Navigation Links
Lung cancer molecular profile discovered by researchers.

According to a team of researchers an expression pattern of certain microRNA’s heve been found that can predict tumour aggressiveness in lunch cancer patients.//

The analysis of these findings indicates that miRNAs may represent a new class of diagnostic and prognostic tools for lung cancer.

The Ohio State University Comprehensive Cancer Centre, Columbus, Ohio; the Jikei University School of Medicine, Tokyo, Japan; National Cancer Centre Research Institute, Tokyo, Japan; and the Centre for Cancer Research at the National Cancer Institute (NCI), which is part of the National Institutes of Health have collaborated in the study.

As the name suggests, micro or miRNAs are small segments of genetic material called ribonucleic acid, or RNA, and are thought to control gene ex-pression.

Two miRNAs — has-mir-155 and has-let-7a-2 — have been identified that could be used as prognostic indicators in patients with adenocarcinoma, a malignancy of the mucous glands in the lungs.

A tumour with an overex-pression of has-mir-155 or reduced ex-pression of has-let-7a-2 would indicate the need for aggressive chemotherapy or radiation treatments.

According to Curtis Harris, M.D., chief of the Laboratory of Human Carcinogenesis at NCI and co-leader of this study, “This study is significant because it provides another tool for studying prognosis that is independent of tumour stage. Following surgery, 50 to 60 percent of patients with stage I lung cancer will develop metastatic disease within five years. This may indicate that there are micrometastases that have not been detected by imaging, scanning or pathology. In the future, we can use miRNAs and other biological predictors to select patients who may need more aggressive treatment versus those who may not. Additional studies confirming these results are the next step before incorporating miRNA analysis into routine clinical practice.”

In the study, a total of 104 pairs of primary tumour tissues and corresponding non- cancerous lung tissues were examined. The tumour and corresponding normal tissues were obtained from the same patient to eliminate genetic differences between tumor and normal tissues.

In the words of Carlo Croce, M.D., chair of Molecular Virology, Immunology and Medical Genetics at The Ohio State University and study co-leader, “This is promising research and is the first study to link these miRNAs to lung cancer. We are proposing that has-mir-155 may be acting like an oncogene in lung cancer. Oncogenes control cell growth and, when mutated, can contribute to abnormal cell growth. “miRNAs control the ex-pression of a number of genes so if the miRNA is altered, this could lead to the alteration of a number of genes affecting malignant tumor growth. Although these results are encouraging, further testing is required to demonstrate the validity of using these markers for predicting patient outcomes.”
br>
'"/>




Related medicine news :

1. Vitamin B12 can help in detecting cancers
2. Want skin cancer? Please have a cigarette
3. New hope for cancer victims – will vaccine cure the deadly bug
4. Clintons new problem - Is the outgoing American president suffering from skin cancer?
5. Are cancer patients being taken for a ride?
6. Breast cancer treatment to be determined by gene test
7. Ductal lavage may detect early breast cancer
8. Beware of the oral patch! It could be cancer!!!
9. New drug helps boost cancer treatment
10. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
11. Lose stomach for Life....Preventive removal of stomach saves the risk of cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/16/2017)... ... 16, 2017 , ... Date aired: January 9, 2017 , ... Kleyne, America’s leading water educator, researcher and advocate welcomed health activist, author, science ... Kleyne Hour Power of Water, Global Climate Change and Your Health on Voice ...
(Date:1/16/2017)... , ... January 16, 2017 , ... One thing common ... to treat, but to test for, as well. The money spent screening for and ... Doctors in the U.S. screen patients for cancer more than in any other country ...
(Date:1/16/2017)... WA (PRWEB) , ... January 16, 2017 , ... NexTec ... 2016, a group of 100 organizations honored for their accomplishments in the field of ... such growth, industry leadership and recognition, and innovation. Selection is not based on revenue ...
(Date:1/15/2017)... , ... January 15, 2017 , ... Whole Health Supply, LLC is announcing the release ... are also new avenues for purchase. , The 2017 edition has wide jaws that ... for the older boomers as well as diabetics. This handle is reinforced for extra strength ...
(Date:1/15/2017)... ... January 15, 2017 , ... ... physicians in eight Bay Area counties for 2017. Almost 1,000 nominations were submitted ... managing the award process. Results were announced the magazine’s January 2017 issue ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... , January 13, 2017 On ... Jones Industrial Average, and the S&P 500 edged lower ... ended Thursday,s trading session in bearish territories. Taking into ... Services equities this morning: Myriad Genetics Inc. (NASDAQ: ... ), INC Research Holdings Inc. (NASDAQ: INCR ...
(Date:1/13/2017)... NEW YORK , Jan. 12, 2017 /PRNewswire-USNewswire/ ... type 1 diabetes (T1D) research, is pleased to ... advocacy efforts, the Centers for Medicare & Medicaid ... devices approved by the FDA for use in ... a significant step toward making them eligible for ...
(Date:1/13/2017)... YORK , Jan. 12, 2017  Rosen Law ... filing of a class action lawsuit on behalf of ... ALXN ) from February 10, 2014 through November 9, ... recover damages for Alexion investors under the federal securities ... go to http://rosenlegal.com/cases-991.html or call Phillip ...
Breaking Medicine Technology: