Navigation Links
MIT Biologists Solve Vitamin Puzzle

Solving a mystery that has puzzled scientists for decades, Massachusetts Institute of Technology (MIT) and Harvard researchers have discovered// the final piece of the synthesis pathway of vitamin B12--the only vitamin synthesized exclusively by microorganisms.

B12, the most chemically complex of all vitamins, is essential for human health. Four Nobel Prizes have been awarded for research related to B12, but one fragment of the molecule remained an enigma--until now.

The researchers report that a single enzyme synthesizes the fragment, and they outline a novel reaction mechanism that requires cannibalization of another vitamin.

The work, which has roots in an MIT undergraduate teaching laboratory, 'completes a piece of our understanding of a process very fundamental to life,' said Graham Walker, MIT professor of biology and senior author.

Vitamin B12 is produced by soil microbes that live in symbiotic relationships with plant roots. During the 1980s, an undergraduate research course taught by Walker resulted in a novel method for identifying mutant strains of a soil microbe that could not form a symbiotic relationship with a plant.

Walker's team has now found that one such mutant has a defective form of an enzyme known as BluB that leaves it unable to synthesize B12.

BluB catalyzes the formation of the B12 fragment known as DMB, which joins with another fragment, produced by a separate pathway, to form the vitamin. One of several possible reasons why it took so long to identify BluB is that some bacteria lacking the enzyme can form DMB through an alternate pathway, Walker said.

One of the most unusual aspects of BluB-catalyzed synthesis is its cannibalization of a cofactor derived from another vitamin, B2. During the reaction, the B2 cofactor is split into more than two fragments, one of which becomes DMB.

Normally, the B2-derived cofactor would assist in a reaction by te
'"/>




Page: 1 2 3

Related medicine news :

1. Biologists Trace Cause Of Early Blindness To Tissue Defect
2. Cholesterol Mystery Solved By Nobel Laureates
3. Mystery Of The Placebo Effect, Yet To Be Solved
4. Genetic Therapy Could Solve Parkinson’s Puzzl
5. Dry Earwax Mystery Solved: Ear Wax Gene Identified
6. Double Kidney Transplants to Solve Organ Donor Shortage
7. Gender Question Solved
8. Carp May Solve the Problem Related To Anoxia Related Diseases in Humans
9. Exposure To Solvents May Harm Pregnant Women And Newborns
10. Surgical Intervention to Solve Obesity and Related Problems
11. Discovery Of New Molecule Could Solve Cancer Spread Mystery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: MIT Biologists Solve Vitamin Puzzle

(Date:7/12/2014)... Wright & Schulte LLC has filed a DePuy Pinnacle ... Johnson & Johnson, on behalf of an Ohio man who ... DePuy Pinnacle hip replacement and had to undergo revision surgery ... DePuy hip lawsuit was filed July 7, 2014, in the ... where DePuy Pinnacle Hip lawsuit litigation is underway . ...
(Date:7/12/2014)... Doylestown Hospital recently conducted an interview with Dr. ... Paddock tackles topics including main men's health concerns, ... than men, and testosterone replacement therapy, among others. In ... on Doylestown Hospital’s website, Dr. Brad Paddock says, “A ... you notice pain, bulging, or asymmetry in your lower ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 Utah Valley ... of startups, with awards being bestowed to companies in ... Utah’s outstanding entrepreneur community with recognition for new ideas ... model with incoming revenue. , 25 Under 5 highlights ... state that are under 5 years old. Award recipients ...
(Date:7/12/2014)... 2014 A recent article released by Seattle's ... of suggestions for those seeking cosmetic surgical procedures in ... approaching and the heat begins to enliven the rainy Pacific ... clothing, realizing that they didn’t work out as much during ... cause a sudden surge of people eager to look their ...
(Date:7/12/2014)... (PRWEB) July 12, 2014 Wright & Schulte ... clients in Just For Men Lawsuits (case #59776/2014), announces ... consumers of reports that allege the popular hair dye, Just ... burns to their face, neck and other areas. In addition ... For Men chemical burns , the advertisements being run by ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 5Health News:Ivyland Medical Center’s Dr. Brad Paddock Offers Tips for Men’s Health 2Health News:SquareHook is Recognized for UVEF 25 Businesses Under 5 Years-Watch Out 2Health News:Best Summer Cosmetic Surgeries Revealed in Article By Seattle Plastic Surgeon 2Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 2Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 3Health News:Just for Men Lawsuit News: TV Campaign Launched by Wright & Schulte LLC to Inform Consumers of the Alleged Association between the Popular Hair Dye and Chemical Burns 4
... Interest Group to Enable an Internationally Interoperable ... ... Fla., Feb. 22 Liberty Alliance, the global,identity consortium working ... worldwide, today announced the launch of a,global public forum formed ...
... HIMSS ... - Booth 1835 -, ... excited to announce the continuing growth and maturation,of its Internet-based health ... Health Information Initiative has implemented the,Community MOMENT OF CARE(R) within Miami, ...
... scientists from the University Paris Descartes has solved the ... resistance to multiple types of antibiotics, according to a ... new clues as to how bacteria adapt to resist ... this defense mechanism. , Frdric Dardel and colleagues ...
... concerns about the dangers of kava and the effects ... as the US Food and Drug Administration and Australia,s ... kava and kava products. , Originally from Fiji, ... of Pharmacy at the University of Sydney, Australia, had ...
... of Denver study shows a curriculum-based bullying prevention program reduced ... in the study control group. , Jeffrey M. Jenson and ... of Social Work studied more than 1,100 students in 28 ... exposed to a bullying prevention program called Youth Matters (YM). ...
... their European counterparts, due in part to a higher rate ... in the United States, according to a study presented at ... to European men, U.S. men had 61 percent higher odds ... the odds of stroke as European women. , Most of ...
Cached Medicine News:Health News:Global Interoperability and Patient Privacy Focus of New Liberty Alliance Health Identity Management Group 2Health News:Cogon Systems, Inc. Supports the Formation of Virtual Health Communities with its Community MOMENT OF CARE(R) 2Health News:University of Sydney researchers find new evidence linking kava to liver damage 2Health News:University of Denver bullying victimization study 2Health News:Stroke more prevalent in United States than in Europe 2Health News:Stroke more prevalent in United States than in Europe 3
(Date:7/10/2014)... 10, 2014  The U.S. Department of Health and ... University Hospitals (UH) Case Medical Center Seidman Cancer Center ... aimed at improving care for patients with complex cancer. ... will test a unique model developed at UH to ... significant comorbidities, or demonstrated need for high health care ...
(Date:7/10/2014)... , July 10, 2014 Integrated Silicon ... in advanced memory and analog IC solutions, today announced ... Thursday, July 24, 2014, at 7:00 a.m. Pacific Time ... results for the fiscal 2014 third quarter ended June ... via telephone, dial 1-888-556-4997 before 6:50 a.m. Pacific time ...
(Date:7/10/2014)... 2014 Yesterday, former Congressman Patrick ... manufacturing facility. Rep. Kennedy and Dick Moberg ... cutting-edge research in neurological disease and treatment. ... advocate, Garen Staglin , created One Mind, ... changes that will radically accelerate the development and ...
Breaking Medicine Technology:University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2
... Greenville, SC, announced today that its Glucommander™ 2.0 Enterprise software ... 2 - 17. Glytec,s Glucommander was the first insulin dosing ... it is the only company to achieve specific ... company cleared to offer this technology to hospitals caring for ...
... OLATHE, Kan., May 21, 2012  BD (Becton, Dickinson and ... medical technology company, and Heart to Heart International, a ... their second joint volunteer initiative to strengthen healthcare in ... the world will build upon the progress made by ...
Cached Medicine Technology:Glytec Adds Pediatric Insulin Dosing to its IV and SubQ FDA Clearances 2BD and Heart to Heart International Collaborate on Second Volunteer Service Trip to Help Improve Healthcare in Haiti 2BD and Heart to Heart International Collaborate on Second Volunteer Service Trip to Help Improve Healthcare in Haiti 3
Transcranial vascular DWL doppler....
... powerful automated system capable of handling any ... user-programmable test protocols to begin a fully ... not included in the comprehensive list of ... the Doppler, PVR and PPG instrument modes. ...
Scoliosis Devices....
The CD Horizon Legacy Spinal System is part of the CD Horizon Spinal System designed for use in small stature patients. The posterior implants (hook and screws) are designed to fit patients in the ra...
Medicine Products: