Navigation Links
MRI Contrast Agent Linked to Complication in Renal Patients

A "mysterious" condition called nephrogenic systemic fibrosis (NSF)— which occurs only in patients with advanced kidney disease—is strongly// related to use of gadolinium dyes for MRI scans, reports a study in the March Clinical Journal of the American Society of Nephrology.

An accompanying editorial identifies specific groups of patients in whom gadolinium exposure should be avoided, at least until more information is available. Meanwhile, another study in the March CJASN reports "remarkable" improvement in an NSF patient treated with a drug called sodium thiosulfate.

Dr. Shawn E. Cowper of Yale University and colleagues designed a study to determine the true risk of NSF among kidney disease patients exposed to gadolinium—an element used in MRI contrast agents such as gadodiamide. "NSF is a newly recognized and sometimes fatal condition in which the skin becomes stiff, sometimes immobilizing the patient. In addition, internal organ involvement may be been," explains Dr. Cowper. "To date, NSF has only occurred in people on dialysis or with impaired renal (kidney) function."

The researchers reviewed records of all patients receiving dialysis in the Bridgeport, Conn., area over an 18-month period. Out of 467 patients, three developed NSF—all three had undergone MRI scans using gadolinium within the previous two months. Another 84 dialysis patients received gadolinium but did not develop NSF.

The overall risk of NSF was estimated at 4.3 cases per 1,000 dialysis patients per year—or about 2.4 percent for each time a patient with advanced kidney disease was exposed to gadolinium. "This means that approximately 1 in 40 gadolinium-based MRI scans resulted in NSF in the renal population," Dr. Cowper adds. There was no risk when MRI scans were done without gadolinium. So far, there have been no reported cases of NSF in patients with intact kidney function.

Dr. Preethi Yerram and colleagues of University of Missouri report on another dialysis patient who developed NSF—and raise hope regarding a possibly effective treatment. The patient developed stiffness, pain, and other symptoms of NSF after undergoing numerous MRI scans with gadolinium. Because of her repeated exposure to gadolinium-based MRI scans, the researchers suspected a "dose-related" effect on NSF risk.

The treatments tried for NSF were of little help. However, the patient's condition improved dramatically after she received sodium thiosulfate, which was given to treat an entirely different problem (calcium deposits in blood vessels). "This is an exciting and very encouraging finding that should prompt further research into the use of STS as a potential treatment for NSF," says Dr Yerram.

Source-NewswiseSRM
'"/>




Related medicine news :

1. New Multi-Modal Contrast Agents, A Boon For Medical Imaging
2. Lowering Contrast Material Injection in Aged Patients is Cost-effective and can Offset Risks
3. In Elderly Patients Lowering Contrast Material Injection Will Reduce Costs
4. Using Contrast Enhanced Sonography Improves Diagnosis of Liver and Spleen Injuries
5. CT Imaging With Novel Contrast Agent May Predict Heart Attack in Waiting
6. Effective And Economical Agent For Anthrax
7. Gold Nanoparticles: Agents For Noninvasive Cancer Therapy
8. Revelation Of Cancer Agent Could Help In Developing Effective Cancer Drugs
9. Sunitinib a Promising Agent for Treatment of Renal Cell Cancer
10. New Multi-Modal Contrast Agents, A Boon For Medical Imaging
11. Bird Flu May Evolve Into More Transmissible Agent In Humans
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/17/2017)... ... ... Livionex, Inc., a Silicon Valley healthcare company focused on treating biofilms and ... gel that shows significant reduction in plaque levels and gum inflammation and bleeding when ... at the Beckman Laser Institute at UC Irvine and has been published in Dentistry, ...
(Date:1/17/2017)... TX (PRWEB) , ... January 17, 2017 , ... ... Texas families from two offices in Tyler, has announced the latest beneficiary of ... Ribbon Wish Network, a nonprofit organization dedicated to fulfilling the dreams of terminally ...
(Date:1/17/2017)... ... January 17, 2017 , ... Today, FloSports , ... announced a new agreement as part of a long-term extension of their media ... includes the airing of some of the sport’s premier events exclusively on FloWrestling.com as ...
(Date:1/16/2017)... ... January 17, 2017 , ... Recently, patients and staff from A ... other volunteers and organizations in support of the annual Binder Park Zoo Halloween celebration ... up in colorful costumes of all designs coming out to enjoy games, face painting, ...
(Date:1/16/2017)... ... January 16, 2017 , ... Etymotic Research, makers of high-fidelity ... electronic earplugs at the NSSF SHOT Show on January 17-20, 2017 at the ... is the shooting, hunting and outdoor trade show and conference for the firearms, ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... Jan. 17, 2017   Anesthesia Business Consultants ... practice management for the anesthesia and pain management ... remains a "clinical conundrum" (as described recently in ... practitioners to think carefully before recommending medical marijuana ... by the National Academies of Sciences, Engineering and ...
(Date:1/17/2017)... N.J. , Jan. 17, 2017 Interpace Diagnostics ... provides clinically useful molecular diagnostic tests and pathology services ... has received a letter dated January 13, 2017 from ... has regained compliance with the requirement of the NASDAQ ... of $1.00 per share. The letter noted ...
(Date:1/17/2017)... 2017  Maureen L. Mulvihill, President and CEO ... 6 senior sales leaders to support the nationwide ... leaders were formerly part of the top producers ... recognized for their performance, they have a proven ... relationships with key customer constituencies. "I have ...
Breaking Medicine Technology: