Navigation Links
Loss Of Dystrophin: Common Thread In Cancer And MS Muscle Wasting

Recent research conducted at the Ohio State University shows that a wasting condition responsible for nearly a third of cancer deaths involves the loss of an essential muscle protein that is also lost in people with muscular // dystrophy.

The study findings, which appear in the November issue of the journal Cancer Cell, show that muscle cells lose significant amounts of the protein dystrophin during cancer wasting, and that subtle changes occur in two other proteins associated with dystrophin in the membrane of muscle cells. These proteins form the dystrophin glycoprotein complex. Dystrophin and DGC are also lost in Duchenne muscular dystrophy.

The loss of dystrophin and damage to the DGC appear to be key players in the development of both cancer wasting and muscular dystrophy.

Cancer wasting occurs most often in esophageal, stomach, colorectal, pancreatic, lung, and head and neck cancers. Cancer patients who develop wasting usually respond more poorly to therapy and have a shorter life span and lower quality of life.

The findings provide a better understanding of cancer wasting, also known as cancer cachexia, a condition first described more than 100 years ago that still lacks effective therapy. The findings also might lead to new ways to diagnose and treat the condition.

Cancer wasting occurs most often in esophageal, stomach, colorectal, pancreatic, lung, and head and neck cancers. The condition is induced by growth of the tumor, and it results in the loss of both fat and skeletal muscle mass. Cancer patients who develop wasting usually respond more poorly to therapy and have a shorter life span and lower quality of life.

Muscular dystrophy is a genetic disease that usually begins in childhood and results in the complete loss of dystrophin and the DGC from muscle.

The researchers found that dystrophin levels were reduced in the muscles of mice with cancer cachexia, and that two DGC pr oteins were altered. The researchers then showed that cachexia is accelerated in mice that lack dystrophin and develop cancer. Furthermore, they showed that they could prevent cancer wasting in the mice by causing their muscle cells to over-produce dystrophin.

Last, the researchers tested muscle biopsies from 27 patients with gastrointestinal cancers for dystrophin and DGC. Eleven of the patients were confirmed cachectic, and ten of those showed dramatic reductions in dystrophin and significant loss of the DGC.

The authors conclude that the evidence strongly suggests that the wasting conditions in cancer and muscular dystrophy patients are similar, and that the loss of dystrophin and the DGC are important contributing factors in tumor-induced muscle wasting.
'"/>




Related medicine news :

1. Common contraception
2. Common Cold Remedy May Treat SARS
3. Common Plant Triggers Asthma
4. Pain Common in People with MS
5. Common Cold Found to Fight Cancer
6. Bullying – a Common Problem Among Childre
7. Common Medication Errors in Children
8. A Common Cause Of Allergy That Goes Unnoticed
9. Genetic Breakthrough in Common Eye Problem
10. Common Cold Found to Fight Cancer Cells
11. Side Effects Of Some Common Drugs
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/9/2016)... ... February 09, 2016 , ... A new study from ... and Medicare rates for a variety of medical services in Illinois as of ... the 2015 Fee Schedule Rates in Illinois, are professional medical services, hospital ...
(Date:2/9/2016)... (PRWEB) , ... February 09, ... ... print and e-book publishing software, in partnership with Snowfall4pod Digital, creators of ... a comprehensive book publishing, content management, global distribution and print-on-demand network. , ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... Establishment Labs, ... of Dr. David Hung to the company´s Board of Directors. , “We ... class scientist and an exceptional entrepreneur.” said Juan Jose Chacon Quiros, CEO of Establishment ...
(Date:2/9/2016)... ... February 10, 2016 , ... The Journal of Pain Research has ... field .” , As corresponding author Dr John F. Peppin says “Terminology matters, yet ... our chronic pain patients. ‘Chronic cancer pain’ and ‘chronic non-cancer pain’ are replete ...
(Date:2/9/2016)... (PRWEB) , ... February 09, 2016 , ... Dr. Rassouli, ... whitening packages. Teeth whitening is among the most popular cosmetic procedures in dentistry today, ... whitening needs. This can put them at risk of teeth whitening-related damage. For a ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)...  Sangamo BioSciences, Inc. (NASDAQ: SGMO ), ... its fourth quarter and full year 2015 financial ... therapeutic genome editing," said Edward Lanphier, Sangamo,s president ... (ZFN) technology leads the therapeutic genome editing field ... to move our ground-breaking genome editing programs through ...
(Date:2/9/2016)... Mast Therapeutics, Inc. (NYSE MKT: MSTX), ... disease and heart failure, today announced that it intends to ... stock in an underwritten public offering.  The offering is subject ... assurance as to whether or when the offering may be ... the offering.   --> --> ...
(Date:2/9/2016)... The global prefilled syringes market accounted for $3,905.1 million ... with a CAGR of 12.9% during 2015-2020. Among the ... global prefilled syringes market, with 90.1% share in 2014. ... global market of prefilled syringes is up surging with ... demand for vaccines, increasing prevalence of chronic and lifestyle ...
Breaking Medicine Technology: