Navigation Links
Lymphocyte/WBC Ratio Helps in Treating ENT Disorders

According to an article in the January issue of Archives of Otolaryngology–Head & Neck Surgery, one of the JAMA/Archives journals, measuring a patient's ratio of white blood cell types may help physicians accurately //distinguish between the similar conditions infectious mononucleosis and bacterial tonsillitis, potentially guiding treatment decisions.

Acute tonsillitis (inflammation of the tonsils) and infectious mononucleosis (caused by the Epstein-Barr virus) are both common ear, nose and throat conditions with similar symptoms, according to background information in the article. These symptoms include sore throat, fever, painful swallowing, white plaque on the tonsils and redness of the throat and tonsils.

'The importance in differentiating patients with tonsillitis from those with glandular fever [mononucleosis] is the prevention of spontaneous rupture of the spleen and acute intra-abdominal hemorrhage,' potential complications of mononucleosis, the authors write. Currently, distinguishing between them requires an expensive mononucleosis spot test.

Dennis M. Wolf, B.Sc., D.O.-H.N.S., M.R.C.S., and colleagues at St. George's Hospital, London, retrospectively analyzed laboratory tests from 120 patients with infectious mononucleosis and 100 patients with bacterial tonsillitis treated at their facility. All patients were given the spot test for mononucleosis and additional blood tests were performed to determine the number of lymphocytes (a particular type of white blood cell involved in the body's immune response) and overall white blood cell count.

Total white blood cell count was significantly increased in the tonsillitis group compared with the mononucleosis group (16,560 cells per microliter vs. 11,400 cells per microliter), but the lymphocyte count was higher in the mononucleosis group (6,490 cells per microliter vs. 1,590 cells per microliter). The ratio of lymphocyte/white blood cell count ratio averaged .54 in the mononucleosis group and .10 in the tonsillitis group.

Based on this data, the researchers determined that a ratio higher than .35 would have a sensitivity of 90 percent and a specificity of 100 percent for the detection of mononucleosis, meaning that an individual with a ratio this high would be correctly diagnosed with mononucleosis 90 percent of the time and an individual with a ratio of .35 or lower would be correctly diagnosed as not having mononucleosis 100 percent of the time. "The specificity and sensitivity of this test seem to be better than the mononucleosis spot test itself," the authors write.

'In conclusion, we recommend that the lymphocyte–white blood cell count ratio should be used as an indicator to decide whether mononucleosis spot tests are required,' they continue. 'Results from our retrospective pilot study suggest that the lymphocyte–white blood cell count ratio could be a quickly available alternative test for the detection of glandular fever [mononucleosis].'



Source-Eurekalert
SI
'"/>




Related medicine news :

1. Minor Improvement In Child Sex Ratio In Haryana
2. Government Takes Tough Stand Against Falling Sex Ratio
3. Imbalance In Gender Ratio Addressed By Religious Leaders
4. Female Ratio Drops Alarmingly In Himachal Due To Feticides
5. Haryana Claims Improvement in Sex Ratio
6. Proper Ratio Of Omega-3 And Omega-6 Could Reduce Prostate Cancer Growth
7. "Active" Brain Makes Rational Decisions!!
8. More is not Merry! Proposal to Ration Embryo to Women having IVF
9. Skewed Sex Ratio! No Problem, We Will Buy Tribes - Says Patel Community In Gujarat
10. Antibiotics Helps Autism
11. Serum Progesterone Helps Stratify Ectopic Pregnancy Risk
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)... , ... May 23, 2017 , ... ... North Carolina have remained steady since 2009, according to a Workers Compensation Research ... The study Monitoring the North Carolina System: CompScope™ Benchmarks, 17th Edition ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... and a 2017 Best in KLAS category winner, has named Daniel P. Bullington ... extend and enhance its technology platform and product offerings,” says Justin Neece, president. ...
(Date:5/23/2017)... ... , ... London, May 23, 2017: Walter Schindler, the Founder and Managing Partner ... Speaker and Contributor to a weeklong series of classes, meetings, field trips and special ... Walter Schindler and SAIL Capital have received an increasing number of ...
(Date:5/23/2017)... ... May 23, 2017 , ... By all indications, and due to months of ... call for diligence, asking homeowners to scout for any open water sources that can ... the annoying buzz of mosquitos is the buzz associated with potential infections stemming from ...
(Date:5/23/2017)... ... May 23, 2017 , ... MedTech For Solutions has announced ... laboratory, to provide hands-on training utilizing cutting-edge equipment at its recently-opened OvaTools Andrology ... MedTech Group Purchasing vendor , will provide specialized equipment to ensure OvaTools participants ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)... May 4, 2017  A new tight-tolerance microextrusion ... other highly-engineered materials, is being launched by Natvar, ... been developed in recent years to service a ... surgical applications. More expensive materials such as glass ... tubing due to their ability to consistently hold ...
(Date:5/3/2017)... 2017  Kalorama Information notes that transplant diagnostics ... year and this is projected to continue to ... (HSCT) or bone marrow transplants require histocompatibility between ... for this task. This according to a new ... The various PCR-based methodologies, Sanger sequencing and NGS ...
(Date:5/2/2017)... and NEW YORK ... As the leading distributor of market intelligence, ... European Med Tech Reimbursement Consulting AB that ... Tech Reimbursement Consulting AB,s proprietary market analyses through the ... professionals around the world easy access to complete product ...
Breaking Medicine Technology: