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Loss Of Dystrophin: Common Thread In Cancer And MS Muscle Wasting

oteins were altered. The researchers then showed that cachexia is accelerated in mice that lack dystrophin and develop cancer. Furthermore, they showed that they could prevent cancer wasting in the mice by causing their muscle cells to over-produce dystrophin.

Last, the researchers tested muscle biopsies from 27 patients with gastrointestinal cancers for dystrophin and DGC. Eleven of the patients were confirmed cachectic, and ten of those showed dramatic reductions in dystrophin and significant loss of the DGC.

The authors conclude that the evidence strongly suggests that the wasting conditions in cancer and muscular dystrophy patients are similar, and that the loss of dystrophin and the DGC are important contributing factors in tumor-induced muscle wasting.
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TAG: Loss Dystrophin Common Thread Cancer And Muscle Wasting

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