Navigation Links
Lowering Risk of Breast Cancer Recurrence

A new class of drugs could reduce the risk of breast cancer recurrence in post-menopausal women. Exemestane is a third-generation aromatase inhibitor. Aromatase inhibitors are drugs that block the conversion of precursor molecules. In the case of breast cancer, aromatase inhibitors block the conversion of precursor molecules into various types of estrogenic compounds. //In a new study, coordinated through the National Surgical Adjuvant Breast and Bowel Project, researchers are studying exemestane to determine if it can further reduce the risk of breast cancer recurrence among post-menopausal women.

John Cole, M.D., from the Ochsner Clinic in New Orleans, explains the ovaries in post-menopausal women no longer make estrogen. However, estrogen is still produced from the adrenal glands and from fatty tissues. He says by using an aromatase inhibitor like exemestane, that small residual amount of estrogen is even further reduced. Dr. Cole says, "You're taking low estrogen and you're making it even lower. Now, why does that matter? Well, breast cancer cells that are hormone-sensitive can sense even those very small amounts of estrogen."

Patients are still being enrolled in the trial. Researchers across the country will enroll 3,000 postmenopausal women who have received at least five years of tamoxifen therapy. Dr. Cole says, "Tamoxifen is a different type of medication. It blocks the receptors for estrogens on cancer cells." He says previous studies show aromatase inhibitors are at least equivalent, if not superior, to tamoxifen. He says, "It seems as though lowering the estrogen levels is even more effective than blocking estrogen interaction with cells in post-menopausal patients."

Dr. Cole says, even after five years of cancer-free status, there still is an ongoing risk of breast cancer recurrence. He says about 20 percent of patients in some groups will have recurrences after five years. He tells Ivanhoe that this is the first trial of thi s kind in this setting but says the results in terms of effectiveness are years away. "It will take a while before there is enough follow-up to be able to have enough recurrences to make a statement." He is optimistic about the efficacy of exemestane and says, "Our goal is to increase the number of patients who are cured from breast cancer by preventing a recurrence. Anything that prevents recurrences is going to increase cure."
'"/>




Related medicine news :

1. Lowering blood pressure beneficial for PAD patients
2. Multi-Drug Therapy Effective in Lowering Blood Pressure
3. Multi-Drug Therapy Found To Be More Effective in Lowering B.P
4. Almonds found To Be Effective In Lowering Cholesterol
5. Almonds As Effective As Certain Drugs In Lowering Cholesterol
6. Using Cholesterol Lowering Drugs Effectively
7. Lowering cholesterol with vegetables in your diet
8. Fibre Rich Food A Boon For Lowering Cholesterol
9. Dark Chocolate Is Helpful In Lowering Blood Pressure.
10. Plant – based Foods More Effective In Lowering Cholesterol
11. Plant – based Foods More Effective In Lowering Cholestero
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/27/2016)... ... May 27, 2016 , ... Aimed at nurses and employees ... which come courtesy of leaders in the nursing and health care industry. It also ... and associations—namely Abilene Christian University. , As the nursing industry is coming out ...
(Date:5/26/2016)... ... ... Despite last week’s media reports hinting at a June rate hike after the Federal ... an interest rate increase, according to Rajeev Dhawan of the Economic Forecasting Center at ... Committee (FOMC) dot charts are of interest to the press for their noise potential,” ...
(Date:5/26/2016)... California (PRWEB) , ... May 26, 2016 , ... ... associated with discovery of thousands of defective respirators, according to court documents and ... the case of William and Becky Tyler v. American Optical Corporation, Case No. ...
(Date:5/26/2016)... ... May 26, 2016 , ... Connor Sports, through its ... partner for the Tamika Catchings Legacy Tour that will commemorate the Indiana ... hardwood basketball surfaces in all forms and levels of the game, Connor Sports has ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... a significant negative impact on long-term patient survival, reports a team of UPMC ... online this week in the Journal of Thoracic and Cardiovascular Surgery, provide critical ...
Breaking Medicine News(10 mins):
(Date:5/25/2016)... India , May 25, 2016 ... Animation Market by Type (3D, 2D, 4D), by Therapeutic ... Education), by End User (Medical Device Manufacturers, Hospitals/ Clinics) ... studies the global Medical Animation Market for the forecast ... to reach USD 301.3 Million by 2021 from USD ...
(Date:5/25/2016)... and GERMANTOWN, Maryland , May ... QGEN ; Frankfurt Prime Standard: QIA) today announced that ... with Therawis Diagnostics GmbH to develop and commercialize predictive assays ... market PITX2 as a marker to predict effectiveness of anthracycline ... "We are pleased to partner with Therawis, which ...
(Date:5/25/2016)... -- According to Kalorama Information, the world market for ... these are challenging times in the market, there ... companies that remain optimistic and seek innovation.  Toward ... medical device companies spend a higher percentage of ... do companies in other industries.  Also, in addition ...
Breaking Medicine Technology: