Navigation Links
MRI Can Monitor Transplanted Islets

Magnetic resonance imaging (MRI) could be a safe way to monitor the fate of transplanted pancreatic islets, says a new study in the September issue of the journal Diabetes. // Researchers from the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) said that they were able to track transplanted islets in mice using the guidelines laid down for human transplants.

"Clinical trials and animal studies show that there is a significant loss of islets following transplantation due to many factors, not just rejection," says Anna Moore, PhD, of the MGH Martinos Center, who led the study. "Currently there is no direct way to follow the causes behind this loss and how it proceeds over time. Monitoring islet survival by noninvasive imaging could give us the ability to detect and measure rates of islet loss under a variety of conditions, which could help develop procedures leading to better therapeutic outcomes."

Pancreatic islet transplants are being investigated as a way to treat or cure patients with type 1 diabetes, in which the insulin-producing islets are attacked by the body's immune system. In an effort to replace destroyed islets and restore normal insulin production and glucose metabolism, several methods of islet transplantation have been developed and tested. One of the most promising – called the Edmonton Protocol, since it was developed at the University of Alberta – is currently the subject of a multicenter clinical trial. In a 2005 report, the Edmonton group noted that, while islet survival is improving, problems continue to exist both with immune rejection and with the initial post-transplantation engraftment of islets. Even in animal studies involving transplants from genetically identical donors, which should not produce immune rejection, as many as 60 percent of islets are lost in soon after the procedure.

In a previously published animal study, the MGH-Martinos group showed that MRI could detect transplanted islets that had been marked with experimental iron-containing nanoparticles. The current study utilized islets labeled with Feridex, an FDA-approved contrast agent, and procedures virtually identical to the Edmonton protocol, in which islets are infused into the recipient's liver. Labeled islets were transplanted into mice with a normal immune system and into mice with a severe genetic immune deficiency that would practically eliminate the rejection process. MR images of the animals' livers were taken seven times over the 14 days after the transplant procedure.

The results verified that that MRI could track the labeled islets over time and reveal how many were surviving. For both groups of mice, the number of islets began to drop immediately after transplantation and reached a plateau at 10 to 14 days. The researchers note that much of the early islet death probably was caused by factors other than rejection, such as damage during the transplant procedure. However, by day 10 the mice with normal immune systems showed a 20 percent greater loss of islets than did the immune-deficient animals – probably the result of rejection – and close examination verified significant immune cell activity in the normal mice.

"Since MRI can provide comprehensive information about the presence and position within the body of entities as small as islets and can be performed repeatedly without subjecting patients to radiation or any invasive procedure, we think it is the most appropriate imaging modality to monitor islet survival," says Moore. "Feridex is an approved imaging agent, so the next logical step could be human clinical trials, although it may be helpful to work on improving the imaging procedures with larger animals first." Moore is an assistant professor of Radiology at Harvard Medical School and director of the Molecular Imaging Laboratory at the Martinos Center.

Source-Eurekalert
AS
'"/>




Related medicine news :

1. Wearable Body Monitoring
2. Testosterone Replacement Therapy Safe If Monitored Appropriately
3. Monitoring Blood Pressure
4. Surgery For Obesity May Need Invasive Monitoring
5. Monitoring Drug Safety
6. Simple Urine Test Can Help To Monitor Disfiguring Birthmarks
7. Drug Prices in India to be Monitored - NPPA to Tie up with ORG
8. Robo-Dog To Monitor Your Calorie Intake
9. New Drug Exubera (Oral Inhaled Insulin) To Be Monitored By Pfizer
10. Medical Gadgets To Monitor Drug Delivery
11. Increased Monitoring By Parents May Result In Lower BMI In Children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/30/2016)... ... May 30, 2016 , ... ... inside of FCPX," said Christina Austin - CEO of Pixel Film Studios. ... within Final Cut Pro X. Choose from abstract transitions to more simple wipes ...
(Date:5/29/2016)... ... , ... Whole Health Supply is happy to announce a new product that ... the public. This is an unusual clipper because it opens to a generous ... about this product is concentrated on ease of use, functionality and durability. It is ...
(Date:5/28/2016)... ... ... and a half of planning the Multiple Pathways of Recovery Conference , CCAR is ... was held May 2 -4, 2016 at the Mystic Marriott Hotel & Spa . ... many pathways individuals use to get into and sustain their recovery. Pathways of recovery ...
(Date:5/27/2016)... ... 2016 , ... W.S. Badger Co. Inc ., the maker of certified ... as one of the best small businesses for new dads by Fatherly, the digital ... businesses providing progressive benefits to new parents on the organization’s 2016 Best Places ...
(Date:5/27/2016)... ... May 27, 2016 , ... ... educate the many who are unaware of the plight of aphasia. In collaboration ... within the “Stroke Awareness” campaign. , The link between stroke and aphasia is ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... As illustrated by the Spring ... the numbers and momentum of cannabis in the US ... billions, more research and development push the sector forward. ... Legal Marijuana Markets Report  from from ArcView Market Research ... the increase in sector is attributed to adult use ...
(Date:5/25/2016)... 25, 2016 Digital Health Dialog, LLC ... by the US Patent and Trademark Office of ... proprietary processes for electronic opt-­in and processing of ... programs, HIPAA compliance and otherwise. Logo - ... "Our technology allows for individuals to ...
(Date:5/25/2016)... 25, 2016 Inivata, a ... of circulating tumour DNA (ctDNA) analysis to improve ... of Professor Clive Morris as Chief ... the clinical development programme, scientific collaborations, and through ... significant improvements in clinical outcomes for patients. ...
Breaking Medicine Technology: