Navigation Links
Lymphocyte/WBC Ratio Helps in Treating ENT Disorders

According to an article in the January issue of Archives of Otolaryngology–Head & Neck Surgery, one of the JAMA/Archives journals, measuring a patient's ratio of white blood cell types may help physicians accurately //distinguish between the similar conditions infectious mononucleosis and bacterial tonsillitis, potentially guiding treatment decisions.

Acute tonsillitis (inflammation of the tonsils) and infectious mononucleosis (caused by the Epstein-Barr virus) are both common ear, nose and throat conditions with similar symptoms, according to background information in the article. These symptoms include sore throat, fever, painful swallowing, white plaque on the tonsils and redness of the throat and tonsils.

'The importance in differentiating patients with tonsillitis from those with glandular fever [mononucleosis] is the prevention of spontaneous rupture of the spleen and acute intra-abdominal hemorrhage,' potential complications of mononucleosis, the authors write. Currently, distinguishing between them requires an expensive mononucleosis spot test.

Dennis M. Wolf, B.Sc., D.O.-H.N.S., M.R.C.S., and colleagues at St. George's Hospital, London, retrospectively analyzed laboratory tests from 120 patients with infectious mononucleosis and 100 patients with bacterial tonsillitis treated at their facility. All patients were given the spot test for mononucleosis and additional blood tests were performed to determine the number of lymphocytes (a particular type of white blood cell involved in the body's immune response) and overall white blood cell count.

Total white blood cell count was significantly increased in the tonsillitis group compared with the mononucleosis group (16,560 cells per microliter vs. 11,400 cells per microliter), but the lymphocyte count was higher in the mononucleosis group (6,490 cells per microliter vs. 1,590 cells per microliter). The ratio of lymphocyte/white blood cell count ratio averaged .54 in the mononucleosis group and .10 in the tonsillitis group.

Based on this data, the researchers determined that a ratio higher than .35 would have a sensitivity of 90 percent and a specificity of 100 percent for the detection of mononucleosis, meaning that an individual with a ratio this high would be correctly diagnosed with mononucleosis 90 percent of the time and an individual with a ratio of .35 or lower would be correctly diagnosed as not having mononucleosis 100 percent of the time. "The specificity and sensitivity of this test seem to be better than the mononucleosis spot test itself," the authors write.

'In conclusion, we recommend that the lymphocyte–white blood cell count ratio should be used as an indicator to decide whether mononucleosis spot tests are required,' they continue. 'Results from our retrospective pilot study suggest that the lymphocyte–white blood cell count ratio could be a quickly available alternative test for the detection of glandular fever [mononucleosis].'



Source-Eurekalert
SI
'"/>




Related medicine news :

1. Minor Improvement In Child Sex Ratio In Haryana
2. Government Takes Tough Stand Against Falling Sex Ratio
3. Imbalance In Gender Ratio Addressed By Religious Leaders
4. Female Ratio Drops Alarmingly In Himachal Due To Feticides
5. Haryana Claims Improvement in Sex Ratio
6. Proper Ratio Of Omega-3 And Omega-6 Could Reduce Prostate Cancer Growth
7. "Active" Brain Makes Rational Decisions!!
8. More is not Merry! Proposal to Ration Embryo to Women having IVF
9. Skewed Sex Ratio! No Problem, We Will Buy Tribes - Says Patel Community In Gujarat
10. Antibiotics Helps Autism
11. Serum Progesterone Helps Stratify Ectopic Pregnancy Risk
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s ... the 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, ...
(Date:10/12/2017)... BALTIMORE (PRWEB) , ... October 12, 2017 , ... ... average of $3,296 in property taxes a year. In some states—like New York, ... higher. , By contrast, many overseas retirement havens have extremely low property-tax rates, ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... , Oct. 12, 2017 AVACEN Medical , ... company with their  2017 New Product Innovation Award for ... extensive primary and secondary medical device market research by Frost ... its first-to-market OTC, drug-free pain relief product, the AVACEN 100, ... to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)...  True Health, a leader in integrated diagnostics ... National Breast Cancer Awareness month to educate doctors ... Research recently published in ... than 10 million American women are at significant ... BRCA2 and have not had testing. These mutations can ...
(Date:10/5/2017)... 5, 2017  In response to the nationwide ... Maxillofacial Surgeons (AAOMS) released prescribing recommendations that urge ... used as a first-line therapy to manage a ... Recognizing the value and importance ... "Opioid Prescribing: Acute and Postoperative Pain Management" stresses ...
Breaking Medicine Technology: