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Longer-Lived Rodents Have Lower Levels of Thyroid Hormone

tudy determined the levels of T3 and T4 for each animal.

T4 levels vary the most

T4 levels varied significantly between all of the groups, with the shorter-lived groups having higher levels of T4 than longer-lived groups. The mice, for example, had twice as much T4 as the Damara mole-rats and had and three times more than that of the naked mole-rats, Pinto reported. There was also a significant difference in T3 levels between the naked mole-rats and the guinea pigs, but not between any of the other groups.

'These hormone concentration differences correlate with maximum species lifespan and suggest an important regulatory role of thyroid hormone in longevity,' the researchers concluded. However, because T3 levels did not differ significantly among all the groups, further research in this area using larger sample sizes (numbers of rodents in each group) is needed, Pinto said.

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