Navigation Links
Loss Of Dystrophin: Common Thread In Cancer And MS Muscle Wasting

Recent research conducted at the Ohio State University shows that a wasting condition responsible for nearly a third of cancer deaths involves the loss of an essential muscle protein that is also lost in people with muscular // dystrophy.

The study findings, which appear in the November issue of the journal Cancer Cell, show that muscle cells lose significant amounts of the protein dystrophin during cancer wasting, and that subtle changes occur in two other proteins associated with dystrophin in the membrane of muscle cells. These proteins form the dystrophin glycoprotein complex. Dystrophin and DGC are also lost in Duchenne muscular dystrophy.

The loss of dystrophin and damage to the DGC appear to be key players in the development of both cancer wasting and muscular dystrophy.

Cancer wasting occurs most often in esophageal, stomach, colorectal, pancreatic, lung, and head and neck cancers. Cancer patients who develop wasting usually respond more poorly to therapy and have a shorter life span and lower quality of life.

The findings provide a better understanding of cancer wasting, also known as cancer cachexia, a condition first described more than 100 years ago that still lacks effective therapy. The findings also might lead to new ways to diagnose and treat the condition.

Cancer wasting occurs most often in esophageal, stomach, colorectal, pancreatic, lung, and head and neck cancers. The condition is induced by growth of the tumor, and it results in the loss of both fat and skeletal muscle mass. Cancer patients who develop wasting usually respond more poorly to therapy and have a shorter life span and lower quality of life.

Muscular dystrophy is a genetic disease that usually begins in childhood and results in the complete loss of dystrophin and the DGC from muscle.

The researchers found that dystrophin levels were reduced in the muscles of mice with cancer cachexia, and that two DGC pr
'"/>




Page: 1 2

Related medicine news :

1. Common contraception
2. Common Cold Remedy May Treat SARS
3. Common Plant Triggers Asthma
4. Pain Common in People with MS
5. Common Cold Found to Fight Cancer
6. Bullying – a Common Problem Among Childre
7. Common Medication Errors in Children
8. A Common Cause Of Allergy That Goes Unnoticed
9. Genetic Breakthrough in Common Eye Problem
10. Common Cold Found to Fight Cancer Cells
11. Side Effects Of Some Common Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Loss Dystrophin Common Thread Cancer And Muscle Wasting

(Date:7/29/2014)... July 29, 2014 A simplified anesthesia procedure may ... the cause of airway obstruction in patients with severe ... Analgesia . , Dr. Joshua H. Atkins and Dr. ... their colleagues have developed a new "ramp control" anesthetic ... show the "obstructive anatomy" responsible for sleep apnea. The ...
(Date:7/29/2014)... CRN International has promoted a longtime executive ... Upton, an 11-year veteran at the radio marketing company, ... managing the day-to-day execution of all CRN client campaigns. ... all activities for CRN clients, which include some ... The department interfaces directly with clients, sets project timelines ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 1WorldSync ... world’s leading healthcare suppliers will utilize the Global ... product information network to share product information with ... other trading partners across their global supply chain. ... ID at B. Braun: "B. Braun serves customers ...
(Date:7/29/2014)... July 29, 2014 The Affordable Care ... model of all hospitals. Studies show that over 400 ... simple, easy, low cost tool that great hospitals use ... 20 to 25%. , Their secret? Debriefing - the ... at the end of an operational event. Debriefing is ...
(Date:7/29/2014)... Kathleen Doheny HealthDay Reporter , ... low risk of cardiovascular disease may be able to take ... without harming their hearts, according to a new study. ... hormone replacement therapy had harmful effects on the heart. But, ... hormone treatments, and much further past menopause. In ...
Breaking Medicine News(10 mins):Health News:New anesthesia technique helps show cause of obstruction in sleep apnea 2Health News:New anesthesia technique helps show cause of obstruction in sleep apnea 3Health News:CRN International Names New Director to Lead Client Services Department 2Health News:B. Braun Selects 1WorldSync Unique Device Identification and Product Information Solution 2Health News:B. Braun Selects 1WorldSync Unique Device Identification and Product Information Solution 3Health News:One Brilliant Economic Survival Tool You Can Steal from the World's Best Hospitals 2Health News:One Brilliant Economic Survival Tool You Can Steal from the World's Best Hospitals 3Health News:Early Hormone Therapy May Be Safe for Women's Hearts 2Health News:Early Hormone Therapy May Be Safe for Women's Hearts 3
... the development of muscles.Da-Zhi Wang and other researchers of the ... the genes are among a recently discovered group of genes ... in the past few years have they been recognised as ... study authors said in an article that appeared in the ...
... experience with China, Pakistani pharmaceutical companies are keen to ... government // to relax the stringent visa norms. ... raw materials provided by the Chinese, apart from the ... problems with the Chinese, though their rates are cheaper ...
... Research Center has reported that maintaining the current recommended ... of cardiovascular disease. The researcher has asked the ... patients less than the recommended levels by aggressive blood ... is used to monitor the average amount of blood ...
... Baruch College has reported in his recent article that having ... . Dr. Brind has compiled data from recent studies of ... American Physicians and Surgeons. ,Professor Brind, ... that pregnancies leading to miscarriage or induced abortions does not ...
... obese people are in increased risk of developing eye ... Belkin and Zohar Habot-Wilner // , Goldschleger Eye Institute, ... and found that risk of developing eye problems are ... link between obesity and other chronic diseases and cancers. ...
... cholesterol can do to people. High-fat diets cause many patients' ... // to know what they consume. ,Now, new rules ... avoid trans fats, which plug arteries, and have been linked ... ,Trans fats are a result of manufacturers adding ...
Cached Medicine News:Health News:Pakistan drug companies seek trade ties with India 2Health News:Food labels to include information on trans fats in US 2Health News:Food labels to include information on trans fats in US 3
(Date:7/28/2014)... , July 28, 2014 STAAR Surgical Company ... and marketer of implantable lenses and delivery systems for ... quarter results and conference call with investors to July ... 2014.  The Company rescheduled the release date and conference ... services for Hideo Watanabe , President of STAAR ...
(Date:7/28/2014)... 2014 Reportbuyer.com has added a new market ... 2014-2018 https://www.reportbuyer.com/product/2225723/Global-Bone-Densitometers-Market-2014-2018.html ... a special type of X-ray test used to measure ... primarily to detect osteopenia or osteoporosis, diseases in which ... fractures is high. The purpose of bone densitometry is ...
(Date:7/28/2014)... -- June 28 th , 2014 – Oncolab, the ... cancer test, is making its AACC debut (booth #4051) at ... is a serum-based in vitro immunoassay, has been run for ... in the fight against cancer recurrence. Photo - ... million cancer survivors in the US alone, the race is ...
Breaking Medicine Technology:STAAR Surgical Moves Second Quarter Earnings Release and Conference Call One Day to July 31 2Global Bone Densitometers Market 2014-2018 2Global Bone Densitometers Market 2014-2018 3Global Bone Densitometers Market 2014-2018 4Global Bone Densitometers Market 2014-2018 5Oncolab, Inc. Exhibits Pioneering AMAS Cancer Test at AACC 2
... - Amgen,(Nasdaq:AMGN) today presented the results from a ... safety of Aranesp(R) (darbepoetin alfa) for the,treatment of ... or radiotherapy ("the 103 study"). Aranesp is not,approved ... these patients. These,results were presented in an oral ...
... therapeutic approach for the treatment,of early and metastatic ... - AEterna,Zentaris Inc. , a global, pure play ... presented an,abstract outlining in vivo data for its ... at the American,Association for Cancer Research (AACR) Annual ...
Cached Medicine Technology:Aranesp Phase 3 Study in Patients with Active Cancer Not Receiving,Concurrent Chemotherapy or Radiotherapy Presented at AACR Annual,Meeting 2Aranesp Phase 3 Study in Patients with Active Cancer Not Receiving,Concurrent Chemotherapy or Radiotherapy Presented at AACR Annual,Meeting 3Aranesp Phase 3 Study in Patients with Active Cancer Not Receiving,Concurrent Chemotherapy or Radiotherapy Presented at AACR Annual,Meeting 4Aranesp Phase 3 Study in Patients with Active Cancer Not Receiving,Concurrent Chemotherapy or Radiotherapy Presented at AACR Annual,Meeting 5Aranesp Phase 3 Study in Patients with Active Cancer Not Receiving,Concurrent Chemotherapy or Radiotherapy Presented at AACR Annual,Meeting 6Aranesp Phase 3 Study in Patients with Active Cancer Not Receiving,Concurrent Chemotherapy or Radiotherapy Presented at AACR Annual,Meeting 7AEterna Zentaris Discloses In Vivo Data for its GHRH Antagonist,JMR-132 at the AACR Annual Meeting in Los Angeles 2AEterna Zentaris Discloses In Vivo Data for its GHRH Antagonist,JMR-132 at the AACR Annual Meeting in Los Angeles 3
... The Leica MS2 is designed to perfectly ... as multidisciplinary use. The Leica MS2 combines ... M500 N with a innovative stand concept ... brakes, patented ABC balancing system for the ...
... loupes are quality surgical loupes featuring ... the healthcare professional a larger field ... field. Each set of SheerVision Loupes ... wooden box and includes side shields, ...
Surgical Loupes...
... The 1.5T Magnetom Sonata is a system ... research system and for cardiovascular and neuroradiological ... supported by previously stored optimized sequences, clinical ... is the fastest MR system in the ...
Medicine Products: