EST. Mr. Schuh will be available for one-on-one ...
Breaking Medicine Technology: