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Low LDL Levels Lead to Parkinson's Disease

results are too preliminary, she said. Further large prospective studies are needed, Huang added.

"Parkinson's is a disease full of paradoxes," Huang said. "We've known for years that smoking reduces the risk of developing Parkinson's. More than 40 studies have documented that fact. But we don't advise people to smoke because of the other more serious health risks," she said.

Huang and her colleagues recruited 124 Parkinson's patients who were treated at the UNC Movement Disorder Clinic between July 2002 and November 2004 to take part in the study. Another 112 people, all spouses of patients treated in the clinic, were recruited as the control group. Fasting cholesterol profiles were obtained from each participant. The researchers also recorded information on each participant's gender, age, smoking habits and use of cholesterol-lowering drugs.

Huang notes that the study also found participants with Parkinson's were much less likely to take cholesterol-lowering drugs than participants in the control group. This, combined with the findings about LDL cholesterol, suggests two questions for additional study, Huang said.

"One is whether lower cholesterol predates the onset of Parkinson's. Number two, what is the role of statins in that? In other words, does taking cholesterol-lowering drugs somehow protect against Parkinson's? We need to address these questions," she said.

Source-Eurekalert
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