Navigation Links
Lung cancer molecular profile discovered by researchers.

According to a team of researchers an expression pattern of certain microRNA’s heve been found that can predict tumour aggressiveness in lunch cancer patients.//

The analysis of these findings indicates that miRNAs may represent a new class of diagnostic and prognostic tools for lung cancer.

The Ohio State University Comprehensive Cancer Centre, Columbus, Ohio; the Jikei University School of Medicine, Tokyo, Japan; National Cancer Centre Research Institute, Tokyo, Japan; and the Centre for Cancer Research at the National Cancer Institute (NCI), which is part of the National Institutes of Health have collaborated in the study.

As the name suggests, micro or miRNAs are small segments of genetic material called ribonucleic acid, or RNA, and are thought to control gene ex-pression.

Two miRNAs — has-mir-155 and has-let-7a-2 — have been identified that could be used as prognostic indicators in patients with adenocarcinoma, a malignancy of the mucous glands in the lungs.

A tumour with an overex-pression of has-mir-155 or reduced ex-pression of has-let-7a-2 would indicate the need for aggressive chemotherapy or radiation treatments.

According to Curtis Harris, M.D., chief of the Laboratory of Human Carcinogenesis at NCI and co-leader of this study, “This study is significant because it provides another tool for studying prognosis that is independent of tumour stage. Following surgery, 50 to 60 percent of patients with stage I lung cancer will develop metastatic disease within five years. This may indicate that there are micrometastases that have not been detected by imaging, scanning or pathology. In the future, we can use miRNAs and other biological predictors to select patients who may need more aggressive treatment versus those who may not. Additional studies confirming these results are the next step before incorporating miRNA analysis into routine clinical practice.”

In the study, a total of 104 pairs of primary tumour tissues and corresponding non- cancerous lung tissues were examined. The tumour and corresponding normal tissues were obtained from the same patient to eliminate genetic differences between tumor and normal tissues.

In the words of Carlo Croce, M.D., chair of Molecular Virology, Immunology and Medical Genetics at The Ohio State University and study co-leader, “This is promising research and is the first study to link these miRNAs to lung cancer. We are proposing that has-mir-155 may be acting like an oncogene in lung cancer. Oncogenes control cell growth and, when mutated, can contribute to abnormal cell growth. “miRNAs control the ex-pression of a number of genes so if the miRNA is altered, this could lead to the alteration of a number of genes affecting malignant tumor growth. Although these results are encouraging, further testing is required to demonstrate the validity of using these markers for predicting patient outcomes.”

Related medicine news :

1. Vitamin B12 can help in detecting cancers
2. Want skin cancer? Please have a cigarette
3. New hope for cancer victims – will vaccine cure the deadly bug
4. Clintons new problem - Is the outgoing American president suffering from skin cancer?
5. Are cancer patients being taken for a ride?
6. Breast cancer treatment to be determined by gene test
7. Ductal lavage may detect early breast cancer
8. Beware of the oral patch! It could be cancer!!!
9. New drug helps boost cancer treatment
10. Antidepressants come in handy for patients on treatment for hepatitis, cancers and multiple sclerosis
11. Lose stomach for Life....Preventive removal of stomach saves the risk of cancer
Post Your Comments:

(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, ... Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms ... Final Cut Pro X . Simply select a ProHand generator and drag it above ...
(Date:6/25/2016)... ... 25, 2016 , ... Dr. Calvin Johnson has dedicated his ... implemented orthobiologic procedures as a method for treating his patients. The procedure is ... to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to help ...
(Date:6/24/2016)... , ... June 24, 2016 , ... A recent ... most people are unfamiliar with. The article goes on to state that individuals are ... many of these less common operations such as calf and cheek reduction. The Los ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
Breaking Medicine Technology: