Navigation Links
Lowering Risk of Breast Cancer Recurrence

A new class of drugs could reduce the risk of breast cancer recurrence in post-menopausal women. Exemestane is a third-generation aromatase inhibitor. Aromatase inhibitors are drugs that block the conversion of precursor molecules. In the case of breast cancer, aromatase inhibitors block the conversion of precursor molecules into various types of estrogenic compounds. //In a new study, coordinated through the National Surgical Adjuvant Breast and Bowel Project, researchers are studying exemestane to determine if it can further reduce the risk of breast cancer recurrence among post-menopausal women.

John Cole, M.D., from the Ochsner Clinic in New Orleans, explains the ovaries in post-menopausal women no longer make estrogen. However, estrogen is still produced from the adrenal glands and from fatty tissues. He says by using an aromatase inhibitor like exemestane, that small residual amount of estrogen is even further reduced. Dr. Cole says, "You're taking low estrogen and you're making it even lower. Now, why does that matter? Well, breast cancer cells that are hormone-sensitive can sense even those very small amounts of estrogen."

Patients are still being enrolled in the trial. Researchers across the country will enroll 3,000 postmenopausal women who have received at least five years of tamoxifen therapy. Dr. Cole says, "Tamoxifen is a different type of medication. It blocks the receptors for estrogens on cancer cells." He says previous studies show aromatase inhibitors are at least equivalent, if not superior, to tamoxifen. He says, "It seems as though lowering the estrogen levels is even more effective than blocking estrogen interaction with cells in post-menopausal patients."

Dr. Cole says, even after five years of cancer-free status, there still is an ongoing risk of breast cancer recurrence. He says about 20 percent of patients in some groups will have recurrences after five years. He tells Ivanhoe that this is the first trial of thi s kind in this setting but says the results in terms of effectiveness are years away. "It will take a while before there is enough follow-up to be able to have enough recurrences to make a statement." He is optimistic about the efficacy of exemestane and says, "Our goal is to increase the number of patients who are cured from breast cancer by preventing a recurrence. Anything that prevents recurrences is going to increase cure."
'"/>




Related medicine news :

1. Lowering blood pressure beneficial for PAD patients
2. Multi-Drug Therapy Effective in Lowering Blood Pressure
3. Multi-Drug Therapy Found To Be More Effective in Lowering B.P
4. Almonds found To Be Effective In Lowering Cholesterol
5. Almonds As Effective As Certain Drugs In Lowering Cholesterol
6. Using Cholesterol Lowering Drugs Effectively
7. Lowering cholesterol with vegetables in your diet
8. Fibre Rich Food A Boon For Lowering Cholesterol
9. Dark Chocolate Is Helpful In Lowering Blood Pressure.
10. Plant – based Foods More Effective In Lowering Cholesterol
11. Plant – based Foods More Effective In Lowering Cholestero
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... , ... June 26, 2016 , ... On June 10-11, ... of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, MI, ... the city’s history as home to some of the world’s leading providers of cereal ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts ... applications at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention ... health care topics including advance care planning, healthcare costs and patient and family ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... June 24, 2016   Bay Area Lyme ... Dean Center for Tick Borne Illness , ... Rehabilitation, MIT Hacking Medicine, University of California, Berkeley, ... announced the five finalists of Lyme Innovation ... More than 100 scientists, clinicians, researchers, entrepreneurs, and ...
(Date:6/24/2016)... 24, 2016 Research and ... "Structural Electronics 2015-2025: Applications, Technologies, Forecasts" report ... In-Mold Electronics, Smart Skin, Structural Health Monitoring, ... Structural electronics involves electronic and/or electrical components ... replacing dumb structures such as vehicle bodies or ...
Breaking Medicine Technology: