Navigation Links
Loss of Stem Cells Correlates With Premature Aging

Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the bodys response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans.

The reason these mice age prematurely is that were exhausting their ability to renew tissues, said Eric J. Brown, PhD, Assistant Professor of Cancer Biology. These findings may be helpful to the aging and oncology fields since premature aging syndromes and many cancers involve the loss of DNA repair genes.

When the researchers deleted ATR in the tissues of adult mice, they noticed that the mice showed signs of premature aging, such as hair graying, hair loss, and osteoporosis, within three to four months.

To be able to renew itself, most tissues have a reservoir of specific adult stem cells. These stem cells dont divide as frequently as other cell types since they need to maintain the integrity of their DNA, and multiple divisions lead to natural breaks in DNA. But when these stem cells are needed, their progeny can rapidly divide and are able to replenish the tissue with new cells.

Brown explains that in the current study the mouse cells without ATR had an overwhelming amount of DNA damage and could not contribute to tissue renewal; nevertheless, the 10 to 20 percent of cells that escaped ATR deletion were able to reconstitute tissues in the engineered mice, at least initially. However, it appears that in the long run, even these cells were insufficient to maintain tissue integrity.

Think of aging as a slow loss of stem cells, a deterioration of pools of cells that reside in each tissue type, says Brown. We accelerated the aging process by wiping out a large fraction of these cells pr
'"/>




Page: 1 2

Related medicine news :

1. Blood Cells Capable of Regenerating Liver
2. White Cells Count Can Predict Heart Attack Death Risk
3. Gene Therapy Destroys Pancreatic Cancer Cells
4. Stem Cells Have Few Mutations
5. Heart may pull Cells from Body to Self-repair
6. Cells critical for asthma development found
7. Vitamin D Wipes out Cancer Cells
8. Bone Marrow Cells Help Heart Attack Patients
9. Islet Cells May Lead to Diabetes CureChildren
10. Stem Cells Found To Offer Promise For Hair Growth
11. Bone Marrow Cells Could Yield A New Lease of Life
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Loss Stem Cells Correlates With Premature Aging

(Date:8/31/2014)... (PRWEB) August 31, 2014 1Heart Caregiver ... Clarito and brain fitness expert Tee Barr conducted a ... Ventura City. Activities Director Virginia Ayala and Social Services ... and patients attend this brain fitness session. , Research ... and slowing down the development of dementia and memory ...
(Date:8/31/2014)... Asked to offer tips for ... and "absorption," Dr. Priya Khan, Director of Research ... "Bioavailability" and "absorption" are possibly the most ... industry, second perhaps only to the confusion over ... while related, are not the same. Bioavailability refers ...
(Date:8/31/2014)... a reliable review website, has recently compared many professional ... Hostgator are the best ASP.NET hosting suppliers of August ... the world, but good suppliers are not too many. ... server than running a Linux server, because it needs ... Arvixe and Hostgator are the most outstanding suppliers when ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 Ticket Down ... Bolivia tickets at Dick’s Sporting Goods Park in suburban ... a plethora of games against other international teams on USA ... Cup, Mexico brought a new soccer coach aboard, Miguel Herrera, ... In the build-up before the World Cup in Brazil, the ...
(Date:8/31/2014)... Orem, UT (PRWEB) August 31, 2014 ... C supplement, sourced from organic fruits and ... (requires subscription) in all aspects tested, including purity ... Vitamin C supplements feature Ascorbic Acid from genetically ... an entirely synthetic process. The process involves the ...
Breaking Medicine News(10 mins):Health News:1Heart Caregiver Services Director Randy Neil Clarito Brings Brain Fitness Education to Victoria Care Center Ventura 2Health News:1Heart Caregiver Services Director Randy Neil Clarito Brings Brain Fitness Education to Victoria Care Center Ventura 3Health News:1Heart Caregiver Services Director Randy Neil Clarito Brings Brain Fitness Education to Victoria Care Center Ventura 4Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 2Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 3Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 4Health News:Best ASP.NET Hosting Award for August 2014 Released By Top10BestSEOHosting.com 2Health News:Mexico vs. Bolivia Tickets at Dick’s Sporting Goods Park in Commerce City (Denver), CO: Ticket Down Slashes Ticket Prices on Mexico vs. Bolivia Exhibition Game 2Health News:Mexico vs. Bolivia Tickets at Dick’s Sporting Goods Park in Commerce City (Denver), CO: Ticket Down Slashes Ticket Prices on Mexico vs. Bolivia Exhibition Game 3Health News:NutriGold’s Organic Wholefood-Sourced Vitamin C Gets ConsumerLab’s Seal of Approval 2Health News:NutriGold’s Organic Wholefood-Sourced Vitamin C Gets ConsumerLab’s Seal of Approval 3
... and divorce can act as "weight shocks," leading people to add ... - according to a new study. But when it comes ... different for men than they are for women. For men, ... a divorce. But for women, the risk of a large weight ...
... businesses that sell alcohol in a community has been tied ... that the influence depends on the nature of the community. ... more disorganized communities are not so fortunate. Communities ... people living in poverty and in women-headed households with children ...
... probe developed by Massachusetts General Hospital (MGH) investigators may ... of the heart valves. In their Nature ... the team from the MGH Center for Systems Biology ... endocarditis in a mouse model was revealed by PET ...
... Researchers have discovered a key mechanism used by intestinal ... most common hospital-acquired bacterial infections a mechanism they ... protect against the effects of the antibiotic-resistant bacteria. ... to two powerful toxins generated by the bacteria ...
... -- Large numbers of less-educated white Americans are abandoning religion, ... attendance has declined among all white Americans, but the rate ... than twice that of college graduates, according to the researchers. ... the annual meeting of the American Sociological Association (ASA) in ...
... VEGAS Working moms have lower rates of depression than ... put working mothers at greater risk for depression, suggests new ... the American Sociological Association. The study shows that ... home lives can be blended with relative ease showed higher ...
Cached Medicine News:Health News:Large weight gains most likely for men after divorce, women after marriage 2Health News:Large weight gains most likely for men after divorce, women after marriage 3Health News:Study: Community organization can reduce, negate impact of alcohol outlets on neighborhood violence 2Health News:Imaging probe allows noninvasive detection of dangerous heart-valve infection 2Health News:New defense discovered against common hospital-acquired infection 2Health News:Many Less-Educated Whites Abandoning Religion 2Health News:Less depression for working moms who expect that they 'can't do it all' 2
(Date:8/29/2014)... DIEGO , Aug. 29, 2014   ... emerging biopharmaceutical company, announced today that Santosh Vetticaden, ... be leaving the Company, for personal reasons, in ... Chief Medical Officer of Aires Pharmaceuticals, which Mast ... former responsibilities as the Company,s interim Chief Medical ...
(Date:8/29/2014)... Research and Markets has announced the addition ... Pipeline Insight 2014" report to their offering. ... eradicate the prevalence of cancer have achieved limited success ... specificity, safety and large number of side effects, which ... It has been discovered that peptides can be used ...
(Date:8/29/2014)... SILVER SPRING, Md. , Aug. 29, 2014 /PRNewswire/ ... today that the U.S. District Court for the District ... in its favor in the company,s case against Sandoz, ... opinion, Judge Peter Sheridan ruled that U.S. ... Sandoz, Inc., and enjoined Sandoz from marketing its generic ...
Breaking Medicine Technology:Mast Therapeutics Announces Management Change 2Mast Therapeutics Announces Management Change 3Mast Therapeutics Announces Management Change 4Global Peptide Cancer Therapeutics Market & Pipeline Insight 2014 2District Court Decision Received In Remodulin Patent Case 2
... April 29 The recent announcement of the REDUCE trial ... brings optimism to the prostate cancer community as dutasteride (Avodart), ... to lower by 23 percent the risk of prostate cancer ... Health Network looks forward to this becoming an additional tool ...
... France, April 29 Stallergenes S.A.,announces the release of ... (VO 57.07) on a sublingual house dust mite desensitization ... pleased with the outcome of this study, which is ... house dust mites allergen in,treating perennial allergic rhinitis. Furthermore, ...
Cached Medicine Technology:Study Results Present Paradigm Shift; REDUCE Trial Shows New Hope for the Risk Reduction of Prostate Cancer 2Stallergenes S.A.: Positive Results From a Phase IIb/III Clinical Trial on the House Dust Mite Desensitization Tablet 2Stallergenes S.A.: Positive Results From a Phase IIb/III Clinical Trial on the House Dust Mite Desensitization Tablet 3Stallergenes S.A.: Positive Results From a Phase IIb/III Clinical Trial on the House Dust Mite Desensitization Tablet 4
The MICROsed-System is the ideal system back up support to be used as front-line instrument with small workloads....
... The ESR-100 is an automated 100-position ESR ... 50 samples daily. The instrument accurately and ... in 1.2ml or 2.0ml ESR-Vacuum Tubes. Results ... Westergren Method) and are available in 30 ...
The CA-500 series quickly and accurately measures up to 5 coagulation parameters. It is the analyzer of choice for low to mid volume laboratories, or as a backup to larger coagulation analyzers....
... Qwik-Let® Premier is our top-of-the-line ... the attributes of the Qwik-Let® ... patented Lan-X feature. The Lan-X ... and protection in the removal ...
Medicine Products: