Navigation Links
Lung cancer molecular profile discovered by researchers.

According to a team of researchers an expression pattern of certain microRNA’s heve been found that can predict tumour aggressiveness in lunch cancer patients.//

The analysis of these findings indicates that miRNAs may represent a new class of diagnostic and prognostic tools for lung cancer.

The Ohio State University Comprehensive Cancer Centre, Columbus, Ohio; the Jikei University School of Medicine, Tokyo, Japan; National Cancer Centre Research Institute, Tokyo, Japan; and the Centre for Cancer Research at the National Cancer Institute (NCI), which is part of the National Institutes of Health have collaborated in the study.

As the name suggests, micro or miRNAs are small segments of genetic material called ribonucleic acid, or RNA, and are thought to control gene ex-pression.

Two miRNAs — has-mir-155 and has-let-7a-2 — have been identified that could be used as prognostic indicators in patients with adenocarcinoma, a malignancy of the mucous glands in the lungs.

A tumour with an overex-pression of has-mir-155 or reduced ex-pression of has-let-7a-2 would indicate the need for aggressive chemotherapy or radiation treatments.

According to Curtis Harris, M.D., chief of the Laboratory of Human Carcinogenesis at NCI and co-leader of this study, “This study is significant because it provides another tool for studying prognosis that is independent of tumour stage. Following surgery, 50 to 60 percent of patients with stage I lung cancer will develop metastatic disease within five years. This may indicate that there are micrometastases that have not been detected by imaging, scanning or pathology. In the future, we can use miRNAs and other biological predictors to select patients who may need more aggressive treatment versus those who may not. Additional studies confirming these results are the next step before incorporating miRNA analysis into routine clinical practice.”

In the study, a total of 104 pairs of primary tumour tissues and corresponding non- cancerous lung tissues were examined. The tumour and corresponding normal tissues were obtained from the same patient to eliminate genetic differences between tumor and normal tissues.

In the words of Carlo Croce, M.D., chair of Molecular Virology, Immunology and Medical Genetics at The Ohio State University and study co-leader, “This is promising research and is the first study to link these miRNAs to lung cancer. We are proposing that has-mir-155 may be acting like an oncogene in lung cancer. Oncogenes control cell growth and, when mutated, can contribute to abnormal cell growth. “miRNAs control the ex-pression of a number of genes so if the miRNA is altered, this could lead to the alteration of a number of genes affecting malignant tumor growth. Although these results are encouraging, further testing is required to demonstrate the validity of using these markers for predicting patient outcomes.”
br>
'"/>




Related medicine news :

1. Vitamin B12 can help in detecting cancers
2. Want skin cancer? Please have a cigarette
3. New hope for cancer victims – will vaccine cure the deadly bug
4. Clintons new problem - Is the outgoing American president suffering from skin cancer?
5. Are cancer patients being taken for a ride?
6. Breast cancer treatment to be determined by gene test
7. Ductal lavage may detect early breast cancer
8. Beware of the oral patch! It could be cancer!!!
9. New drug helps boost cancer treatment
10. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
11. Lose stomach for Life....Preventive removal of stomach saves the risk of cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/5/2016)... , ... May 05, 2016 , ... ... Drago presented a talk highlighting the organization’s successful Care Transitions program ... , The talk was titled “Minimizing Costs in the Post-Acute Environment Through Effective ...
(Date:5/5/2016)... CA (PRWEB) , ... May 05, 2016 , ... The ... the Year, Derek Pittman, along with his university coaching staff. Together they bring their ... with separate sessions run for youth players ages 5-13, and high school players. Session ...
(Date:5/5/2016)... (NEW YORK, New York) , ... (PRWEB) May 05, 2016 , ... ... partnership with healthcare talent acquisition startup, HireNurses, on the eve of National Nurses ... for job seeking nurses and healthcare employers. With their enrollment into the Talent Tech ...
(Date:5/5/2016)... ... 05, 2016 , ... United Collection Bureau, Inc. (UCB) announces Sarah Clark as ... years of experience within the healthcare revenue cycle industry. With a primary focus of ... Patient Financial Services at Spectrum Health. While at Spectrum Health, Clark helped Spectrum achieve ...
(Date:5/5/2016)... ... ... Institute will celebrate its three-year anniversary on May 14 by giving away a free ... May. To date, the Lung Institute has treated over 2,000 people at their five clinics ... the success of this treatment and to the patients who refuse to give up,” says ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Yissum Research Development Company ... that it had signed an exclusive world-wide licensing and ... novel protein degradation and immunomodulatory drugs for cancer and ... candidates representing first-in-class therapy for hematologic and solid malignancies. ... The novel technology was developed by Yinon ...
(Date:5/4/2016)... , May 4, 2016 ... of the  "Global Acute Ischemic Stroke Market ... to their offering.       (Logo: ... Global Acute Ischemic Stroke Market and Competitive ... Acute Ischemic Stroke pipeline products, Acute Ischemic ...
(Date:5/3/2016)... Global Insulin Needles Industry ... key companies and supported with 272 tables and ... on the current state of the Insulin Needles ... including definitions, classifications, applications and industry chain structure. ... the international market including development history, competitive landscape ...
Breaking Medicine Technology: